Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA

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Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...624848L
P356DOI10.1371/JOURNAL.PONE.0024848
P932PMC publication ID3174200
P698PubMed publication ID21935481
P5875ResearchGate publication ID51659302

P2093author name stringArtem G Lada
Igor B Rogozin
Youri I Pavlov
Gloria E O Borgstahl
Aishwarya Prakash
Irina S-R Waisertreiger
Corinn E Grabow
P2860cites workHuman retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodiesQ21090536
APOBEC3 proteins mediate the clearance of foreign DNA from human cellsQ24294583
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Q24307678
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseQ24683335
Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesQ24814190
DNA deamination mediates innate immunity to retroviral infectionQ28179534
Death by deamination: a novel host restriction system for HIV-1Q28201173
HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular StabilityQ28207304
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationQ28208979
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolismQ28245231
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimineQ29616154
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genomeQ29618742
Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localizationQ30483676
Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityQ30502490
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceQ30857687
Replication protein A interacts with AID to promote deamination of somatic hypermutation targetsQ31099047
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminaseQ33283188
Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminaseQ33328760
Human replication protein A-Rad52-single-stranded DNA complex: stoichiometry and evidence for strand transfer regulation by phosphorylationQ33468536
Replication protein A: directing traffic at the intersection of replication and repairQ33591901
Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminasesQ33731838
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytesQ33757410
APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeastQ33892198
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Q33957827
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombinationQ34217718
Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granulesQ34590679
DNA-cytosine deaminases: from antibody maturation to antiviral defenseQ35617308
DNA deamination in immunity: AID in the context of its APOBEC relatives.Q36845658
Role of AID in tumorigenesisQ36845685
Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.Q37140478
Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coliQ37312238
Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.Q37532179
The nuclear DNA deaminase AID functions distributively whereas cytoplasmic APOBEC3G has a processive mode of actionQ38306629
Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminaseQ39935230
Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding.Q40029354
APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA.Q40290523
Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localizationQ40493589
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminaseQ40515192
Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactionsQ41902384
Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA.Q42586858
Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracilsQ43279438
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutationQ44486460
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivoQ44799102
Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient miceQ45286129
MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversificationQ46802323
High rate of starvation-associated mutagenesis in Ung(-) yeast caused by the overproduction of human activation-induced deaminaseQ46952641
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genesQ47982616
Death by DeaminationQ55865496
Similarity pattern analysis in mutational distributionsQ73258486
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)e24848
P577publication date2011-09-15
P1433published inPLOS OneQ564954
P1476titleReplication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA
P478volume6

Reverse relations

cites work (P2860)
Q21203746AID/APOBEC cytosine deaminase induces genome-wide kataegis
Q28272805APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication
Q34090613Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness
Q34328211Conformation effects of CpG methylation on single-stranded DNA oligonucleotides: analysis of the opioid peptide dynorphin-coding sequences
Q35590948DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA.
Q28547015Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes
Q47152216Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.
Q28536837Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase
Q35868407Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86.
Q37483304Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools
Q26823568Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
Q58866812Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity
Q37518666Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties
Q35986599Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination

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