Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

scientific journal article

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(01)00626-1
P698PubMed publication ID11790307

P50authorShuhei MatsuokaQ29839153
P2093author name stringPhilip Leder
Robert S. Weiss
Stephen J. Elledge
P2860cites workLinkage of ATM to cell cycle regulation by the Chk2 protein kinaseQ22008502
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphataseQ22008669
A role for ATR in the DNA damage-induced phosphorylation of p53Q22008733
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53Q24311891
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Q24550952
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressQ24597483
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombeQ24607761
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damageQ24651421
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitroQ24656275
Surfing the p53 networkQ28032484
The DNA damage response: putting checkpoints in perspectiveQ28131713
The G2-phase DNA-damage checkpointQ28138479
Substrate specificities and identification of putative substrates of ATM kinase family membersQ28141080
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathwayQ28141324
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in miceQ28143813
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesQ28202998
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25Q28247761
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexesQ33617643
A conserved role for the Hus1 checkpoint protein in eukaryotic genome maintenanceQ35132624
Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?Q41513765
Protein-PCNA interactions: a DNA-scanning mechanism?Q47714565
A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteinsQ63383723
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectTransformation related protein 53Q14818136
Checkpoint kinase 1Q21495077
HUS1 checkpoint clamp componentQ21496481
P304page(s)73–77
P577publication date2002-01-08
P1433published inCurrent BiologyQ1144851
P1476titleHus1 acts upstream of chk1 in a mammalian DNA damage response pathway
P478volume12

Reverse relations

cites work (P2860)
Q39142830A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function
Q28506572AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline
Q29547735ATM and related protein kinases: safeguarding genome integrity
Q98161266ATR Signaling in Mammalian Meiosis: From Upstream Scaffolds to Downstream Signaling
Q30444319ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication
Q33227756Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo
Q46446307Alterations of Chk1 and Chk2 expression in colon cancer.
Q47069226Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis
Q33963387Cell-cycle responses to DNA damage in G2.
Q35006441Checking on the fork: the DNA-replication stress-response pathway
Q29617706Chk1 and Chk2 kinases in checkpoint control and cancer
Q38472371Chromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme
Q37379745Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.
Q24292703Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint
Q41352911Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model
Q36325437DNA damage checkpoints in mammals
Q35814896Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression
Q42454455Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
Q36083139Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1
Q40547899Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects
Q33319284Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint
Q37482118Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration
Q33301901EMT tumorigenesis in the mouse mammary gland
Q35944680Early events in the DNA damage response
Q36696093Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant
Q36573959Genetic instability in cancer cells by impaired cell cycle checkpoints
Q28636919Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions
Q35676284Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.
Q26851196Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells
Q34149326Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event
Q48195510HUS1 regulates in vivo responses to genotoxic chemotherapies
Q27325197Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks
Q28206333Human claspin is required for replication checkpoint control
Q34072906Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response
Q35650781Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells
Q36891684Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts
Q28509716Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation
Q37198572Living on a break: cellular senescence as a DNA-damage response
Q37019406Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins
Q33210398Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway
Q33815487Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.
Q40653014Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling
Q44779418Rad9 protects cells from topoisomerase poison-induced cell death
Q33832728Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition
Q28506717Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345
Q37605353Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress
Q35856701Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
Q28505397The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining
Q35205026The fork and the kinase: a DNA replication tale from a CHK1 perspective
Q24682656The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase
Q38256335Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease