| P50 | author | Thomas Helleday | Q28320737 |
| | Eva Petermann | Q51806559 |
| P2093 | author name string | Deborah Wilsker | |
| | Fred Bunz | |
| P2860 | cites work | Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase | Q24301325 |
| | Active cyclin B1-Cdk1 first appears on centrosomes in prophase | Q24338617 |
| | Improved methods for the generation of human gene knockout and knockin cell lines | Q24535648 |
| | ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 | Q24550952 |
| | Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint | Q24604730 |
| | Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance | Q24672646 |
| | The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation | Q27622198 |
| | Regulating mammalian checkpoints through Cdc25 inactivation | Q28387035 |
| | ATR disruption leads to chromosomal fragmentation and early embryonic lethality | Q28591433 |
| | Rapid destruction of human Cdc25A in response to DNA damage | Q28611930 |
| | Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage | Q31160033 |
| | Chk1 is haploinsufficient for multiple functions critical to tumor suppression | Q34334239 |
| | Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase | Q34563205 |
| | Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1) | Q35033125 |
| | Specific role of Chk1 phosphorylations in cell survival and checkpoint activation | Q35856701 |
| | Structure meets function--centrosomes, genome maintenance and the DNA damage response | Q36541054 |
| | Exercising restraints: role of Chk1 in regulating the onset and progression of unperturbed mitosis in vertebrate cells | Q36766405 |
| | G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer | Q37071564 |
| | Essential role of Chk1 in S phase progression through regulation of RNR2 expression | Q39962974 |
| | Genetic knockouts and knockins in human somatic cells | Q40050373 |
| | DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function | Q40088175 |
| | Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival | Q40146288 |
| | Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. | Q40339254 |
| | Lack of PTEN sequesters CHK1 and initiates genetic instability. | Q40458578 |
| | Chk1 regulates the density of active replication origins during the vertebrate S phase. | Q41847676 |
| | Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. | Q42439288 |
| | Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation | Q44317026 |
| | Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). | Q51808299 |
| | Spreading the signal: dissociation of Chk1 from chromatin. | Q53621329 |
| | Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation | Q64388257 |
| P433 | issue | 52 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | DNA damage | Q5205747 |
| P304 | page(s) | 20752-20757 | |
| P577 | publication date | 2008-12-17 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control | |
| P478 | volume | 105 | |