scholarly article | Q13442814 |
P2093 | author name string | Min Zhu | |
Robert S Weiss | |||
Rachel M Peters | |||
Houchun Liu | |||
Stephanie A Yazinski | |||
Amy Cassano | |||
Joshua Darfler | |||
Peter S Levitt | |||
P2860 | cites work | Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint | Q24292703 |
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery | Q24301431 | ||
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair | Q24338781 | ||
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint | Q24604730 | ||
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin | Q24672721 | ||
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines | Q24683034 | ||
The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae | Q27931291 | ||
Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage | Q28138254 | ||
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice | Q28143813 | ||
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome | Q28183834 | ||
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress | Q28201846 | ||
Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer | Q36843803 | ||
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. | Q37695856 | ||
Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1. | Q39086313 | ||
Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects | Q40547899 | ||
Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling | Q40653014 | ||
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality | Q41283109 | ||
Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair | Q41813386 | ||
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling | Q41888313 | ||
Forward genetic screens for meiotic and mitotic recombination-defective mutants in mice | Q44760564 | ||
Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe | Q45144500 | ||
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice | Q47315084 | ||
Fragile sites: breaking up over a slowdown | Q48025473 | ||
Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex. | Q53620807 | ||
The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. | Q53654201 | ||
Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. | Q53989253 | ||
Telomere and Telomerase Modulation by the Mammalian Rad9/Rad1/Hus1 DNA-Damage-Checkpoint Complex | Q61872127 | ||
Effects of genetic background on tumorigenesis in p53-deficient mice | Q71711400 | ||
Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability | Q74478491 | ||
ATM and ATR check in on origins: a dynamic model for origin selection and activation | Q81284851 | ||
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage | Q28266407 | ||
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background | Q28274709 | ||
Cell-cycle checkpoints and cancer | Q28293996 | ||
The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining | Q28505397 | ||
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice | Q28507011 | ||
Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation | Q28509716 | ||
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice | Q28509807 | ||
Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene | Q28511537 | ||
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway | Q28513656 | ||
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm | Q28586941 | ||
ATR disruption leads to chromosomal fragmentation and early embryonic lethality | Q28591433 | ||
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination | Q28594895 | ||
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours | Q29547697 | ||
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Q29614216 | ||
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Q29614217 | ||
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination | Q29615355 | ||
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA | Q29615386 | ||
Tumor spectrum analysis in p53-mutant mice | Q29617436 | ||
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts | Q29618748 | ||
Regulation of DNA replication by ATR: signaling in response to DNA intermediates | Q31101647 | ||
Classification and relationships of induced chromosomal structual changes | Q33586865 | ||
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes | Q33617643 | ||
Genetic instability and darwinian selection in tumours | Q33804007 | ||
Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin | Q34121003 | ||
A murine model of Nijmegen breakage syndrome | Q34124812 | ||
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event | Q34149326 | ||
Conditional alleles in mice: practical considerations for tissue-specific knockouts | Q34540094 | ||
The DNA damage response during DNA replication | Q34561760 | ||
The Fanconi road to cancer | Q35189910 | ||
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress | Q35199909 | ||
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair | Q35618148 | ||
Mechanisms of cellular senescence in human and mouse cells. | Q35770883 | ||
An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome | Q35848567 | ||
Checkpoint activation regulates mutagenic translesion synthesis | Q35963618 | ||
Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair | Q36159147 | ||
Micronuclei as an index of cytogenetic damage: Past, present, and future | Q36811598 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 2189-2201 | |
P577 | publication date | 2007-01-12 | |
P1433 | published in | Molecular and Cellular Biology | Q3319478 |
P1476 | title | Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. | |
P478 | volume | 27 |
Q90258518 | A tough row to hoe: when replication forks encounter DNA damage |
Q58090480 | Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania |
Q27324367 | Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance |
Q38981181 | Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses |
Q24313157 | Crystal structure of the human rad9-hus1-rad1 clamp |
Q36083139 | Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1 |
Q37482118 | Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration |
Q37317128 | Gadd45b deficiency promotes premature senescence and skin aging |
Q48195510 | HUS1 regulates in vivo responses to genotoxic chemotherapies |
Q33880788 | Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling |
Q27340183 | Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis |
Q22001505 | Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma |
Q37605353 | Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress |
Q36922875 | Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses. |
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