Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects

scientific article published on July 2004

Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1044711057
P356DOI10.1038/SJ.ONC.1207753
P698PubMed publication ID15184880
P5875ResearchGate publication ID8521962

P2093author name stringLei Li
Xin Wang
Tao Lu
Walter N Hittelman
Li-E Wang
Qingyi Wei
Huyong Zheng
Shilai Bao
P2860cites workHuman homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complexQ22008596
Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpointQ24292703
Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonucleaseQ24321351
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.Q24533460
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firingQ24535710
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitroQ24550745
Purification and characterization of human DNA damage checkpoint Rad complexesQ24555188
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombeQ24607761
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitroQ24656275
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinQ24672721
The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymeraseQ24682656
The DNA damage response: putting checkpoints in perspectiveQ28131713
Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosisQ28141886
PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibitionQ28143834
ATR and ATRIP: partners in checkpoint signalingQ28207471
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cellsQ28215061
14-3-3sigma is a p53-regulated inhibitor of G2/M progressionQ28276061
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathwayQ28513656
ATR Regulates Fragile Site StabilityQ29303576
Cell cycle checkpoints: preventing an identity crisisQ29547644
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpointQ29614219
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
The DNA replication checkpoint response stabilizes stalled replication forksQ29618306
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replicationQ29618307
DNA structure checkpoint pathways in Schizosaccharomyces pombeQ33601103
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexesQ33617643
Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinasesQ33652271
Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complexQ33948751
Fission yeast Rad26 is a regulatory subunit of the Rad3 checkpoint kinaseQ33953683
Replication checkpoint enforced by kinases Cds1 and Chk1.Q34466698
Maintenance of genome stability in Saccharomyces cerevisiaeQ34762852
Genomic instability and endoreduplication triggered by RAD17 deletionQ35964843
Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repairQ38362932
Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9Q39450987
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defectsQ39698998
Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint SignalingQ40653014
Effective expression of small interfering RNA in human cellsQ40735246
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpointsQ41063544
Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint geneQ47949929
A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteinsQ63383723
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanismsQ64388006
P433issue33
P407language of work or nameEnglishQ1860
P304page(s)5586-5593
P577publication date2004-07-01
P1433published inOncogeneQ1568657
P1476titleDisruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects
P478volume23

Reverse relations

cites work (P2860)
Q36910085A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension
Q36023707ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability
Q37470820An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses
Q24298321BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
Q80151856Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome
Q91809305Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death
Q35691004Contributions of Rad9 to tumorigenesis
Q24313157Crystal structure of the human rad9-hus1-rad1 clamp
Q28388312DNA damage response genes and the development of cancer metastasis
Q36402069DNA damage responses and their many interactions with the replication fork
Q39717725Development of bimolecular fluorescence complementation using Dronpa for visualization of protein-protein interactions in cells
Q34797749Differential hRad17 expression by histologic subtype of ovarian cancer.
Q37177317Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase
Q33751277Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania.
Q33235763Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses
Q35676284Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.
Q54525472Glycogen synthase kinase (GSK)-3 and mammalian target of rapamycin complex 1 (mTORC1) cooperate to regulate protein S6 kinase 1 (S6K1).
Q34579692HERC2-USP20 axis regulates DNA damage checkpoint through Claspin
Q39951895Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy
Q27325197Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks
Q34230830Human TopBP1 ensures genome integrity during normal S phase
Q35650781Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells
Q24302320Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
Q37267542Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex
Q37019406Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins
Q37592751NF-kappa B mediated up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia
Q24307904PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130
Q34819494RMI1 attenuates tumor development and is essential for early embryonic survival
Q34306322Removing all obstacles: a critical role for p53 in promoting tissue renewal
Q39869495Role of the checkpoint clamp in DNA damage response
Q35918497TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint
Q36922875Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.
Q35844875The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication
Q34224724The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling
Q90187249The fission yeast FHIT homolog affects checkpoint control of proliferation and is regulated by mitochondrial electron transport
Q24297953The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells
Q37606136The human intra-S checkpoint response to UVC-induced DNA damage
Q24298324srGAP2 Arginine Methylation Regulates Cell Migration and Cell Spreading through Promoting Dimerization

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