review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Thomas A Kunkel | |
Peter M Burgers | |||
P2860 | cites work | CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork | Q22065415 |
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication | Q24560006 | ||
Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains | Q24645694 | ||
Yeast DNA polymerase epsilon participates in leading-strand DNA replication | Q24652913 | ||
Structure of the replicating complex of a pol alpha family DNA polymerase | Q27632340 | ||
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase | Q27930849 | ||
The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains | Q27932484 | ||
Eukaryotic DNA polymerases in DNA replication and DNA repair | Q27933940 | ||
Unique error signature of the four-subunit yeast DNA polymerase epsilon | Q27935855 | ||
The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiae | Q27937483 | ||
A third essential DNA polymerase in S. cerevisiae | Q28241341 | ||
Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae. | Q28242820 | ||
Reconstitution of complete SV40 DNA replication with purified replication factors | Q28251397 | ||
Pathway correcting DNA replication errors in Saccharomyces cerevisiae | Q28263175 | ||
Division of labor at the eukaryotic replication fork | Q28277921 | ||
Functions of DNA polymerases | Q28297537 | ||
DNA replication fidelity | Q29616841 | ||
RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta. | Q33255508 | ||
Discrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation | Q34008591 | ||
Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase | Q34104931 | ||
Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta. | Q35728727 | ||
Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon. | Q35837411 | ||
DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication. | Q35849678 | ||
DNA polymerase epsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts | Q35859369 | ||
DNA polymerases that propagate the eukaryotic DNA replication fork | Q36090978 | ||
DNA polymerase epsilon: a polymerase of unusual size (and complexity). | Q36961060 | ||
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity | Q37011650 | ||
Exonuclease-polymerase active site partitioning of primer-template DNA strands and equilibrium Mg2+ binding properties of bacteriophage T4 DNA polymerase | Q38335506 | ||
Using 2-aminopurine fluorescence to measure incorporation of incorrect nucleotides by wild type and mutant bacteriophage T4 DNA polymerases | Q38363604 | ||
Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint control | Q39459799 | ||
DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability | Q41670559 | ||
Analysis of the essential functions of the C-terminal protein/protein interaction domain of Saccharomyces cerevisiae pol epsilon and its unexpected ability to support growth in the absence of the DNA polymerase domain | Q41682738 | ||
3'-->5' exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiae | Q42117167 | ||
Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication fork | Q42628317 | ||
Yeast origins establish a strand bias for replicational mutagenesis. | Q44084614 | ||
Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions. | Q46554910 | ||
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta | Q46848079 | ||
Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts | Q47988688 | ||
Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases. | Q54639795 | ||
The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae | Q72240900 | ||
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) | Q77896965 | ||
The Saccharomyces cerevisiae protein YJR043C (Pol32) interacts with the catalytic subunit of DNA polymerase alpha and is required for cell cycle progression in G2/M | Q77937435 | ||
The Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) Binding | Q79241756 | ||
Fidelity of DNA polymerase delta holoenzyme from Saccharomyces cerevisiae: the sliding clamp proliferating cell nuclear antigen decreases its fidelity | Q79326276 | ||
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta | Q82346662 | ||
P433 | issue | 11 | |
P304 | page(s) | 521-527 | |
P577 | publication date | 2008-09-27 | |
P1433 | published in | Trends in Cell Biology | Q1573994 |
P1476 | title | Dividing the workload at a eukaryotic replication fork | |
P478 | volume | 18 |
Q34236588 | A Specific Docking Site for DNA Polymerase α-Primase on the SV40 Helicase Is Required for Viral Primosome Activity, but Helicase Activity Is Dispensable |
Q27935272 | A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. |
Q36035517 | A non-natural nucleoside with combined therapeutic and diagnostic activities against leukemia |
Q28295980 | A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase |
Q28652503 | A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae |
Q28082955 | A proposal: Evolution of PCNA's role as a marker of newly replicated DNA |
Q37467362 | A trimeric DNA polymerase complex increases the native replication processivity |
Q35874528 | ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis |
Q33740206 | Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases |
Q28273538 | Age-dependent down-regulation of DNA polymerase δ1 in human lymphocytes |
Q27024636 | Antimutator variants of DNA polymerases |
Q36833039 | Archaeal DNA polymerase D but not DNA polymerase B is required for genome replication in Thermococcus kodakarensis |
Q34862043 | Archaeology of eukaryotic DNA replication |
Q35791501 | Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target |
