Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation

scientific journal article

Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1093/NAR/GKH243
P8608Fatcat IDrelease_a3cft5tkcbbozpjqimkinuyq2m
P932PMC publication ID373359
P698PubMed publication ID14762204
P5875ResearchGate publication ID8887253

P2093author name stringXiang Wang
Ya Wang
Jun Guan
Baocheng Hu
George Iliakis
Robert S. Weiss
P2860cites workHuman homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complexQ22008596
The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1Q22009947
The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9Q22254566
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesisQ24291114
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointQ24292395
Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpointQ24292703
Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9Q24297471
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpointsQ24538300
S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase functionQ40769630
Prolonged inhibition by X-rays of DNA synthesis in cells obtained by transformation of primary rat embryo fibroblasts with oncogenes H-ras and v-mycQ41142012
Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damageQ41232936
When checkpoints failQ41352428
Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sitesQ41526470
Persistent inhibition of DNA synthesis after radiation exposure in four clones obtained from rat embryo fibroblasts by transfection with the oncogenes H-ras plus v-mycQ41539550
Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication blockQ44194191
Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1.Q44388713
Radiation effects on DNA chain growth in mammalian cells.Q53839635
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damageQ54162557
Fission yeast genes involved in coupling mitosis to completion of DNA replicationQ63383735
The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeastQ64388851
Persistent inhibition of DNA synthesis in irradiated rat embryo fibroblasts expressing the oncogenes H-ras plus v-myc derives from inhibition of replicon initiation and is mitigated by staurosporineQ70586627
Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?Q73306178
Conserved domains in DNA repair proteins and evolution of repair systemsQ24548678
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damageQ24672492
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenanceQ24672646
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinQ24672721
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
The DNA replication fork in eukaryotic cells.Q27939216
The DNA damage response: putting checkpoints in perspectiveQ28131713
The G2-phase DNA-damage checkpointQ28138479
PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibitionQ28143834
Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complexQ28187599
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressQ28201846
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesQ28202998
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
An ATM-independent S-phase checkpoint response involves CHK1 pathwayQ28209816
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathwayQ28513656
CHK1-regulated S-phase checkpoint response reduces camptothecin cytotoxicityQ28571439
Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylationQ30309867
Intranuclear co-location of newly replicated DNA and PCNA by simultaneous immunofluorescent labelling and confocal microscopy in MCF-7 cellsQ31164025
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiationQ33558779
ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activationQ33940379
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling eventQ34149326
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agentsQ34188494
A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Q34191111
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damageQ34443534
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stressQ35199909
Checkpoint activation regulates mutagenic translesion synthesisQ35963618
Radiosensitivity in ataxia-telangiectasia: a new explanationQ36419108
DNA damage enhances melanogenesisQ37730186
Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment.Q38289758
Formation of nascent DNA molecules during inhibition of replicon initiation in mammalian cellsQ38526532
X-Ray-Induced Inhibition of DNA Synthesis in Chinese Hamster Ovary, Human HeLa, and Mouse L CellsQ38526629
Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9Q39450987
The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replicationQ39542617
Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.Q40482010
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathwaysQ40750310
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)767–775
P577publication date2004-01-01
P1433published inNucleic Acids ResearchQ135122
P1476titleInvolvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation
P478volume32

Reverse relations

cites work (P2860)
Q40397969Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis
Q53599798Checkpoint regulation of replication dynamics in UV-irradiated human cells.
Q37357566Checkpoint regulation of replication forks: global or local?
Q38472371Chromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme
Q27324367Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance
Q28511537Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene
Q43116506DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts
Q36556389Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines
Q42054523Functional interactions of DNA topoisomerases with a human replication origin
Q35676284Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.
Q46606543Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes
Q35650781Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells
Q36891684Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts
Q41867379PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.
Q38625638Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA.
Q93363776Role of N-acetyl cysteine and acetyl-l-carnitine combination treatment on DNA-damage-related genes induced by radiation in HEI-OC1 cells
Q36922875Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.
Q33232869The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway
Q28505397The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining
Q24683336The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement
Q37606136The human intra-S checkpoint response to UVC-induced DNA damage
Q35950241The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses
Q28306393The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons
Q35630642WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes
Q33914584cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA.

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