DNA polymerases at the eukaryotic fork-20 years later

scientific article

DNA polymerases at the eukaryotic fork-20 years later is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.MRFMMM.2009.08.002
P932PMC publication ID2822129
P698PubMed publication ID19682465
P5875ResearchGate publication ID26743673

P2093author name stringYouri I Pavlov
Polina V Shcherbakova
P2860cites workThe Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) BindingQ79241756
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase deltaQ82346662
CELLULAR DNA REPLICASES: Components and Dynamics at the Replication ForkQ22065415
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitroQ24319018
Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeastQ24554269
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replicationQ24560006
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityQ24606412
Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceQ24645172
Yeast DNA polymerase epsilon participates in leading-strand DNA replicationQ24652913
Polymerase dynamics at the eukaryotic DNA replication forkQ24653831
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeastQ24672450
Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutationsQ24796773
Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27Q24809309
X-ray structure of the complex of regulatory subunits of human DNA polymerase deltaQ27652299
3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerasesQ27655731
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phaseQ27930849
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activityQ27931124
The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replicationQ27933493
Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiaeQ27933645
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.Q27935769
Double‐stranded DNA binding properties of Saccharomyces cerevisiae DNA polymerase ɛ and of the Dpb3p‐Dpb4p subassemblyQ27936477
Role of the putative zinc finger domain of Saccharomyces cerevisiae DNA polymerase epsilon in DNA replication and the S/M checkpoint pathwayQ27936683
The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiaeQ27937483
Thymine-thymine dimer bypass by yeast DNA polymerase zetaQ27938043
Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiaeQ27938074
Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiaeQ27938305
The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunitQ27939620
DNA polymerases alpha, delta, and epsilon localize and function together at replication forks in Saccharomyces cerevisiae.Q27939720
Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiaeQ27940267
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2Q28144150
A third essential DNA polymerase in S. cerevisiaeQ28241341
Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae.Q28242820
Pathway correcting DNA replication errors in Saccharomyces cerevisiaeQ28263175
Division of labor at the eukaryotic replication forkQ28277921
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase deltaQ28289710
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zetaQ28354217
Temporal order of evolution of DNA replication systems inferred by comparison of cellular and viral DNA polymerasesQ28763890
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and functionQ29617871
Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestorsQ30487081
Two essential DNA polymerases at the bacterial replication fork.Q33183142
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.Q33300908
DNA polymerases alpha, delta, and epsilon: three distinct enzymes from HeLa cellsQ33765421
Evidence for extrinsic exonucleolytic proofreading.Q34010452
hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsQ34161894
Discontinuous DNA replicationQ34251800
Dynamic protein interactions in the bacteriophage T4 replisome.Q34365405
Phosphoesterase domains associated with DNA polymerases of diverse originsQ34673070
DNA polymerase zeta (pol zeta) in higher eukaryotesQ34729967
Cellular roles of DNA polymerase zeta and Rev1 proteinQ35037431
A novel function of DNA polymerase zeta regulated by PCNA.Q35040027
Two modes of FEN1 binding to PCNA regulated by DNA.Q35116227
Chromosomal replicases as asymmetric dimers: studies of subunit arrangement and functional consequencesQ35206739
Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.Q35728727
A novel family of DNA-polymerase-associated B subunitsQ56902375
Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerasesQ71239708
The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiaeQ72240900
POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathwayQ73319794
Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.Q35837411
DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication.Q35849678
DNA polymerases that propagate the eukaryotic DNA replication forkQ36090978
Discontinuous or semi-discontinuous DNA replication in Escherichia coli?Q36126246
Mutator alleles of yeast DNA polymerase zeta.Q36247787
Unequal fidelity of leading strand and lagging strand DNA replication on the Escherichia coli chromosomeQ36283328
Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukaryaQ36457110
Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.Q36687824
DNA polymerase epsilon: a polymerase of unusual size (and complexity).Q36961060
Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesisQ36990200
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activityQ37011650
Dividing the workload at a eukaryotic replication forkQ37149735
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repairQ37181822
Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta.Q37235387
Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase deltaQ37239015
The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replicationQ37349653
PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.Q37482417
Enzymatic switching for efficient and accurate translesion DNA replication.Q37509255
Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activitiesQ38289146
The screening of expression and purification conditions for replicative DNA polymerase associated B-subunits, assignment of the exonuclease activity to the C-terminus of archaeal pol D DP1 subunitQ38324473
Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in YeastQ38355096
Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint controlQ39459799
Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterizationQ41656356
DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viabilityQ41670559
Analysis of the essential functions of the C-terminal protein/protein interaction domain of Saccharomyces cerevisiae pol epsilon and its unexpected ability to support growth in the absence of the DNA polymerase domainQ41682738
Purification and characterization of mouse DNA polymerase alpha devoid of primase activityQ41717668
DNA polymerases at the replication fork in eukaryotesQ41909494
GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeastQ42088381
3'-->5' exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiaeQ42117167
Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication forkQ42628317
An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesisQ43077852
The replisome uses mRNA as a primer after colliding with RNA polymeraseQ43225835
Yeast origins establish a strand bias for replicational mutagenesis.Q44084614
Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutantsQ46691965
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase deltaQ46848079
Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase deltaQ47791987
Cdm1, the smallest subunit of DNA polymerase d in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and divisionQ48011513
A unified nomenclature for the subunits of eukaryotic DNA polymerase deltaQ48742451
Characterization of a triple DNA polymerase replisome.Q54436034
Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases.Q54639795
DNA polymerase epsilon - more than a polymerase.Q54948419
The DNA polymerase alpha-primase complex: multiple functions and interactions.Q55109931
P433issue1-2
P407language of work or nameEnglishQ1860
P304page(s)45-53
P577publication date2010-03-01
P1433published inMutation ResearchQ6943732
P1476titleDNA polymerases at the eukaryotic fork-20 years later
P478volume685

Reverse relations

cites work (P2860)
Q46223626A Modified Family‐B Archaeal DNA Polymerase with Reverse Transcriptase Activity
Q33591410A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability
Q28652503A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae
Q28272700A panoply of errors: polymerase proofreading domain mutations in cancer
Q61124737A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
Q53836474Activity and fidelity of human DNA polymerase α depend on primer structure.
Q34397069An end for mismatch repair
Q35291466Balancing eukaryotic replication asymmetry with replication fidelity.
Q35860754Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit
Q38287657Crystal structure of the human Polϵ B-subunit in complex with the C-terminal domain of the catalytic subunit.
Q36884849DNA Mismatch Repair Interacts with CAF-1- and ASF1A-H3-H4-dependent Histone (H3-H4)2 Tetramer Deposition
Q38855041DNA Polymerases Divide the Labor of Genome Replication.
Q26991961DNA polymerase delta in DNA replication and genome maintenance
Q28263318DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ
Q89983002DNA polymerase δ proofreads errors made by DNA polymerase ε
Q26822699DNA polymerase ε and its roles in genome stability
Q37416977DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures
Q37029887Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction
Q37303021Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.
Q37676238Elaborated Action of the Human Primosome
Q36643853Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast
Q33711830Eukaryotic Mismatch Repair in Relation to DNA Replication
Q28245481Evolution of replicative DNA polymerases in archaea and their contributions to the eukaryotic replication machinery
Q33704744Genome-wide model for the normal eukaryotic DNA replication fork.
Q28536837Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase
Q34363341In vivo bypass of 8-oxodG.
Q88626544Iron-Sulfur Clusters in DNA Polymerases and Primases of Eukaryotes
Q34446700Mismatch repair balances leading and lagging strand DNA replication fidelity.
Q27937434Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.
Q37483304Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools
Q38045848Mouse models of DNA polymerases.
Q36540667Non-canonical actions of mismatch repair
Q36835707PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase δ, η, and ζ activities.
Q38870074POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies
Q92009964POLE proofreading defects: Contributions to mutagenesis and cancer
Q35184879Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli
Q53062576Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast.
Q38050704Regulation of human DNA polymerase delta in the cellular responses to DNA damage
Q35138067Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases
Q39421725Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy
Q28258327Replicative DNA polymerase δ but not ε proofreads errors in Cis and in Trans
Q37628288Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity
Q42383457Role of DNA polymerases in repeat-mediated genome instability
Q36286104Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cells
Q34711991Structural basis for inhibition of DNA replication by aphidicolin
Q26829680Structural insights into eukaryotic DNA replication
Q34070370The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex
Q34433261The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability
Q47755642The CysB motif of Rev3p involved in the formation of the four-subunit DNA polymerase ζ is required for defective-replisome-induced mutagenesis
Q92857979The Mutator Phenotype: Adapting Microbial Evolution to Cancer Biology
Q27027501The hidden side of unstable DNA repeats: Mutagenesis at a distance
Q28297227The high fidelity and unique error signature of human DNA polymerase epsilon
Q47391938The importance of an interaction network for proper DNA polymerase ζ heterotetramer activity.
Q21144935The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved
Q42467404The role of DNA polymerase alpha in the control of mutagenesis in Saccharomyces cerevisiae cells starved for nutrients
Q28303222The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression
Q34391109Transformation with oligonucleotides creating clustered changes in the yeast genome
Q35600360Volatility of Mutator Phenotypes at Single Cell Resolution

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