Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

scientific article published on 24 October 2013

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DNAREP.2013.09.007
P932PMC publication ID3857741
P698PubMed publication ID24209961

P50authorAlexander C DrohatQ47503014
P2093author name stringWuyuan Lu
Jin Jin
Weirong Yuan
Brittney A Manvilla
Eric A Toth
A-Lien Lu
Bor-Jang Hwang
Randall Gunther
Shuja S Malik
Dimeka N Patterson
Paz J Luncsford
Leonora J Lipinski
Snigdha Kalvakolanu
P2860cites workTwo divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanismQ24291085
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machineryQ24301431
Crystal structure of the human rad9-hus1-rad1 clampQ24313157
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNAQ24319977
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.Q24329154
Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1Q24543007
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]Q27621279
Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulationQ27655485
Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint ComplexQ27656003
Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylaseQ27657850
A Structural Hinge in Eukaryotic MutY Homologues Mediates Catalytic Activity and Rad9–Rad1–Hus1 Checkpoint Complex InteractionsQ27664268
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamilyQ27766319
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repairQ28138546
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repairQ28198657
PCNA binding through a conserved motifQ28274063
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathwayQ28513656
Quality control by DNA repairQ28608962
Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatchQ28645615
Base-excision repair of oxidative DNA damageQ29615373
Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturantsQ29617228
Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associationsQ29620211
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsQ30420636
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.Q30497640
Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?Q33558839
Oxidative DNA damage, antioxidants, and cancerQ33638707
DNA repair mechanisms for the recognition and removal of damaged DNA bases.Q33689923
Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondriaQ33786679
Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1.Q33823467
Synthesis and characterization of human alpha-defensins 4-6.Q34341953
Substrate channeling in mammalian base excision repair pathways: passing the batonQ34412541
Abasic site binding by the human apurinic endonuclease, Ape, and determination of the DNA contact sitesQ34626537
Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNAQ34723697
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repairQ35618148
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repairQ35829262
The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylaseQ35829284
Protein-protein interactions and posttranslational modifications in mammalian base excision repairQ36088615
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modificationQ36751371
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.Q37695856
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.Q38293786
Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonucleaseQ38307342
Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and G365D murine MYH.Q38331638
A dimeric mechanism for contextual target recognition by MutY glycosylase.Q38360740
Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1.Q39086313
NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.Q39468302
Repair activities of human 8-oxoguanine DNA glycosylase are stimulated by the interaction with human checkpoint sensor Rad9-Rad1-Hus1 complexQ39823769
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.Q40725491
Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complexQ41952309
Direct interaction of proliferating cell nuclear antigen with the p125 catalytic subunit of mammalian DNA polymerase deltaQ42058088
Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stabilityQ42161686
Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylaseQ42190776
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sitesQ42631836
Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumorsQ43871566
An Escherichia coli MutY mutant without the six-helix barrel domain is a dimer in solution and assembles cooperatively into multisubunit complexes with DNA.Q45084855
Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonucleaseQ45267030
Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.Q53620807
The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.Q53654201
Proliferating Cell Nuclear Antigen Facilitates Excision in Long-patch Base Excision RepairQ57706957
Passing the baton in base excision repairQ73505096
Defining folding and unfolding reactions of apocytochrome b5 using equilibrium and kinetic fluorescence measurementsQ78021456
P433issue12
P304page(s)1043-1052
P577publication date2013-10-24
P1433published inDNA RepairQ3894086
P1476titleCoordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions
P478volume12

Reverse relations

cites work (P2860)
Q33926437AP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site Product
Q52571273Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature.
Q39136548Base excision repair of oxidative DNA damage: from mechanism to disease.
Q37669033Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast
Q38238405Regulation of base excision repair proteins by ubiquitylation.
Q39087831Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine
Q35660532SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp
Q89453864The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites
Q49988732Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.

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