Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.

scientific article published on 12 January 2007

Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01763-06
P932PMC publication ID1820507
P698PubMed publication ID17220276

P2093author name stringMin Zhu
Robert S Weiss
Rachel M Peters
Houchun Liu
Stephanie A Yazinski
Amy Cassano
Joshua Darfler
Peter S Levitt
P2860cites workCritical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpointQ24292703
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machineryQ24301431
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repairQ24338781
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpointQ24604730
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinQ24672721
Quantitative studies of the growth of mouse embryo cells in culture and their development into established linesQ24683034
The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiaeQ27931291
Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damageQ28138254
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in miceQ28143813
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndromeQ28183834
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressQ28201846
Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometerQ36843803
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.Q37695856
Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1.Q39086313
Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defectsQ40547899
Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint SignalingQ40653014
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethalityQ41283109
Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repairQ41813386
Unwind and slow down: checkpoint activation by helicase and polymerase uncouplingQ41888313
Forward genetic screens for meiotic and mitotic recombination-defective mutants in miceQ44760564
Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombeQ45144500
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in miceQ47315084
Fragile sites: breaking up over a slowdownQ48025473
Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.Q53620807
The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.Q53654201
Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.Q53989253
Telomere and Telomerase Modulation by the Mammalian Rad9/Rad1/Hus1 DNA-Damage-Checkpoint ComplexQ61872127
Effects of genetic background on tumorigenesis in p53-deficient miceQ71711400
Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instabilityQ74478491
ATM and ATR check in on origins: a dynamic model for origin selection and activationQ81284851
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damageQ28266407
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient backgroundQ28274709
Cell-cycle checkpoints and cancerQ28293996
The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joiningQ28505397
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) miceQ28507011
Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiationQ28509716
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) miceQ28509807
Conditional inactivation of the mouse Hus1 cell cycle checkpoint geneQ28511537
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathwayQ28513656
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with AtmQ28586941
ATR disruption leads to chromosomal fragmentation and early embryonic lethalityQ28591433
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombinationQ28594895
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsQ29614216
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisQ29614217
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombinationQ29615355
Telomere shortening and tumor formation by mouse cells lacking telomerase RNAQ29615386
Tumor spectrum analysis in p53-mutant miceQ29617436
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblastsQ29618748
Regulation of DNA replication by ATR: signaling in response to DNA intermediatesQ31101647
Classification and relationships of induced chromosomal structual changesQ33586865
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexesQ33617643
Genetic instability and darwinian selection in tumoursQ33804007
Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatinQ34121003
A murine model of Nijmegen breakage syndromeQ34124812
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling eventQ34149326
Conditional alleles in mice: practical considerations for tissue-specific knockoutsQ34540094
The DNA damage response during DNA replicationQ34561760
The Fanconi road to cancerQ35189910
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stressQ35199909
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repairQ35618148
Mechanisms of cellular senescence in human and mouse cells.Q35770883
An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndromeQ35848567
Checkpoint activation regulates mutagenic translesion synthesisQ35963618
Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repairQ36159147
Micronuclei as an index of cytogenetic damage: Past, present, and futureQ36811598
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)2189-2201
P577publication date2007-01-12
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleGenome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.
P478volume27

Reverse relations

cites work (P2860)
Q90258518A tough row to hoe: when replication forks encounter DNA damage
Q58090480Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania
Q27324367Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance
Q38981181Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses
Q24313157Crystal structure of the human rad9-hus1-rad1 clamp
Q36083139Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1
Q37482118Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration
Q37317128Gadd45b deficiency promotes premature senescence and skin aging
Q48195510HUS1 regulates in vivo responses to genotoxic chemotherapies
Q33880788Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling
Q27340183Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis
Q22001505Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma
Q37605353Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress
Q36922875Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.

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