Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1. (scientific article published on November 2006)

Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6

Q24292187

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

Q24301197

The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery

Q24301431

Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells

Q24302320

The mismatch repair system is required for S-phase checkpoint activation

Q24321503

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

Q24550745

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

Q24606873

Replication-associated repair of adenine:8-oxoguanine mispairs by MYH.

Q40748374

Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair

Q41813386

Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

Q41834311

Direct interaction of proliferating cell nuclear antigen with the p125 catalytic subunit of mammalian DNA polymerase delta

Q42058088

Fission yeast (Schizosaccharomyces pombe) cells defective in the MutY-homologous glycosylase activity have a mutator phenotype and are sensitive to hydrogen peroxide

Q43781898

Functional interaction of MutY homolog with proliferating cell nuclear antigen in fission yeast, Schizosaccharomyces pombe

Q43862921

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

Q43871566

Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain

Q43955889

Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe

Q45144500

Predicting intrinsic disorder from amino acid sequence

Q47422786

Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.

Q53620807

The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.

Q53654201

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

Q54710915

Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process

Q24644844

Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis

Q24801922

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

Q24806674

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Q25938984

Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

Q27643123

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

Q27733704

Protein secondary structure prediction based on position-specific scoring matrices

Q27860483

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Q27860503

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Q27860662

The DNA damage response: putting checkpoints in perspective

Q28131713

Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair

Q28138546

Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression

Q28142735

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

Q28212369

Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1

Q28214307

PCNA binding through a conserved motif

Q28274063

hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs

Q28343394

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

Q28610376

Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch

Q28645615

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

Q29615251

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

Q29616532

Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint

Q31036173

Characterization of the recombinant MutY homolog, an adenine DNA glycosylase, from yeast Schizosaccharomyces pombe

Q32021272

Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC.

Q32184097

Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes

Q33617643

Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein

Q33636195

Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondria

Q33786679

Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria

Q33939207

The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair

Q35618148

The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks

Q35893379

Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G.C-->T.A transversions in simian kidney cells

Q36091215

Evidence that DNA damage detection machinery participates in DNA repair

Q36117978

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

Q36647845

The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.

Q37695856

Repair of A/G and A/8-oxoG mismatches by MutY adenine DNA glycosylase

Q38309044

P433

issue

P407

language of work or name

English

Q1860

P1104

number of pages

P304

page(s)

53-62

P577

publication date

2006-11-01

P1433

published in

Biochemical Journal

Q864221

P1476

title

Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1.

P478

volume

400

Reverse relations

cites work (P2860)

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Q50991068	A role for Myh1 in DNA repair after treatment with strand-breaking and crosslinking chemotherapeutic agents
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Q35676284	Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.
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Q35615685	Increased sensitivity of DNA damage response-deficient cells to stimulated microgravity-induced DNA lesions
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Q37669033	Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast
Q42425324	Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding.
Q37267542	Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex
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Q39251921	Loss of MUTYH function in human cells leads to accumulation of oxidative damage and genetic instability.
Q21131242	MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA
Q26998490	MUTYH the base excision repair gene family member associated with colorectal cancer polyposis
Q35704467	Mammalian MutY homolog (MYH or MUTYH) protects cells from oxidative DNA damage
Q35614009	Need telomere maintenance? Call 911
Q36972154	Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
Q34306735	Recent advances in the structural mechanisms of DNA glycosylases
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Q35660532	SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp
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Q27656003	Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint Complex
Q36952958	Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1
Q33953047	Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
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