Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.

scientific article published on January 2006

Roles of DNA polymerases in replication, repair, and recombination in eukaryotes. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0074-7696(06)55002-8
P698PubMed publication ID17178465
P5875ResearchGate publication ID6622651

P50authorIgor B. RogozinQ45324573
P2093author name stringYouri I Pavlov
Polina V Shcherbakova
P2860cites workThe COG database: an updated version includes eukaryotesQ21284294
Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymeraseQ22010228
hRAD30 mutations in the variant form of xeroderma pigmentosumQ22010237
The human REV1 gene codes for a DNA template-dependent dCMP transferaseQ22010721
Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilonQ22010787
Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinBQ22011012
CELLULAR DNA REPLICASES: Components and Dynamics at the Replication ForkQ22065415
Eukaryotic DNA PolymerasesQ22065416
UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiaeQ22066361
Functional human mitochondrial DNA polymerase gamma forms a heterotrimerQ24293340
Aphidicolin-resistant and -sensitive base excision repair in wild-type and DNA polymerase beta-defective mouse cellsQ24294984
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cellsQ24298399
POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308Q24304200
Multiple roles of vertebrate REV genes in DNA repair and recombinationQ24306340
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationQ28208979
Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cellsQ28209176
Thymine DNA glycosylaseQ28216069
Error rate and specificity of human and murine DNA polymerase etaQ28216092
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomasQ28217205
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblastsQ28238256
A third essential DNA polymerase in S. cerevisiaeQ28241341
Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae.Q28242820
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolismQ28245231
DNA mismatch repairQ28256190
Pathway correcting DNA replication errors in Saccharomyces cerevisiaeQ28263175
Flap endonuclease 1: a central component of DNA metabolismQ28266199
Interaction of hREV1 with three human Y-family DNA polymerasesQ28266239
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complexQ28267285
Mutual interactions between the SUMO and ubiquitin systems: a plea of no contestQ28269305
Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repairQ28270934
Rev1 employs a novel mechanism of DNA synthesis using a protein templateQ28274770
DNA polymerase II (epsilon) of Saccharomyces cerevisiae dissociates from the DNA template by sensing single-stranded DNAQ28278869
Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl proteinQ28283240
Formation and repair of interstrand cross-links in DNAQ28296085
Functions of DNA polymerasesQ28297537
MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesisQ28343030
Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNAQ28360244
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genesQ28506592
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damageQ28507940
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreadingQ28510929
Molecular architecture of the mouse DNA polymerase alpha-primase complexQ28513110
DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosisQ28586606
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with AtmQ28586941
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutationQ28587504
Quality control by DNA repairQ28608962
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairQ28610858
Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitroQ28646677
DNA polymerase delta is required for human mismatch repair in vitroQ24313002
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitroQ24319018
A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zetaQ24323043
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).Q24532243
Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer terminiQ24534772
Mutations in human DNA polymerase eta motif II alter bypass of DNA lesionsQ24536098
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationQ24537096
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.Q24537135
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.Q24537708
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repairQ24540101
Physical and functional interactions of human DNA polymerase eta with PCNAQ24548300
The ring-type polymerase sliding clamp familyQ24551008
Replicative DNA polymerasesQ24551009
Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeastQ24554269
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replicationQ24560006
High-efficiency bypass of DNA damage by human DNA polymerase QQ24561381
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitinationQ24563236
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesisQ24594244
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityQ24606412
Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosusQ24644860
A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repairQ24646838
Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletionsQ24670499
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeastQ24672450