Q50233460 | Architecture of the Saccharomyces cerevisiae Replisome |
Q57754548 | Bacterial and Eukaryotic Replisome Machines |
Q35291466 | Balancing eukaryotic replication asymmetry with replication fidelity. |
Q38026112 | Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer |
Q24622552 | CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast |
Q34314240 | Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the MultiBac system |
Q47650967 | Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress |
Q51003935 | Chromatin Constrains the Initiation and Elongation of DNA Replication. |
Q24611034 | Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing |
Q33799163 | Continued primer synthesis at stalled replication forks contributes to checkpoint activation. |
Q37781559 | Cyclin-dependent kinase-dependent initiation of chromosomal DNA replication |
Q36884849 | DNA Mismatch Repair Interacts with CAF-1- and ASF1A-H3-H4-dependent Histone (H3-H4)2 Tetramer Deposition |
Q38855041 | DNA Polymerases Divide the Labor of Genome Replication. |
Q37386020 | DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice |
Q28263318 | DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ |
Q34520026 | DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis |
Q28255094 | DNA polymerases at the eukaryotic fork-20 years later |
Q38227870 | DNA polymerases drive DNA sequencing-by-synthesis technologies: both past and present |
Q37416977 | DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures |
Q28295863 | DNA replication fidelity and cancer |
Q90047387 | Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism |
Q38572102 | Deoxyribonucleotide metabolism, mutagenesis and cancer |
Q34396924 | Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta} |
Q27679146 | Distinct Structural Alterations in Proliferating Cell Nuclear Antigen Block DNA Mismatch Repair |
Q36020875 | Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening |
Q33596465 | Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase in the presence of replication protein A and proliferating-cell nuclear antigen |
Q36643853 | Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast |
Q34274334 | Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. |
Q34950028 | Epigenetic inheritance during the cell cycle |
Q27011365 | Eukaryotic DNA polymerase ζ |
Q33711830 | Eukaryotic Mismatch Repair in Relation to DNA Replication |
Q30487081 | Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors |
Q38829896 | Evolution of replication machines |
Q28245481 | Evolution of replicative DNA polymerases in archaea and their contributions to the eukaryotic replication machinery |
Q36772885 | Evolving views of DNA replication (in)fidelity |
Q36553485 | Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase α |
Q35497978 | Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells |
Q56637826 | Fidelity of DNA replication—a matter of proofreading |
Q47987433 | Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis |
Q41074421 | Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis |
Q33494212 | Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis |
Q33603305 | Functions of alternative replication protein A in initiation and elongation |
Q38967736 | G-quadruplex-induced instability during leading-strand replication |
Q35141820 | Gap-directed translesion DNA synthesis of an abasic site on circular DNA templates by a human replication complex. |
Q33694435 | Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae |
Q39843802 | Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters |
Q33704744 | Genome-wide model for the normal eukaryotic DNA replication fork. |
Q47647485 | Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours. |
Q34439328 | Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition. |
Q37414576 | High fidelity and lesion bypass capability of human DNA polymerase delta |
Q51349387 | Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6. |
Q36466634 | Human DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides |
Q37612640 | Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass |
Q38781896 | Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand |
Q38421370 | In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta |
Q47137568 | Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer |
Q34480026 | Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry |
Q36982834 | Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis |
Q47135454 | Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae. |
Q38303938 | Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine |
Q37385017 | Kinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ε. |
Q39273323 | Linking the DNA strand asymmetry to the spatio-temporal replication program. I. About the role of the replication fork polarity in genome evolution |
Q33633542 | Long-range bidirectional strand asymmetries originate at CpG islands in the human genome |
Q93334575 | Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors |
Q35786677 | Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. |
Q34446700 | Mismatch repair balances leading and lagging strand DNA replication fidelity. |
Q27937434 | Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε. |
Q37483304 | Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools |
Q38045848 | Mouse models of DNA polymerases. |
Q36255286 | Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint |
Q34919969 | Mutator phenotypes due to DNA replication infidelity. |
Q24632622 | Okazaki fragment maturation: nucleases take centre stage |
Q34071783 | P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA. |
