Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway

scientific article published on 01 May 1999

Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1040183970
P356DOI10.1038/SJ.ONC.1202681
P698PubMed publication ID10359535

P2093author name stringFitzgerald P
Fotedar A
Fotedar R
Rousseau D
Boulaire J
Cannella D
P2860cites workCloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsQ24314293
Structural basis of cyclin-dependent kinase activation by phosphorylationQ24315902
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
The retinoblastoma protein and cell cycle controlQ27860722
Nuclear targeting sequences--a consensus?Q27860997
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Proliferating cell nuclear antigen is required for DNA excision repairQ28182009
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformationQ28249159
p21 is a universal inhibitor of cyclin kinasesQ28257305
Inhibition of cell proliferation by p107, a relative of the retinoblastoma proteinQ28260016
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distributionQ28300442
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor geneQ28300451
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystinQ28300614
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigenQ28303106
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Nucleocytoplasmic transport: signals, mechanisms and regulationQ29547904
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domainQ29614381
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
Inhibition of cyclin-dependent kinases by p21Q34447738
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzymeQ35739744
Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma proteinQ36560262
Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiationQ36564865
WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinasesQ36570903
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathwayQ36648425
Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA.Q36699598
p21 Disrupts the interaction between cdk2 and the E2F-p130 complexQ40018242
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppressionQ40018354
Analysis of wild-type and mutant p21WAF-1 gene activitiesQ40018618
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitorsQ40020347
Activation-induced T-cell death is cell cycle dependent and regulated by cyclin B.Q40021594
Cyclins, Cdks, and cyclin kinase inhibitors.Q40431200
Cdk inhibitors: on the threshold of checkpoints and developmentQ40606649
Smart machines at the DNA replication fork.Q40704705
Targets of cyclin-dependent protein kinases.Q40914611
Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damageQ41232936
p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.Q41325340
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.Q41358760
Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repairQ41423739
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.Q41436520
Cyclin a is required for the onset of DNA replication in mammalian fibroblastsQ44752373
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extractsQ46207798
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1Q59063779
Association of p34cdc with Replicating DNAQ68281280
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsinsQ70250641
The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibitionQ71891816
Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1Q71985306
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21Q72036862
p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cellsQ74190453
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)3290-3302
P577publication date1999-05-01
P1433published inOncogeneQ1568657
P1476titleGrowth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
P478volume18

Reverse relations

cites work (P2860)
Q40705725Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21(WAF1) down-regulation -- effect of transforming growth factor beta.
Q37461249MAP kinase dependent cyclinE/cdk2 activity promotes DNA replication in early sea urchin embryos
Q28205253Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation
Q33908311Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
Q42055057Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
Q34076012Strategies for manipulating the p53 pathway in the treatment of human cancer.

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