A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta

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A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M610356200
P698PubMed publication ID17317665

P2093author name stringErnest Y C Lee
Marietta Y W T Lee
Sufang Zhang
Xiao Meng
Yajing Zhou
Sandra Trusa
P2860cites workIsolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extractsQ22009456
Identification of a fourth subunit of mammalian DNA polymerase deltaQ22253483
Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase deltaQ24292690
p53: traffic cop at the crossroads of DNA repair and recombinationQ36028209
DNA polymerases that propagate the eukaryotic DNA replication forkQ36090978
DNA replication and progression through S phaseQ36101749
DNA damage responses and their many interactions with the replication forkQ36402069
p53 in recombination and repairQ36423948
Translesion synthesis in mammalian cellsQ36541050
The ATM-dependent DNA damage signaling pathwayQ36547714
Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase.Q36592000
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathwayQ36648425
Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint controlQ39459799
Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigenQ40301471
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damageQ40494337
Lactacystin, proteasome function, and cell fateQ41043791
DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viabilityQ41670559
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in XenopusQ41846285
Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrestQ44672483
Visualization of altered replication dynamics after DNA damage in human cellsQ44776027
Is this protein ubiquitinated?Q45226540
Chemical and genetic strategies for manipulating polyubiquitin chain structureQ46843251
Checkpoint regulation of replication dynamics in UV-irradiated human cells.Q53599798
Distinctive activities of DNA polymerases during human DNA replicationQ24292826
Functional roles of p12, the fourth subunit of human DNA polymerase deltaQ24306171
Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzymeQ24313771
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitroQ24319018
SUMO-1 modification activates the transcriptional response of p53Q24529948
Recognition of the polyubiquitin proteolytic signalQ24530006
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Q24550952
Werner protein recruits DNA polymerase delta to the nucleolusQ24674594
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
The ubiquitin systemQ27860803
Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigenQ28202593
Reconstitution of human DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzymeQ28205766
ATR and ATRIP: partners in checkpoint signalingQ28207471
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I moleculesQ28248180
Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cellsQ28261710
A new mammalian DNA polymerase with 3' to 5' exonuclease activity: DNA polymerase deltaQ28264141
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpointsQ28266170
Further studies on calf thymus DNA polymerase delta purified to homogeneity by a new procedureQ28268211
Mechanism and function of deubiquitinating enzymesQ28295758
FGF2-induced upregulation of DNA polymerase-delta p12 subunit in endothelial cellsQ28589436
Proteasomes and their kin: proteases in the machine ageQ29614359
Right place, right time, and only once: replication initiation in metazoansQ30438278
Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.Q30878888
Viral transport of DNA damage that mimics a stalled replication forkQ31135876
The DNA polymerase activity of Pol epsilon holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extractsQ33254833
Caffeine and human DNA metabolism: the magic and the mysteryQ33715255
The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteinsQ33999031
Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phaseQ34104931
DNA damage-induced apoptosisQ34312499
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damageQ34443534
The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanismQ34557750
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)15330-40
P577publication date2007-05-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleA novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
P478volume282

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cites work (P2860)
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