Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage

scientific article published on February 1996

Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(02)00452-9
P698PubMed publication ID8673466
P5875ResearchGate publication ID14527209

P2093author name stringLi R
Beach D
Stillman B
Hannon GJ
P2860cites workThe p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblastsQ24336806
WAF1, a potential mediator of p53 tumor suppressionQ27861121
DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiaeQ27937651
The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiaeQ27939221
Proliferating cell nuclear antigen is required for DNA excision repairQ28182009
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformationQ28249159
p21 is a universal inhibitor of cyclin kinasesQ28257305
Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary proteinQ28282869
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigenQ28303106
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint controlQ29616465
Cell cycle control and cancerQ29617536
Radiation-induced cell cycle arrest compromised by p21 deficiencyQ29620237
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanismQ34235866
Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycleQ34296821
Purification of PCNA as a nucleotide excision repair proteinQ35069851
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzymeQ35739744
A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repairQ36553838
Mammalian DNA nucleotide excision repair reconstituted with purified protein components.Q36697936
Mechanisms of DNA excision repairQ40556396
Transcription-coupled repair and human diseaseQ40556402
Nucleotide excision repair. II: From yeast to mammalsQ40828389
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.Q41358760
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cellsQ41368682
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.Q41368691
Reconstitution of human DNA repair excision nuclease in a highly defined systemQ41370395
Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repairQ41423739
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.Q41436520
p21-containing cyclin kinases exist in both active and inactive statesQ41451975
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.Q41454927
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.Q41508377
Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?Q41513765
Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sitesQ41526470
Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesisQ41562146
Two types of proliferating cell nuclear antigen (PCNA) complex formation in quiescent normal and xeroderma pigmentosum group A fibroblasts following ultraviolet light (uv) irradiationQ42087151
Increased nuclear cyclin/PCNA antigen staining of non S-phase transformed human amnion cells engaged in nucleotide excision DNA repairQ44606713
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.Q45993768
Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycleQ46632255
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative stateQ47919827
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1Q59063779
Redistribution of U-snRNPs during mitosisQ69985836
Evidence for a p53‐independent pathway for upregulation of SDI1/CIP1/WAF1/P21 RNA in human cellsQ71647788
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damageQ72297293
Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinasesQ72531722
Ordering S phase and M phase in the cell cycleQ72790820
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)189-199
P577publication date1996-02-01
P1433published inCurrent BiologyQ1144851
P1476titleSubcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage
P478volume6

Reverse relations

cites work (P2860)
Q47761479A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells
Q73692291A novel, nerve growth factor-activated pathway involving nitric oxide, p53, and p21WAF1 regulates neuronal differentiation of PC12 cells
Q28385780A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle
Q24555149A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen
Q35094511Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis
Q64069395Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability
Q36422719Absence of deletions but frequent loss of expression of p16INK4 in human ovarian tumours
Q36522379Activity and nature of p21(WAF1) complexes during the cell cycle
Q53358254An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosis.
Q90194905Antimicrobial Photodynamic Therapy in Combination with Nystatin in the Treatment of Experimental Oral Candidiasis Induced by Candida albicans Resistant to Fluconazole
Q37185312Assembly, activation, and substrate specificity of cyclin D1/Cdk2 complexes
Q34266465Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo
Q47827995Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis.
Q39220493Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells.
Q33884776Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
Q33774973Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex
Q28139755Detection of chromatin-bound PCNA in mammalian cells and its use to study DNA excision repair
Q29619360Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Q46075899Dynamic forces in the cell cycle affecting fibroblasts in pressure ulcers
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Q28628590Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair
Q34963960Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice
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Q77845951Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
Q24310880Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
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Q28143638Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres
Q34742793Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
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Q39499342Inhibitory effects of antagonists of growth hormone releasing hormone on experimental prostate cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins.
Q40106128Interaction of estrogen receptor alpha with proliferating cell nuclear antigen
Q28509716Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation
Q39927746Local action of the chromatin assembly factor CAF-1 at sites of nucleotide excision repair in vivo
Q61815012Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40
Q40939839Muscarinic cholinergic receptors activate both inhibitory and stimulatory growth mechanisms in NIH3T3 cells
Q41094353Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor
Q24320001Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase
Q53431329Oligosaccharides from human milk induce growth arrest via G2/M by influencing growth-related cell cycle genes in intestinal epithelial cells.
Q35033462P21Waf1 control of epithelial cell cycle and cell fate
Q24548219PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain
Q28274063PCNA binding through a conserved motif
Q33724384Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity
Q30434263Phosphorylation regulates Id3 function in vascular smooth muscle cells
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Q30397641Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation
Q46409564Proneness to UV-induced apoptosis in human fibroblasts defective in transcription coupled repair is associated with the lack of Mdm2 transactivation
Q48670711Protein kinase B/Akt may regulate G2/M transition in the fertilized mouse egg by changing the localization of p21(Cip1/WAF1).
Q33601097Radiation inducible DNA repair processes in eukaryotes
Q27324389Real-time imaging of DNA damage in yeast cells using ultra-short near-infrared pulsed laser irradiation
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Q30827745Reduced extractability of the XPA DNA repair protein in ultraviolet light-irradiated mammalian cells
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Q40243606Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation
Q42055057Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
Q40301471Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen
Q41030164Staurosporine-sensitive protein phosphorylation is required for postreplication DNA repair in human cells.
Q40765889Stimulation of C32 and G361 melanoma cells using oleoyl acetyl glycerol and its effect on sulphur mustard cytotoxicity
Q27733704Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA
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Q36889863The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo
Q36707756The baculoviruses occlusion-derived virus: virion structure and function
Q35646698The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light
Q34176430Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators
Q40280118Varicella-zoster virus infection of human foreskin fibroblast cells results in atypical cyclin expression and cyclin-dependent kinase activity
Q40810986p21(waf1/cip1)-null human fibroblasts are deficient in nucleotide excision repair downstream the recruitment of PCNA to DNA repair sites
Q37911434p21Cip1/Waf1 protein and its function based on a subcellular localization [corrected].
Q36042648p53-mediated protective responses to UV irradiation.

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