scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0960-9822(01)00626-1 |
P698 | PubMed publication ID | 11790307 |
P50 | author | Shuhei Matsuoka | Q29839153 |
P2093 | author name string | Philip Leder | |
Robert S. Weiss | |||
Stephen J. Elledge | |||
P2860 | cites work | Linkage of ATM to cell cycle regulation by the Chk2 protein kinase | Q22008502 |
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase | Q22008669 | ||
A role for ATR in the DNA damage-induced phosphorylation of p53 | Q22008733 | ||
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 | Q24311891 | ||
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 | Q24550952 | ||
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress | Q24597483 | ||
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe | Q24607761 | ||
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage | Q24651421 | ||
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro | Q24656275 | ||
Surfing the p53 network | Q28032484 | ||
The DNA damage response: putting checkpoints in perspective | Q28131713 | ||
The G2-phase DNA-damage checkpoint | Q28138479 | ||
Substrate specificities and identification of putative substrates of ATM kinase family members | Q28141080 | ||
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway | Q28141324 | ||
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice | Q28143813 | ||
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses | Q28202998 | ||
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 | Q28247761 | ||
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes | Q33617643 | ||
A conserved role for the Hus1 checkpoint protein in eukaryotic genome maintenance | Q35132624 | ||
Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? | Q41513765 | ||
Protein-PCNA interactions: a DNA-scanning mechanism? | Q47714565 | ||
A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins | Q63383723 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Transformation related protein 53 | Q14818136 |
Checkpoint kinase 1 | Q21495077 | ||
HUS1 checkpoint clamp component | Q21496481 | ||
P304 | page(s) | 73–77 | |
P577 | publication date | 2002-01-08 | |
P1433 | published in | Current Biology | Q1144851 |
P1476 | title | Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway | |
P478 | volume | 12 |
Q39142830 | A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function |
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Q38472371 | Chromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme |
Q37379745 | Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions. |
Q24292703 | Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint |
Q41352911 | Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model |
Q36325437 | DNA damage checkpoints in mammals |
Q35814896 | Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression |
Q42454455 | Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains |
Q36083139 | Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1 |
Q40547899 | Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects |
Q33319284 | Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint |
Q37482118 | Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration |
Q33301901 | EMT tumorigenesis in the mouse mammary gland |
Q35944680 | Early events in the DNA damage response |
Q36696093 | Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant |
Q36573959 | Genetic instability in cancer cells by impaired cell cycle checkpoints |
Q28636919 | Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions |
Q35676284 | Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. |
Q26851196 | Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells |
Q34149326 | Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event |
Q48195510 | HUS1 regulates in vivo responses to genotoxic chemotherapies |
Q27325197 | Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks |
Q28206333 | Human claspin is required for replication checkpoint control |
Q34072906 | Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response |
Q35650781 | Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells |
Q36891684 | Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts |
Q28509716 | Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation |
Q37198572 | Living on a break: cellular senescence as a DNA-damage response |
Q37019406 | Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins |
Q33210398 | Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway |
Q33815487 | Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA. |
Q40653014 | Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling |
Q44779418 | Rad9 protects cells from topoisomerase poison-induced cell death |
Q33832728 | Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition |
Q28506717 | Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345 |
Q37605353 | Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress |
Q35856701 | Specific role of Chk1 phosphorylations in cell survival and checkpoint activation |
Q28505397 | The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining |
Q35205026 | The fork and the kinase: a DNA replication tale from a CHK1 perspective |
Q24682656 | The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase |
Q38256335 | Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease |