Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

scientific article published on 10 October 2012

Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EM.21735
P932PMC publication ID3893020
P698PubMed publication ID23055184
P5875ResearchGate publication ID232231811

P50authorElena StepchenkovaQ57009245
Igor B. RogozinQ45324573
P2093author name stringYouri I Pavlov
Tahir H Tahirov
Hyun-Min Kim
Irina S-R Waisertreiger
Kirill S Lobachev
Miriam R Menezes
Victoria G Liston
P2860cites workBase analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerasesQ71239708
Mutagenicity of 5-bromouracil and N6-hydroxyadenine studied by yeast oligonucleotide transformation assayQ71628566
Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase alphaQ72068723
The mutator mut7-1 of Saccharomyces cerevisiaeQ72091935
The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiaeQ72240900
Calf thymus DNA polymerase alpha-primase: "communication" and primer-template movement between the two active sitesQ72266517
Mutational spectrum induced in Saccharomyces cerevisiae by the carcinogen N-2-acetylaminofluoreneQ72519717
Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the URA3 gene of the yeast Saccharomyces cerevisiaeQ72583801
Similarity pattern analysis in mutational distributionsQ73258486
POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathwayQ73319794
Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiaeQ73420352
Defective DNA polymerase-delta proofreading causes cancer susceptibility in miceQ73954766
The Mutation Rate and CancerQ74481910
Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeastQ74801806
The Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) BindingQ79241756
Insights into DNA deaminasesQ79487889
Toward a unified theory for repeat expansionsQ80998259
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase deltaQ82346662
Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication originQ95816567
Reconstitution of 5'-directed human mismatch repair in a purified systemQ33222844
Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alphaQ33228026
The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.Q33257520
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.Q33300908
Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminaseQ33328760
Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesisQ33494212
Human cancers express mutator phenotypes: origin, consequences and targetingQ33554201
A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instabilityQ33591410
Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis.Q33601912
Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiaeQ33628462
Genome-wide model for the normal eukaryotic DNA replication fork.Q33704744
Break-induced replication is highly inaccurateQ33828325
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loadingQ33888634
Completion of Replication Map ofSaccharomyces cerevisiaeChromosome IIIQ33948459
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
DNA synthesis errors associated with double-strand-break repairQ33965497
A Role for REV3 in Mutagenesis During Double-Strand Break Repair in Saccharomyces cerevisiaeQ33971118
Different Rates of Spontaneous Mutation during Mitosis and Meiosis in YeastQ33979691
Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNAQ34026341
Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletionsQ34082583
DNA mismatch repair and genetic instabilityQ34090778
Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Q34098247
Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiaeQ34132013
Genome instability due to ribonucleotide incorporation into DNA.Q34142849
Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.Q34147661
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.Q34154888
DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiencyQ34159410
hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsQ34161894
Mutagenesis and deoxyribonucleotide pool imbalanceQ34172708
Pivotal Role of Inosine Triphosphate Pyrophosphatase in Maintaining Genome Stability and the Prevention of Apoptosis in Human CellsQ34182512
Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase IQ34195091
Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.Q34274334
Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeastQ34324101
Dynamic protein interactions in the bacteriophage T4 replisome.Q34365405
Structure-based identification of a novel NTPase from Methanococcus jannaschiiQ27619028
The solution structure of the amino-terminal domain of human DNA polymerase   subunit B is homologous to C-domains of AAA+ proteinsQ27651404
X-ray structure of the complex of regulatory subunits of human DNA polymerase deltaQ27652299
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repairQ27653389
3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerasesQ27655731
Structure and mechanism of human DNA polymerase ηQ27662730
Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primaseQ27663575
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activityQ27931124
The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domainsQ27932484
Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiaeQ27933645
Double-strand break repair in yeast requires both leading and lagging strand DNA polymerasesQ27934176
Increased mutagenesis and unique mutation signature associated with mitotic gene conversionQ27934880
Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolaseQ27935542
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.Q27935769
Unique error signature of the four-subunit yeast DNA polymerase epsilonQ27935855
Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesisQ27936123
Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.Q27936369
Double‐stranded DNA binding properties of Saccharomyces cerevisiae DNA polymerase ɛ and of the Dpb3p‐Dpb4p subassemblyQ27936477
Role of the Putative Zinc Finger Domain of Saccharomyces cerevisiae DNA Polymerase ε in DNA Replication and the S/M Checkpoint PathwayQ27936683
Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.Q27937434
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiaeQ27937483
Thymine-thymine dimer bypass by yeast DNA polymerase zetaQ27938043
Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiaeQ27938074
Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiaeQ27938305
Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathwayQ27938949
Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNAQ27939142
The DNA replication fork in eukaryotic cells.Q27939216
The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunitQ27939620
DNA polymerases alpha, delta, and epsilon localize and function together at replication forks in Saccharomyces cerevisiae.Q27939720
Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiaeQ27940267
Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa geneQ28115300
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase etaQ28115711
A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistanceQ28131606
Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestorsQ30487081
Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alphaQ30897941
The protein components and mechanism of eukaryotic Okazaki fragment maturationQ31034204
Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces cerevisiae.Q31881595
The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conservedQ21144935
hRAD30 mutations in the variant form of xeroderma pigmentosumQ22010237
UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiaeQ22066361
The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζQ24294205
DNA polymerase delta is required for human mismatch repair in vitroQ24313002
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitroQ24319018
Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1Q24319140
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolismQ24337531
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrityQ24337550
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replicationQ24560006
Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase deltaQ24601494
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityQ24606412
Mechanism and evolution of DNA primasesQ24612068
Mutational processes molding the genomes of 21 breast cancersQ24620915
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesQ24630867
Okazaki fragment maturation: nucleases take centre stageQ24632622
Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceQ24645172
Yeast DNA polymerase epsilon participates in leading-strand DNA replicationQ24652913
Polymerase dynamics at the eukaryotic DNA replication forkQ24653831
Structure of the orthorhombic form of human inosine triphosphate pyrophosphataseQ24656288
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeastQ24672450
Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutationsQ24796773
Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27Q24809309
Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeastQ24815602
The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolismQ26851591
The base-alteration spectrum of spontaneous and ultraviolet radiation-induced forward mutations in the URA3 locus of Saccharomyces cerevisiaeQ54374281
Mutants of Saccharomyces cerevisiae supersensitive to the mutagenic effect of 6-N-hydroxylaminopurineQ54423246
Preferential replication-dependent mutagenesis in the lagging DNA strand in Escherichia coliQ54584889
Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coliQ54648245
Greater susceptibility to mutations in lagging strand of DNA replication in Escherichia coli than in leading strandQ54654231
DNA polymerase epsilon - more than a polymeraseQ54948419
The DNA polymerase alpha-primase complex: multiple functions and interactionsQ55109931
A novel family of DNA-polymerase-associated B subunitsQ56902375
A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repairQ64389285
Base sequence alterations induced by ultraviolet radiation in the URA3 locus in yeastQ68897643
Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.Q37140478
Cadmium is a mutagen that acts by inhibiting mismatch repair.Q37142738
Dividing the workload at a eukaryotic replication forkQ37149735
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cellsQ37189455
Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase deltaQ37239015
YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues.Q37339445
The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replicationQ37349653
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.Q37351268
Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites.Q37376606
DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in miceQ37386020
Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemiaQ37388537
Function and biogenesis of iron-sulphur proteinsQ37579052
Chaperoning histones during DNA replication and repairQ37689255
The eukaryotic replicative DNA polymerases take shapeQ37694053
Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerasesQ37764540
ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.Q37769934
Timing and spacing of ubiquitin‐dependent DNA damage bypassQ37878585
Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyondQ37910671
Structure and Function of Eukaryotic DNA Polymerase δQ38037372
Coordination of DNA replication and histone modification by the Rik1-Dos2 complexQ38267644
Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replicationQ38313447
DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical lengthQ38315835
The screening of expression and purification conditions for replicative DNA polymerase associated B-subunits, assignment of the exonuclease activity to the C-terminus of archaeal pol D DP1 subunitQ38324473
Proliferating cell nuclear antigen promotes translesion synthesis by DNA polymerase zetaQ38326585
Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in YeastQ38355096
Flexible tethering of primase and DNA Pol α in the eukaryotic primosome.Q38612714
Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA ReplicationQ38673012
A dynamic polymerase exchange with Escherichia coli DNA polymerase IV replacing DNA polymerase III on the sliding clampQ39262357
Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residuesQ39586073
Mutator phenotype induced by aberrant replicationQ39610863
Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA VariantQ39645960
Functions of base selection step in human DNA polymerase alphaQ39732294
Repair System for Noncanonical Purines in Escherichia coliQ39749064
Errors in DNA replication as a basis of malignant changesQ39870986
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.Q39920642
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2Q28144150
Replication factors required for SV40 DNA replication in vitro. I. DNA structure-specific recognition of a primer-template junction by eukaryotic DNA polymerases and their accessory proteinsQ28241182
Replication factors required for SV40 DNA replication in vitro. II. Switching of DNA polymerase alpha and delta during initiation of leading and lagging strand synthesisQ28241196
A third essential DNA polymerase in S. cerevisiaeQ28241341
Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae.Q28242820
Initiation of chromosomal DNA replication in eukaryotic cells; contribution of yeast genetics to the elucidationQ28249206
Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexesQ28254040
DNA polymerases at the eukaryotic fork-20 years laterQ28255094
DNA mismatch repairQ28256190
Pathway correcting DNA replication errors in Saccharomyces cerevisiaeQ28263175
DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δQ28263318
Flap endonuclease 1: a central component of DNA metabolismQ28266199
Division of labor at the eukaryotic replication forkQ28277921
DNA Polymerase II (ε) of Saccharomyces cerevisiaeDissociates from the DNA Template by Sensing Single-stranded DNAQ28278869
Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary proteinQ28282869
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase deltaQ28289710
The high fidelity and unique error signature of human DNA polymerase epsilonQ28297227
Functions of DNA polymerasesQ28297537
MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesisQ28343030
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zetaQ28354217
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegenerationQ28474016
NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammalsQ28504482
Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancerQ28507505
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreadingQ28510929
Molecular architecture of the mouse DNA polymerase alpha-primase complexQ28513110
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease VQ28585471
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairQ28610858
Temporal order of evolution of DNA replication systems inferred by comparison of cellular and viral DNA polymerasesQ28763890
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian agingQ29616056
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
DNA replication fidelityQ29616841
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and functionQ29617871
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugationQ29619155
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)Q29619959
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase functionQ39965118
Structure of chromatin at deoxyribonucleic acid replication forks: Okazaki fragments released from replicating SV40 chromosomes by single-strand specific endonucleases are not in nucleosomesQ40265161
Metabolism of Okazaki fragments during simian virus 40 DNA replicationQ40267729
Nucleoside and nucleobase analog mutagensQ40395278
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.Q40467165
Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesisQ40525107
Mutagenesis by 8-oxoguanine: an enemy withinQ40849891
Ubiquitin-dependent DNA damage bypass is separable from genome replicationQ41170108
