Replication protein A: directing traffic at the intersection of replication and repair

scientific article

Replication protein A: directing traffic at the intersection of replication and repair is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2741/3652
P932PMC publication ID3399740
P698PubMed publication ID20515732
P5875ResearchGate publication ID44642779

P50authorGregory OakleyQ42678621
P2093author name stringSteve M Patrick
P2860cites workThe crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA bindingQ22003743
Replication protein A stimulates long patch DNA base excision repairQ22003913
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activityQ22254162
Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2Q24292684
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPAQ24293001
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeresQ24298583
Mechanism of 5'-directed excision in human mismatch repairQ24300483
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cellsQ24302320
ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiationQ24305520
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicasesQ24305559
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cellsQ24311394
Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNAQ24311910
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repairQ24312736
RPA involvement in the damage-recognition and incision steps of nucleotide excision repairQ24312764
Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNAQ24314908
Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complexQ24316902
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitroQ24319018
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restartQ24319812
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPAQ24319860
The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repairQ24321288
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damageQ24321669
Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigenQ24324896
A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repairQ24337036
RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cellsQ24338859
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.Q24522744
Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk.Q24533333
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexesQ24533892
Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damageQ24537139
Identification of DNA replication and cell cycle proteins that interact with PCNAQ24545747
Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinaseQ24554245
cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replicationQ24555683
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replicationQ24561565
Replication protein A-mediated recruitment and activation of Rad17 complexesQ24631467
Human CtIP promotes DNA end resectionQ24646062
Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeastQ24672331
The comings and goings of nucleotide excision repair factors on damaged DNAQ24672395
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacementQ24683336
Human replication protein A: global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linkerQ27620027
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPAQ27628426
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structureQ27639649
RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions.Q30899111
The Recombination-deficient Mutant RPA (rfa1-t11) Is Displaced Slowly from Single-stranded DNA by Rad51 ProteinQ30917944
The phosphorylation domain of the 32-kDa subunit of replication protein A (RPA) modulates RPA-DNA interactions. Evidence for an intersubunit interactionQ30951152
The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA bindingQ30997034
Mechanism underlying replication protein a stimulation of DNA ligase I.Q31028860
Xeroderma pigmentosum complementation group A protein (XPA) modulates RPA-DNA interactions via enhanced complex stability and inhibition of strand separation activityQ31039442
Replication protein A (RPA) phosphorylation prevents RPA association with replication centersQ31048017
Interactions of human replication protein A with single-stranded DNA adductsQ31111443
Independent and coordinated functions of replication protein A tandem high affinity single-stranded DNA binding domainsQ31150799
Identification and characterization of the fourth single-stranded-DNA binding domain of replication protein AQ31973924
Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinasesQ32028781
Human replication protein A preferentially binds cisplatin-damaged duplex DNA in vitroQ32060923
Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolismQ32068528
Functional analysis of human replication protein A in nucleotide excision repairQ32069526
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.Q33197915
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forksQ33203493
A hypophosphorylated form of RPA34 is a specific component of pre-replication centersQ33207491
Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.Q33218577
Reconstitution of 5'-directed human mismatch repair in a purified systemQ33222844
The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathwayQ33232869
UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.Q33235625
Regulation of replication protein A functions in DNA mismatch repair by phosphorylationQ33244982
Different requirements for the association of ATR-ATRIP and 9-1-1 to the stalled replication forksQ33245762
Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctionsQ33251608
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancerQ33252066
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpointQ33260135
Function of a conserved checkpoint recruitment domain in ATRIP proteinsQ33276978
Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere lossQ33281857
Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular rulerQ33288423
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.Q33288787
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding proteinQ33289084
Sequential and synergistic modification of human RPA stimulates chromosomal DNA repairQ33302234
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapseQ33305608
Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairQ27657670
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human ArtemisQ27919681
DNA-PK autophosphorylation facilitates Artemis endonuclease activityQ27919702
Uninterrupted MCM2-7 function required for DNA replication fork progressionQ27929772
Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replicationQ27930450
A hierarchy of SSB protomers in replication protein A.Q27932319
Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatinQ27933399
RPA regulates telomerase action by providing Est1p access to chromosome endsQ27933681
Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.Q27937193
Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturationQ27939444
DNA replication in eukaryotic cellsQ28131747
Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repairQ28138546
Substrate specificities and identification of putative substrates of ATM kinase family membersQ28141080
Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extractsQ28142871
Molecular views of recombination proteins and their controlQ28207872
Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNAQ28215930
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolismQ28245231
53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damageQ28247101
Reconstitution of complete SV40 DNA replication with purified replication factorsQ28251397
Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein AQ28260499
The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domainQ28261426
Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatinQ28269485
Replication protein A phosphorylation and the cellular response to DNA damageQ28274289
