Analysis of wild-type and mutant p21WAF-1 gene activities

scientific article published on April 1996

Analysis of wild-type and mutant p21WAF-1 gene activities is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.16.4.1786
P932PMC publication ID231165
P698PubMed publication ID8657154

P2093author name stringX Wu
A J Levine
J Lin
C Reichner
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogeneQ24298218
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigenQ24308837
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsQ24314293
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860608
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycleQ28189224
p21 is a universal inhibitor of cyclin kinasesQ28257305
Physical interaction of the retinoblastoma protein with human D cyclinsQ28269103
Cyclin D1 is a nuclear protein required for cell cycle progression in G1Q28269145
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distributionQ28300442
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor geneQ28300451
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigenQ28303106
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activationQ28611416
Induction of apoptosis in fibroblasts by c-myc proteinQ29614346
Suppression of human colorectal carcinoma cell growth by wild-type p53Q29618318
Regulation of retinoblastoma protein functions by ectopic expression of human cyclinsQ29618320
Mammalian G1 cyclinsQ29618855
Functional interactions of the retinoblastoma protein with mammalian D-type cyclinsQ29618856
Wild-type p53 can inhibit oncogene-mediated focus formationQ30450825
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.Q34173355
p53 functions as a cell cycle control protein in osteosarcomasQ34254691
Rearrangement of the p53 gene in human osteogenic sarcomasQ34360802
The p53 proto-oncogene can act as a suppressor of transformationQ34440370
p53 and E2F-1 cooperate to mediate apoptosisQ35185411
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expressionQ36551292
The p53 tumour suppressor geneQ37751892
Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.Q40805671
The tumor suppression function of p21Waf is contained in its N-terminal half ('half-WAF').Q41324287
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.Q41358760
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cellsQ41368682
Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinaseQ41368684
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.Q41368691
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.Q41436520
Cellular localization and cell cycle regulation by a temperature-sensitive p53 proteinQ41696617
Presence of a potent transcription activating sequence in the p53 proteinQ41724404
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast.Q45944819
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.Q45993768
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.Q53505779
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1Q59063779
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical featuresQ67841746
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damageQ72297293
Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitorQ72320119
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1786-1793
P577publication date1996-04-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleAnalysis of wild-type and mutant p21WAF-1 gene activities
P478volume16

Reverse relations

cites work (P2860)
Q38797735A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin
Q33948911Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry
Q40796704Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression
Q74164931Ankyrin for clues about the function of p16INK4a
Q53569604Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways.
Q28533417CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point
Q34981345CDKs and CKIs: molecular targets for tissue remodelling
Q41345498CDKs and cyclins in transition(s).
Q47629898CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene
Q39037303CEP55 contributes to human gastric carcinoma by regulating cell proliferation
Q71985306Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1
Q44557874Constitutive cytoplasmic localization of p21(Waf1/Cip1) affects the apoptotic process in monocytic leukaemia.
Q73023858Control of E2F activity by p21Waf1/Cip1
Q77932294Coordinated changes in cell cycle machinery occur during keratinocyte terminal differentiation
Q42060468Critical role for the 310 helix region of p57(Kip2) in cyclin-dependent kinase 2 inhibition and growth suppression
Q24336704Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
Q24316125Cyclin-binding motifs are essential for the function of p21CIP1
Q36799242Cyclin-dependent kinase inhibitor p20 controls circadian cell-cycle timing.
Q33774973Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex
Q28393323DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry
Q26822413DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis
Q40894496Dimerization of the amino terminal domain of p57Kip2 inhibits cyclin D1-cdk4 kinase activity
Q33778594Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
Q36569390Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
Q38321059Expressions of cyclin E, A, and B1 in Hodgkin and Reed-Sternberg cells: not suppressed by cyclin-dependent kinase inhibitor p21 expression
Q46354780Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-κB/p53 pathway mediated by folic acid receptor
Q36848888Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer
Q28583336Global identification of genes related to nutrient deficiency in intervertebral disc cells in an experimental nutrient deprivation model
Q42812297Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
Q77845951Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
Q41079253Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.
Q36907227Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities
Q39259475Human papillomavirus 18 E1^E4 protein interacts with cyclin A/CDK 2 through an RXL motif
Q40020347Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors
Q37439146Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy
Q39444837Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
Q40643325Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip).
Q34742793Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
Q48243475Interplay between p53 and Ink4c in spermatogenesis and fertility.
Q41193883JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.
Q45757774Lack of mutation in the WAF1/CIP1 gene during bovine leukemia virus-induced leukemogenesis
Q36255453OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner.
Q40790669P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
Q35033462P21Waf1 control of epithelial cell cycle and cell fate
Q28189989Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2)
Q39454436Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins
Q24670485Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis
Q39543452Rapid purification of protein complexes from mammalian cells
Q40243606Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation
Q42055057Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
Q35141843Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis
Q24646032Specific regulation of E2F family members by cyclin-dependent kinases
Q34076012Strategies for manipulating the p53 pathway in the treatment of human cancer.
Q37469268Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.
Q40967344The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
Q39085673Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenance
Q64890070Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer.
Q28647314p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
Q40022880p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases
Q37217826p21WAF1/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters, and Ki67 and p53 gene expression.

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