| scholarly article | Q13442814 |
| P50 | author | Jeffrey B Travers | Q56946935 |
| Michael G Kemp | Q61123614 | ||
| P2093 | author name string | Dan F Spandau | |
| P2860 | cites work | Replication fork barriers: pausing for a break or stalling for time? | Q36777307 |
| ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress | Q36884873 | ||
| ATR signalling: more than meeting at the fork | Q36918246 | ||
| Direct Role for the Replication Protein Treslin (Ticrr) in the ATR Kinase-mediated Checkpoint Response | Q36967311 | ||
| ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells | Q36976753 | ||
| ATR phosphorylates SMARCAL1 to prevent replication fork collapse | Q37064611 | ||
| The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. | Q37088112 | ||
| Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo | Q37175091 | ||
| Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution | Q37181911 | ||
| How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. | Q37290578 | ||
| Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution | Q37346994 | ||
| High-resolution characterization of CPD hotspot formation in human fibroblasts | Q37518592 | ||
| Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system | Q37596367 | ||
| The human intra-S checkpoint response to UVC-induced DNA damage | Q37606136 | ||
| Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells | Q37606890 | ||
| Detection of the Excised, Damage-containing Oligonucleotide Products of Nucleotide Excision Repair in Human Cells | Q37650502 | ||
| A new paradigm for the role of aging in the development of skin cancer | Q37707329 | ||
| Bipyrimidine Photoproducts Rather than Oxidative Lesions Are the Main Type of DNA Damage Involved in the Genotoxic Effect of Solar UVA Radiation † | Q22162468 | ||
| ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage | Q24306743 | ||
| RPA involvement in the damage-recognition and incision steps of nucleotide excision repair | Q24312764 | ||
| Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. | Q24522744 | ||
| ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 | Q24550952 | ||
| Skin resurfacing procedures: new and emerging options | Q24563693 | ||
| Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint | Q24604730 | ||
| An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair | Q24651193 | ||
| Cdc7-Dbf4 and the human S checkpoint response to UVC | Q24672815 | ||
| The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement | Q24683336 | ||
| RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response | Q26827954 | ||
| Nucleotide excision repair in eukaryotes | Q26850656 | ||
| RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA | Q27314893 | ||
| Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes | Q27860662 | ||
| The DNA Damage Response: Making It Safe to Play with Knives | Q27861055 | ||
| Replication fork instability and the consequences of fork collisions from rereplication | Q28076969 | ||
| Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints | Q28214430 | ||
| REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism | Q28245231 | ||
| Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25 | Q28247761 | ||
| Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints | Q28266170 | ||
| ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background | Q28274709 | ||
| ATR disruption leads to chromosomal fragmentation and early embryonic lethality | Q28591433 | ||
| Activation of the ATR kinase by the RPA-binding protein ETAA1 | Q28596569 | ||
| ETAA1 acts at stalled replication forks to maintain genome integrity | Q28596606 | ||
| DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair | Q28628567 | ||
| ATR: an essential regulator of genome integrity | Q29547883 | ||
| A dynamic model for replication protein A (RPA) function in DNA processing pathways | Q29614213 | ||
| Replication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA. | Q30631650 | ||
| Signalling by insulin and IGF receptors: supporting acts and new players | Q37865971 | ||
| Physiological changes in ageing skin | Q37922274 | ||
| Replication of Damaged Genomes | Q37969795 | ||
| Translesion DNA synthesis and mutagenesis in eukaryotes | Q38086224 | ||
| Solar UV radiation-induced DNA Bipyrimidine photoproducts: formation and mechanistic insights | Q38265062 | ||
| Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease | Q38357913 | ||
| Inhibition and recovery of DNA synthesis in human cells after exposure to ultraviolet light | Q38521196 | ||
| Ultraviolet radiation inhibits replicon initiation in S phase human cells | Q38524631 | ||
| ATR inhibition rewires cellular signaling networks induced by replication stress | Q38819342 | ||
| Chemical excitation of electrons: A dark path to melanoma | Q38854948 | ||
| Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture). | Q38874687 | ||
| Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. | Q38923378 | ||
| PostExcision Events in Human Nucleotide Excision Repair | Q38958950 | ||
| The Cartography of UV-induced DNA Damage Formation and DNA Repair. | Q39012858 | ||
| Effects of Aging and Chronic Sun Exposure on Melanocytes in Human Skin | Q39554749 | ||
| Structural and functional changes of normal aging skin | Q39746062 | ||
| Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints | Q41063544 | ||
| Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNA damage in human keratinocytes in vivo. | Q41113979 | ||
| In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors | Q41626903 | ||
| Replication protein A safeguards genome integrity by controlling NER incision events | Q42090929 | ||
| The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. | Q42123048 | ||
| Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study | Q42460229 | ||
| Aged human skin removes UVB-induced pyrimidine dimers from the epidermis more slowly than younger adult skin in vivo. | Q42487417 | ||
| High sun protection factor sunscreens in the suppression of actinic neoplasia | Q42489126 | ||
| G2 phase cell cycle arrest in human skin following UV irradiation. | Q42511176 | ||
| Acceleration of 5-methylcytosine deamination in cyclobutane dimers by G and its implications for UV-induced C-to-T mutation hotspots | Q42579444 | ||
| Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin | Q42816906 | ||
| Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo | Q47609025 | ||
| Insulin-like Growth Factor 1 Receptor Signaling Is Required for Optimal ATR-CHK1 Kinase Signaling in Ultraviolet B (UVB)-irradiated Human Keratinocytes. | Q48012870 | ||
| Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. | Q52536369 | ||
| Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans | Q53238461 | ||
| Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. | Q53283803 | ||
| Checkpoint regulation of replication dynamics in UV-irradiated human cells | Q53599798 | ||
| Suppressing cancer: the importance of being senescent | Q53663083 | ||
| Insulin-like growth factor-I and UVB photoprotection in human keratinocytes. | Q54295573 | ||
| Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions | Q54583234 | ||
| Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation. | Q54644929 | ||
| DNA repair in late-passage human cells | Q67445532 | ||
| Variations in Excision Repair of UVB-Induced Pyrimidine Dimers in DNA of Human Skin in Situ | Q68370650 | ||
| Skin thickness changes in normal aging skin | Q68883340 | ||
| In vivo evidence that UV-induced C-->T mutations at dipyrimidine sites could result from the replicative bypass of cis-syn cyclobutane dimers or their deamination products | Q70534579 | ||
| Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migration | Q70711804 | ||
| Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts | Q71009312 | ||
| Early Effects of Ultraviolet Light on DNA Synthesis in Human Skin in Vivo | Q72534542 | ||
| Measurement of biological ageing in human epidermis | Q72638284 | ||
| Effect of age on the formation and repair of UV photoproducts in human skin in situ | Q73795294 | ||
| Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation | Q77959372 | ||
| Transcription - guarding the genome by sensing DNA damage | Q80518102 | ||
| ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation | Q95721661 | ||
| Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation | Q35170755 | ||
| Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase | Q35171016 | ||
| The fork and the kinase: a DNA replication tale from a CHK1 perspective | Q35205026 | ||
| Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication | Q35205336 | ||
| Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts | Q35206290 | ||
| Sites of termination of in vitro DNA synthesis on ultraviolet- and N-acetylaminofluorene-treated phi X174 templates by prokaryotic and eukaryotic DNA polymerases | Q35300157 | ||
| Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation. | Q35583204 | ||
| What has senescence got to do with cancer? | Q35585808 | ||
| Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells | Q35680926 | ||
| Mutations in Replicative Stress Response Pathways Are Associated with S Phase-specific Defects in Nucleotide Excision Repair | Q35844580 | ||
| Sunlight and skin cancer: another link revealed | Q36001068 | ||
| Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage. | Q36003562 | ||
| The signals and pathways activating cellular senescence | Q36060167 | ||
| Ultraviolet radiation-mediated damage to cellular DNA. | Q36062298 | ||
| Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair | Q36080510 | ||
| RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response | Q36183806 | ||
| How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling | Q36191375 | ||
| Nucleotide excision repair | Q36226849 | ||
| CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation | Q36280773 | ||
| Profiling of UV-induced ATM/ATR signaling pathways. | Q36288898 | ||
| An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells: NUCLEOTIDE EXCISION REPAIR, DNA DAMAGE CHECKPOINT, AND APOPTOSIS | Q36323445 | ||
| ATR signaling can drive cells into senescence in the absence of DNA breaks | Q36411149 | ||
| Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control | Q36490482 | ||
| Measuring the Formation and Repair of UV Damage at the DNA Sequence Level by Ligation-Mediated PCR | Q36528506 | ||
| UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. | Q36536607 | ||
| Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA. | Q36699598 | ||
| Elderly skin and its rejuvenation: products and procedures for the aging skin | Q36755894 | ||
| Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure | Q30650674 | ||
| RPA stabilizes the XPA-damaged DNA complex through protein-protein interaction | Q30873590 | ||
| Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease | Q31004989 | ||
| Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A. | Q31148707 | ||
| Order of assembly of human DNA repair excision nuclease | Q31326797 | ||
| Assembly, subunit composition, and footprint of human DNA repair excision nuclease | Q32061670 | ||
| Functional Analysis of Human Replication Protein A in Nucleotide Excision Repair | Q32069526 | ||
| The transcription stress response | Q33294227 | ||
| The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling | Q33378038 | ||
| Chemical peels, dermabrasion, and laser therapy | Q33418158 | ||
| PCR-based approaches to adduct analysis | Q33534050 | ||
| Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress | Q33541382 | ||
| Replication protein A: directing traffic at the intersection of replication and repair | Q33591901 | ||
| ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine | Q33691507 | ||
| The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. | Q33721751 | ||
| Endonuclease from Micrococcus luteus which has activity toward ultraviolet-irradiated deoxyribonucleic acid: its action on transforming deoxyribonucleic acid | Q33770798 | ||
| Fibroblast Senescence and Squamous Cell Carcinoma: How Wounding Therapies Could Be Protective | Q33954838 | ||
| Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene | Q34058543 | ||
| Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin | Q34179222 | ||
| DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair | Q34249149 | ||
| Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. | Q34325779 | ||
| Chk1 is haploinsufficient for multiple functions critical to tumor suppression | Q34334239 | ||
| Reduction of solar keratoses by regular sunscreen use. | Q34354861 | ||
| Translesion DNA Polymerases | Q34356338 | ||
| Understanding nucleotide excision repair and its roles in cancer and ageing. | Q34426055 | ||
| An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage | Q34443534 | ||
| The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism | Q34557750 | ||
| Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation. | Q34563627 | ||
| The structural determinants of checkpoint activation | Q34619662 | ||
| Changes in DNA repair during aging. | Q34697935 | ||
| UV signature mutations | Q34963798 | ||
| Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity | Q35006896 | ||
| ATR prohibits replication catastrophe by preventing global exhaustion of RPA. | Q35051406 | ||
| Reversing the aging stromal phenotype prevents carcinoma initiation | Q35052087 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | peptide | Q172847 |
| somatomedin receptors | Q7559298 | ||
| membrane protein | Q423042 | ||
| blood proteins | Q425056 | ||
| integumentary system | Q483213 | ||
| cell surface receptor | Q2476074 | ||
| DNA damage | Q5205747 | ||
| P577 | publication date | 2017-02-26 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Molecules | Q151332 |
| P1476 | title | Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin | |
| P478 | volume | 22 |
| Q90011526 | Growth Hormone Induces Colon DNA Damage Independent of IGF-1 |
| Q55143866 | Involvement of SPATA31 copy number variable genes in human lifespan. |
| Q90357936 | Quantifying skin photodamage with spatial frequency domain imaging: statistical results |
| Q91628294 | Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction |
| Q54983880 | Roles of UVA radiation and DNA damage responses in melanoma pathogenesis. |
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