| scholarly article | Q13442814 |
| P2093 | author name string | Qinghua Liu | |
| Stephen J Elledge | |||
| Jeffrey M Rosen | |||
| Michael H Lam | |||
| P433 | issue | 1 | |
| P921 | main subject | haploinsufficiency | Q852654 |
| P304 | page(s) | 45-59 | |
| P577 | publication date | 2004-07-01 | |
| P1433 | published in | Cancer Cell | Q280018 |
| P1476 | title | Chk1 is haploinsufficient for multiple functions critical to tumor suppression | |
| P478 | volume | 6 |
| Q36279546 | "The Octet": Eight Protein Kinases that Control Mammalian DNA Replication. |
| Q40495288 | A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer |
| Q36382754 | ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection |
| Q33396987 | ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress |
| Q34025378 | Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci |
| Q35825997 | An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation |
| Q90401606 | Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways |
| Q33635896 | Ataxin-3 promotes genome integrity by stabilizing Chk1. |
| Q39303724 | Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1 |
| Q37297138 | BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells |
| Q33252066 | BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer |
| Q34085175 | BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly |
| Q92320326 | Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions |
| Q50423666 | CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice |
| Q92512509 | CHK1 dosage in germinal center B cells controls humoral immunity |
| Q38965035 | CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress. |
| Q36340540 | CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells |
| Q41840512 | CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction |
| Q22242922 | Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability |
| Q34394094 | Causes and consequences of replication stress |
| Q37187614 | Cell cycle regulation by checkpoints |
| Q28293996 | Cell-cycle checkpoints and cancer |
| Q37941374 | Checkpoint control and cancer. |
| Q35033125 | Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1) |
| Q35657580 | Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints |
| Q28287480 | Checkpoint kinase 1 in DNA damage response and cell cycle regulation |
| Q92399928 | Checkpoint kinase 1 is essential for fetal and adult hematopoiesis |
| Q28265625 | Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes |
| Q48250645 | Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis. |
| Q38594084 | Checkpoint kinase 1 negatively regulates somatic hypermutation |
| Q35273933 | Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation |
| Q24537422 | Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress |
| Q42118108 | Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation |
| Q33522243 | Chk1 haploinsufficiency results in anemia and defective erythropoiesis |
| Q53283803 | Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. |
| Q50750100 | Chk1 is essential for the development of murine epidermal melanocytes |
| Q41847676 | Chk1 regulates the density of active replication origins during the vertebrate S phase. |
| Q21203552 | Chk1 suppressed cell death |
| Q39977339 | Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. |
| Q35925425 | Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells |
| Q53354195 | Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals |
| Q28269044 | Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway |
| Q90481284 | Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma |
| Q53397319 | Computational studies on the binding mechanism between triazolone inhibitors and Chk1 by molecular docking and molecular dynamics |
| Q34241074 | Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo |
| Q36127125 | Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability |
| Q35676646 | Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. |
| Q39294122 | Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. |
| Q37778009 | DNA Damage and Polyploidization |
| Q42735492 | DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation |
| Q28388312 | DNA damage response genes and the development of cancer metastasis |
| Q37233544 | DNA replication in early S phase pauses near newly activated origins |
| Q38652528 | DNA replication stress and cancer: cause or cure? |
| Q24529007 | DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system |
| Q28298703 | Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics |
| Q39763066 | Delisheng, a Chinese medicinal compound, exerts anti-proliferative and pro-apoptotic effects on HepG2 cells through extrinsic and intrinsic pathways |
| Q40373985 | Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe |
| Q38507121 | Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells |
| Q36823692 | Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit |
| Q37482118 | Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration |
| Q36556389 | Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines |
| Q98513568 | Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| Q37081706 | Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control |
| Q37142957 | Expanded roles for Chk1 in genome maintenance |
| Q38022941 | Exploiting Synthetic Lethal Interactions Between DNA Damage Signaling, Checkpoint Control, and p53 for Targeted Cancer Therapy |
| Q37597842 | Exploiting synthetic lethal interactions for targeted cancer therapy |
| Q34761951 | Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. |
| Q33693027 | Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model |
| Q46605059 | Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53. |
| Q52716571 | Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion |
| Q35843205 | Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome. |
| Q37188498 | Glucose deprivation is associated with Chk1 degradation through the ubiquitin–proteasome pathway and effective checkpoint response to replication blocks |
| Q28294885 | HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability |
| Q48195510 | HUS1 regulates in vivo responses to genotoxic chemotherapies |
| Q37185705 | Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders |
| Q41932257 | Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An in silico Approach |
| Q38937094 | Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin |
| Q34072906 | Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response |
| Q37347028 | In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets |
| Q39285948 | Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress |
| Q31160033 | Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage |
| Q48012870 | Insulin-like Growth Factor 1 Receptor Signaling Is Required for Optimal ATR-CHK1 Kinase Signaling in Ultraviolet B (UVB)-irradiated Human Keratinocytes. |
| Q35983115 | Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA. |
| Q34609906 | Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages |
| Q64947321 | Large-scale gene expression analysis reveals robust gene signatures for prognosis prediction in lung adenocarcinoma. |
| Q56930964 | Life can be stressful without ATR |
| Q33708170 | MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers |
| Q37477525 | MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1. |
| Q34572690 | Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast |
| Q37089955 | MicroRNA-376a sensitizes cells following DNA damage by downregulating MEPE expression |
| Q33381633 | Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress |
| Q28592252 | Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells |
| Q36118418 | New opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response |
| Q28262425 | Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy? |
| Q35640593 | Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR |
| Q64113941 | Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner |
| Q39983068 | Pathways to chromothripsis |
| Q42354761 | Quercetin enhances the effects of 5-fluorouracil-mediated growth inhibition and apoptosis of esophageal cancer cells by inhibiting NF-κB. |
| Q34602599 | RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma |
| Q59135972 | Role of Chk1 in the differentiation program of hematopoietic stem cells |
| Q28289548 | Roles of Chk1 in cell biology and cancer therapy |
| Q37936675 | Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication |
| Q36618648 | Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts |
| Q43248906 | Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability |
| Q33999750 | Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation |
| Q38912800 | Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis |
| Q36054977 | Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells |
| Q53526225 | TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma |
| Q37497709 | Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response |
| Q35667126 | Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival |
| Q39383614 | Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth |
| Q47120183 | Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer |
| Q37659687 | Targeting the checkpoint kinase Chk1 in cancer therapy |
| Q36664049 | The ATR barrier to replication-born DNA damage. |
| Q34170839 | The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner |
| Q39769852 | The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. |
| Q38448884 | The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression |
| Q30486781 | The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis |
| Q24652535 | The combined status of ATM and p53 link tumor development with therapeutic response |
| Q35205026 | The fork and the kinase: a DNA replication tale from a CHK1 perspective |
| Q34107413 | The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation |
| Q89207234 | The organization of genome duplication is a critical determinant of the landscape of genome maintenance |
| Q54538558 | Thresholds of replication stress signaling in cancer development and treatment |
| Q35653663 | Tight Chk1 Levels Control Replication Cluster Activation in Xenopus |
| Q39697685 | Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange |
| Q84072304 | Transient knock down of checkpoint kinase 1 in hematopoietic progenitors is linked to bone marrow toxicity |
| Q26745686 | Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy |
| Q36252762 | Tumor suppressor genetics |
| Q39795664 | U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint |
| Q36454659 | Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition |
| Q33672284 | Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage |
| Q28513601 | VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling |
| Q33778215 | Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response |
| Q44513883 | Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency |
| Q37342444 | p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage |
Search more.