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signalsQ28292900
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein AQ28304314
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaksQ28609912
Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activitiesQ28610054
Human replication protein A binds single-stranded DNA in two distinct complexesQ28610087
Sequential assembly of the nucleotide excision repair factors in vivoQ28610121
Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein AQ28610670
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repairQ28628567
Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repairQ28645707
Polarity of human replication protein A binding to DNAQ28647355
Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanismsQ36869823
Mechanism of open complex and dual incision formation by human nucleotide excision repair factorsQ36888668
SSB protein diffusion on single-stranded DNA stimulates RecA filament formation.Q37435878
Binding properties of replication protein A from human and yeast cellsQ38327986
Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nucleaseQ38357913
Single-stranded DNA binding proteins required for DNA replicationQ39740421
Denaturation of the simian virus 40 origin of replication mediated by human replication protein A.Q40022682
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.Q40028909
Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survivalQ40146288
The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cellsQ40656810
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choiceQ40701520
UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding proteinQ40791755
Reconstitution of human DNA repair excision nuclease in a highly defined systemQ41370395
Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycleQ43515131
Binding of human single-stranded DNA binding protein to DNA damaged by the anticancer drug cis-diamminedichloroplatinum (II).Q43648932
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.Q43814418
DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombinationQ44643710
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junctionQ45345099
Identification of cellular proteins required for simian virus 40 DNA replicationQ45846424
Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cellsQ46342912
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activityQ47618273
Dynamic regulatory interactions of rad51, rad52, and replication protein-a in recombination intermediatesQ47791095
DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimerQ64388960
5' --> 3' molecular polarity of human replication protein A (hRPA) binding to pseudo-origin DNA substratesQ73015510
Est1 and Cdc13 as comediators of telomerase accessQ73042124
Replication protein A as a "fidelity clamp" for DNA polymerase alphaQ73693384
SSB as an organizer/mobilizer of genome maintenance complexesQ79661973
Human replication protein A unfolds telomeric G-quadruplexesQ29147418
Mechanism of eukaryotic homologous recombinationQ29547709
A dynamic model for replication protein A (RPA) function in DNA processing pathwaysQ29614213
OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequencesQ29620102
Prediction of and experimental support for the three-dimensional structure of replication protein A.Q30379128
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein AQ30446685
Replication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA.Q30631650
Recognition of nonhybridizing base pairs during nucleotide excision repair of DNAQ30639682
Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damageQ30643449
Stopped-flow kinetic analysis of replication protein A-binding DNA: damage recognition and affinity for single-stranded DNA reveal differential contributions of k(on) and k(off) rate constantsQ30661563
UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.Q30662249
Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding/helix-destabilization activities and the role of the zinc-finger domain in DNA interactionsQ30668737
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repairQ30684974
Functional analysis of the four DNA binding domains of replication protein A. The role of RPA2 in ssDNA bindingQ30695523
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotesQ30704734
Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitroQ30727947
DNA replication: partners in the Okazaki two-stepQ30755185
NFBD1/Mdc1 mediates ATR-dependent DNA damage responseQ30778870
Adozelesin triggers DNA damage response pathways and arrests SV40 DNA replication through replication protein A inactivationQ30831380
Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance.Q30846929
DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repairQ30854499
The role for zinc in replication protein A.Q30880137
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.Q33310273
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosineQ33315217
Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA)Q33339291
Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activityQ33360205
RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damageQ33362855
The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signalingQ33378038
Replication protein A modulates the activity of human telomerase in vitroQ33411023
Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repairQ33465403
Human replication protein A-Rad52-single-stranded DNA complex: stoichiometry and evidence for strand transfer regulation by phosphorylationQ33468536
Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.Q33479706
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosisQ33492639
Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell linesQ33507350
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forksQ33507753
The annealing helicase HARP protects stalled replication forksQ33507756
Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA.Q33566767
An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A.Q33920913
Base excision repair of DNA in mammalian cellsQ33957142
Multiple functions of human single-stranded-DNA binding protein in simian virus 40 DNA replication: single-strand stabilization and stimulation of DNA polymerases alpha and deltaQ34325040
Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitroQ34424988
Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cellsQ34439017
Replication of simian virus 40 origin-containing DNA in vitro with purified proteinsQ34607996
Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinaseQ35697564
Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repairQ35856732
Cellular factors required for multiple stages of SV40 DNA replication in vitroQ35981213
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindleQ36234928
Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinaseQ36562044
Microcephalin: a causal link between impaired damage response signalling and microcephalyQ36653018
Mammalian DNA nucleotide excision repair reconstituted with purified protein components.Q36697936
Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA.Q36699598
Replication protein A mutants lacking phosphorylation sites for p34cdc2 kinase support DNA replication.Q36723774
The transactivator proteins VP16 and GAL4 bind replication factor A.Q36785332
Replication protein A induces the unwinding of long double-stranded DNA regionsQ36801025
Dissection of functional domains of the human DNA replication protein complex replication protein A.Q36802969
An affinity of human replication protein A for ultraviolet-damaged DNA.Q36805976
P304page(s)883-900
P577publication date2010-06-01
P1433published inFrontiers in BioscienceQ5506062
P1476titleReplication protein A: directing traffic at the intersection of replication and repair
P478volume15

Reverse relations

cites work (P2860)
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