Intrinsic coupling of lagging-strand synthesis to chromatin assembly.Q41457868
Biochemical studies on the mutagen, 6-N-hydroxylaminopurine. Synthesis of the deoxynucleoside triphosphate and its incorporation into DNA in vitroQ41491798
Individual variation of nucleoside triphosphate pyrophosphohydrolase activity in human erythrocytes, granulocytes, lymphocytes, and plateletsQ41531428
Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterizationQ41656356
DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viabilityQ41670559
Purification and characterization of mouse DNA polymerase alpha devoid of primase activityQ41717668
Chromosomal fragmentation is the major consequence of the rdgB defect in Escherichia coliQ41761850
Involvement of the Yeast DNA Polymerase δ in DNA Repair in VivoQ41810177
DNA damage tolerance: when it's OK to make mistakesQ41860261
The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA.Q41868005
3'-->5' exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiaeQ42117167
Quantitative in vitro and in vivo characterization of the human P32T mutant ITPaseQ42174246
Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication forkQ42628317
Oxidation of DNA bases, deoxyribonucleosides and homopolymers by peroxyl radicalsQ42991816
Large-scale expansions of Friedreich's ataxia GAA repeats in yeastQ43077169
An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesisQ43077852
The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP poolQ44025676
Yeast origins establish a strand bias for replicational mutagenesis.Q44084614
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductaseQ44311904
RdgB acts to avoid chromosome fragmentation in Escherichia coliQ44468472
Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challengeQ44502425
Mutagenesis of Benzo[a]pyrene Diol Epoxide in Yeast: Requirement for DNA Polymerase ζ and Involvement of DNA Polymerase ηQ44592450
From context-dependence of mutations to molecular mechanisms of mutagenesisQ44901565
Distribution of ITPA P32T alleles in multiple world populationsQ45025888
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.Q45194375
Trinucleotide expansion in haploid germ cells by gap repairQ45302664
Mispair-, site-, and strand-specific error rates during simian virus 40 origin-dependent replication in vitro with excess deoxythymidine triphosphate.Q45776690
ITPase-deficient mice show growth retardation and die before weaning.Q45981845
Pro32Thr polymorphism of inosine triphosphate pyrophosphatase gene predicts efficacy of low-dose azathioprine for patients with systemic lupus erythematosusQ46171598
Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in miceQ46498840
Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutantsQ46691965
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase deltaQ46848079
Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppressionQ46907603
Effect of Increased Tea Consumption on Oxidative DNA Damage among Smokers: A Randomized Controlled StudyQ47594076
Characterization of the Two Small Subunits of Saccharomyces cerevisiae DNA Polymerase δQ47791987
Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extractsQ47988688
Cdm1, the smallest subunit of DNA polymerase d in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and divisionQ48011513
A unified nomenclature for the subunits of eukaryotic DNA polymerase deltaQ48742451
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancerQ49230797
The genetic activity of N6-hydroxyadenine and 2-amino-N6-hydroxyadenine in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiaeQ50185668
Endonucleolytic function of MutLalpha in human mismatch repairQ50335575
Cleavage of substrates with mismatched nucleotides by Flap endonuclease-1. Implications for mammalian Okazaki fragment processingQ52535059
Analysis of replication intermediates by two-dimensional agarose gel electrophoresisQ52547287
Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sitesQ52563158
The overexpression of specialized DNA polymerases in cancerQ53861866
Mutation in the ITPA gene predicts intolerance to azathioprineQ34372207
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese populationQ34425213
DNA polymerase gamma in mitochondrial DNA replication and repair.Q34492392
CAF-I-dependent control of degradation of the discontinuous strands during mismatch repairQ34582950
Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.Q34586219
Mechanisms of mutagenesis in vivo due to imbalanced dNTP poolsQ34609166
The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiaeQ34616322
Genomic Instability Induced by Mutations in Saccharomyces cerevisiae POL1Q34618433
Phosphoesterase domains associated with DNA polymerases of diverse originsQ34673070
DNA polymerase zeta (pol zeta) in higher eukaryotesQ34729967
Balancing AID and DNA repair during somatic hypermutationQ34966633
Endogenous mutagens and the causes of aging and cancerQ34981086
Origins of spontaneous mutations: specificity and directionality of base-substitution, frameshift, and sequence-substitution mutagenesesQ34995468
Damage-induced localized hypermutability.Q35002361
Oxidative nucleotide damage: consequences and preventionQ35026366
Cellular roles of DNA polymerase zeta and Rev1 proteinQ35037431