Q64231032 | PCNA accelerates the nucleotide incorporation rate by DNA polymerase δ |
Q36794575 | PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ. |
Q37396845 | PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2. |
Q28272658 | PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ |
Q54351302 | POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium. |
Q27656496 | Physical Interactions between Mcm10, DNA, and DNA Polymerase |
Q33482605 | Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway |
Q90384164 | Plant DNA Polymerases |
Q35007615 | Polymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing |
Q28268105 | Polymerase δ replicates both strands after homologous recombination-dependent fork restart |
Q34139948 | Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase delta |
Q33731381 | Processing ribonucleotides incorporated during eukaryotic DNA replication. |
Q33756104 | Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis |
Q36941096 | Proficient Replication of the Yeast Genome by a Viral DNA Polymerase |
Q37612555 | Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork |
Q35550942 | Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. |
Q37289734 | Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases |
Q38120365 | Regulating DNA replication in eukarya |
Q38050704 | Regulation of human DNA polymerase delta in the cellular responses to DNA damage |
Q35138067 | Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases |
Q39582800 | Replication-associated mutational asymmetry in the human genome |
Q26825747 | Replicative DNA polymerase mutations in cancer |
Q28258327 | Replicative DNA polymerase δ but not ε proofreads errors in Cis and in Trans |
Q36865161 | Replicative DNA polymerases |
Q37450024 | Replisome structure and conformational dynamics underlie fork progression past obstacles |
Q30047225 | Ribonucleotides in DNA: Origins, repair and consequences |
Q42383457 | Role of DNA polymerases in repeat-mediated genome instability |
Q47616387 | Signal-on electrochemical assay for label-free detection of TdT and BamHI activity based on grown DNA nanowire-templated copper nanoclusters. |
Q46596091 | Single-Molecule DNA Polymerase Dynamics at a Bacterial Replisome in Live Cells. |
Q34488524 | Single-molecule studies of DNA replisome function |
Q35814999 | Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication |
Q28285350 | SnapShot: The replisome |
Q34339095 | Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage |
Q27681178 | Structural Basis for the Interaction of a Hexameric Replicative Helicase with the Regulatory Subunit of Human DNA Polymerase -Primase |
Q26829680 | Structural insights into eukaryotic DNA replication |
Q27660253 | Structure of a DNA Polymerase -Primase Domain That Docks on the SV40 Helicase and Activates the Viral Primosome |
Q27679118 | Structure of monoubiquitinated PCNA: implications for DNA polymerase switching and Okazaki fragment maturation |
Q38259475 | Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated |
Q34070370 | The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex |
Q34433261 | The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability |
Q28551589 | The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis |
Q26752772 | The Eukaryotic Replisome Goes Under the Microscope |
Q64388793 | The Largest Subunit of DNA Polymerase Delta Is Required for Normal Formation of Meiotic Type I Crossovers |
Q37595175 | The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation. |
Q36216306 | The Werner syndrome protein promotes CAG/CTG repeat stability by resolving large (CAG)(n)/(CTG)(n) hairpins |
Q27310198 | The architecture of a eukaryotic replisome. |
Q37028396 | The eukaryotic CMG helicase pumpjack and integration into the replisome |
Q27027501 | The hidden side of unstable DNA repeats: Mutagenesis at a distance |
Q28297227 | The high fidelity and unique error signature of human DNA polymerase epsilon |
Q38263955 | The histone chaperone facilitates chromatin transcription (FACT) protein maintains normal replication fork rates |
Q47384276 | The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon |
Q43222863 | The importance of being DNA. |
Q21144935 | The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved |
Q33814597 | The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis |
Q38985016 | The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery |
Q42467404 | The role of DNA polymerase alpha in the control of mutagenesis in Saccharomyces cerevisiae cells starved for nutrients |
Q28303222 | The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression |
Q37861006 | Ubiquitination of PCNA and its essential role in eukaryotic translesion synthesis |
Q27005670 | Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases |
Q36842394 | Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions |
Q47338511 | Visualizing bacterial DNA replication and repair with molecular resolution. |
Q33570555 | What influences DNA replication rate in budding yeast? |
Q34154198 | Whither the replisome: emerging perspectives on the dynamic nature of the DNA replication machinery |
Q28273483 | Who Is Leading the Replication Fork, Pol ε or Pol δ? |
Q47148057 | Whole Genome Sequence Analysis of Mutations Accumulated in rad27Δ Yeast Strains with Defects in the Processing of Okazaki Fragments Indicates Template-Switching Events |
Q41652726 | Yeast DNA polymerase ϵ catalytic core and holoenzyme have comparable catalytic rates |
Q37239015 | Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase delta |
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