Activation of the ATM-Snail pathway promotes breast cancer metastasis

scientific article

Activation of the ATM-Snail pathway promotes breast cancer metastasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JMCB/MJS048
P8608Fatcat IDrelease_rp3d2na3lfapthali3osyx4vse
P932PMC publication ID3464396
P698PubMed publication ID22923499
P5875ResearchGate publication ID230742355

P50authorRichard S JopeQ124296477
P2093author name stringBo Xu
Stephen T C Wong
Haibo Wang
Li Fu
Chunying Yang
Ming Zhan
Xiaojing Guo
David A Engler
Xiaolong Qian
Binhua Zhou
Mianen Sun
Monica Serrano-Gonzalez
Kathryn L Brinkman
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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
Identification of an antiapoptotic protein complex at death receptorsQ24321594
The DNA-damage response in human biology and diseaseQ24606586
Epithelial-mesenchymal transitions in tumour progressionQ27860487
ATM and ATR: networking cellular responses to DNA damageQ28143424
The many substrates and functions of ATMQ28205055
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Correlation of Snail expression with histological grade and lymph node status in breast carcinomasQ28206944
The snail superfamily of zinc-finger transcription factorsQ28216843
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functionsQ28245491
DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award LectureQ28276038
Cell-cycle checkpoints and cancerQ28293996
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?Q29547559
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsQ29614216
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisQ29614217
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATMQ29614843
HSP90 at the hub of protein homeostasis: emerging mechanistic insightsQ29616824
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsQ29617405
Molecular requirements for epithelial-mesenchymal transition during tumor progressionQ29618960
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasionQ30434675
The role of DDX3 in regulating SnailQ34612415
The role of ATM and ATR in the cellular response to hypoxia and re-oxygenationQ35848530
Impact of heat-shock protein 90 on cancer metastasisQ37272247
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancerQ37278036
SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer.Q37329523
Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor SnailQ38301455
Protein Kinase D1 Suppresses Epithelial-to-Mesenchymal Transition through Phosphorylation of SnailQ38340196
Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpointQ39526815
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancerQ39634782
PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage.Q39713494
Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.Q39773128
The basal flux of Akt in the mitochondria is mediated by heat shock protein 90.Q39888512
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosisQ40028787
Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancerQ40238962
ATM activation in normal human tissues and testicular cancerQ40428814
Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.Q40550039
Immunohistochemical detection of ornithine-decarboxylase in primary and metastatic human breast cancer specimensQ40689957
The kinetochore protein Bub1 participates in the DNA damage responseQ42124109
Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivoQ42166898
Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancerQ42855720
A DNA damage response pathway controlled by Tel1 and the Mre11 complexQ64388109
Wnt-dependent regulation of the E-cadherin repressor snailQ81263727
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
cancer metastasisQ120912394
P304page(s)304-315
P577publication date2012-08-24
P1433published inJournal of Molecular Cell BiologyQ2456339
P1476titleActivation of the ATM-Snail pathway promotes breast cancer metastasis
P478volume4

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