A novel function of DNA polymerase zeta regulated by PCNA.Q35040027
The in vitro fidelity of yeast DNA polymerase δ and polymerase ε holoenzymes during dinucleotide microsatellite DNA synthesisQ35064113
DNA repair and trinucleotide repeat instabilityQ35109449
Two modes of FEN1 binding to PCNA regulated by DNA.Q35116227
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iotaQ35131714
Roles of DNA polymerase zeta and Rev1 protein in eukaryotic mutagenesis and translesion replicationQ35132465
Functions of eukaryotic DNA polymerasesQ35170158
Fidelity mechanisms of DNA polymerase betaQ35185683
Mutation Rates across Budding Yeast Chromosome VI Are Correlated with Replication TimingQ35205793
Chromosomal replicases as asymmetric dimers: studies of subunit arrangement and functional consequencesQ35206739
The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA SynthesisQ35311897
Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli.Q35610171
DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicityQ35633543
DNA replication fidelityQ35677447
Reactive nitrogen species in the chemical biology of inflammationQ35677801
DNA damage-induced mutagenesis : a novel target for cancer prevention.Q35679415
Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.Q35728727
Interplay between mismatch repair and chromatin assemblyQ35750965
Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.Q35837411
A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturationQ35874509
Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function.Q35916981
DNA polymerases eta and iotaQ35978843
Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.Q35992079
What a difference a decade makes: insights into translesion DNA synthesisQ36023692
Transcription as a source of genome instabilityQ36036444
DNA polymerase zeta is required for proliferation of normal mammalian cellsQ36044873
DNA polymerases that propagate the eukaryotic DNA replication forkQ36090978
Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instabilityQ36105938
Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛQ36124158
Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζQ36140297
Escherichia coli K-12 mutants in which viability is dependent on recA functionQ36265111
Repeat instability: mechanisms of dynamic mutationsQ36277189
Unequal fidelity of leading strand and lagging strand DNA replication on the Escherichia coli chromosomeQ36283328
Mechanisms of common fragile site instability.Q36294681
The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancerQ36317650
DNA precursor asymmetries, replication fidelity, and variable genome evolutionQ36350924
Escherichia coli mutants deficient in deoxyuridine triphosphataseQ36419435
Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukaryaQ36457110
DNA structures, repeat expansions and human hereditary disorders.Q36483404
DNA precursor metabolism and genomic stabilityQ36525542
DNA polymerases and human diseasesQ36635532
Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.Q36687824
Initiation of simian virus 40 DNA synthesis in vitroQ36690901
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiaeQ36701282
Y-family DNA polymerases and their role in tolerance of cellular DNA damage.Q36778894
HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae.Q36817575
DNA polymerase epsilon: a polymerase of unusual size (and complexity).Q36961060
Pharmacogenetic significance of inosine triphosphataseQ36966047
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activityQ37011650
Mechanism of oxidative DNA damage repair and relevance to human pathologyQ37033569
P433issue9
P304page(s)699-724
P577publication date2012-10-10
P1433published inEnvironmental and Molecular MutagenesisQ15724469
P1476titleModulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools
P478volume53

Reverse relations

cites work (P2860)
Q28652503A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae
Q21203746AID/APOBEC cytosine deaminase induces genome-wide kataegis
Q35590948DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA.
Q64122479Deletion of the DEF1 gene does not confer UV-immutability but frequently leads to self-diploidization in yeast Saccharomyces cerevisiae
Q28547015Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes
Q54478319Dna polymerases and their role in genomic stability
Q28272691Eukaryotic genome instability in light of asymmetric DNA replication
Q28536837Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase
Q88626544Iron-Sulfur Clusters in DNA Polymerases and Primases of Eukaryotes
Q58756653Mutational signature distribution varies with DNA replication timing and strand asymmetry
Q55060101Mutational signatures and mutable motifs in cancer genomes.
Q35677477Optimization of Mutation Pressure in Relation to Properties of Protein-Coding Sequences in Bacterial Genomes
Q33682965Optimization of amino acid replacement costs by mutational pressure in bacterial genomes
Q38870074POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies
Q40533204Polymerase ζ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures.
Q49388555Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.
Q42383457Role of DNA polymerases in repeat-mediated genome instability
Q34070370The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex

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