The human DINB1 gene encodes the DNA polymerase PolthetaQ24683573
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesisQ24794355
Algorithms for computing parsimonious evolutionary scenarios for genome evolution, the last universal common ancestor and dominance of horizontal gene transfer in the evolution of prokaryotesQ24797719
Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27Q24809309
A network of multi-tasking proteins at the DNA replication fork preserves genome stabilityQ24814638
Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe.Q24816438
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacteriumQ25257835
Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7Q27624999
Structure of the replicating complex of a pol alpha family DNA polymeraseQ27632340
Dynamic protein interactions in the bacteriophage T4 replisome.Q34365405
Enzymology of mitochondrial base excision repairQ34367235
Base excision repair in nuclear and mitochondrial DNA.Q34367251
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29.Q34368233
Repair and genetic consequences of endogenous DNA base damage in mammalian cellsQ34371854
Opening of the clamp: an intimate view of an ATP-driven biological machine.Q34381828
Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyreneQ34387678
A novel DNA polymerase family found in ArchaeaQ34465210
DNA polymerase gamma in mitochondrial DNA replication and repair.Q34492392
Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation.Q34492397
The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cellsQ34498295
Dynamics of DNA replication factories in living cellsQ34508274
Molecular mechanism of class switch recombination: linkage with somatic hypermutationQ34542246
Mechanism of DNA double-strand break repair by non-homologous end joiningQ34557861
The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimerQ34570808
Interplay between replication and recombination in Escherichia coli: impact of the alternative DNA polymerasesQ34574827
DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damageQ34587534
Specialized DNA polymerases, cellular survival, and the genesis of mutationsQ34662609
V(D)J recombination: RAG proteins, repair factors, and regulationQ34667417
Phosphoesterase domains associated with DNA polymerases of diverse originsQ34673070
GINS, a central nexus in the archaeal DNA replication forkQ34683040
Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affairQ34770150
The spindle checkpoint: structural insights into dynamic signallingQ34931754
Telomerase: biochemical considerations for enzyme and substrate.Q34989394
The yeast Saccharomyces cerevisiae DNA polymerase IV: possible involvement in double strand break DNA repairQ35009312
Cellular roles of DNA polymerase zeta and Rev1 proteinQ35037431
A novel function of DNA polymerase zeta regulated by PCNA.Q35040027
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.Q35047056
DNA repair and trinucleotide repeat instabilityQ35109449
A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genesQ35114235
Two modes of FEN1 binding to PCNA regulated by DNA.Q35116227
DNA building blocks at the foundation of better survival.Q35122663
Structural Insights into the Origins of DNA Polymerase FidelityQ35123987
Streisinger revisited: DNA synthesis errors mediated by substrate misalignmentsQ35132473
DNA replication: a complex matter.Q35166875
Initiation of simian virus 40 DNA synthesis in vitroQ36690901
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiaeQ36701282
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activityQ37011650
Properties of DNA polymerases delta and epsilon, and their roles in eukaryotic DNA replicationQ37157748
A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational designQ37236371
The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replicationQ37349653
Enzymatic switching for efficient and accurate translesion DNA replication.Q37509255
Mutagenesis during in vitro DNA synthesisQ37584287
Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiaeQ37731934
DNA polymerase delta: a second eukaryotic DNA replicaseQ37940936
Eukaryotic DNA polymerases alpha and delta: conserved properties and interactions, from yeast to mammalian cellsQ38232931
Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activitiesQ38289146
Yeast Rev1 protein is a G template-specific DNA polymeraseQ38291977
Fidelity of eucaryotic DNA polymerase delta holoenzyme from Schizosaccharomyces pombeQ38313569
DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zetaQ38315759
Mismatch tolerance by DNA polymerase Pol4 in the course of nonhomologous end joining in Saccharomyces cerevisiae.Q38316253
The screening of expression and purification conditions for replicative DNA polymerase associated B-subunits, assignment of the exonuclease activity to the C-terminus of archaeal pol D DP1 subunitQ38324473
Proliferating cell nuclear antigen promotes translesion synthesis by DNA polymerase zetaQ38326585
A biochemically defined system for mammalian nonhomologous DNA end joiningQ38333666
Effect of accessory proteins on T4 DNA polymerase replication fidelityQ38337375
DNA polymerase beta: structure-fidelity relationship from Pre-steady-state kinetic analyses of all possible correct and incorrect base pairs for wild type and R283A mutantQ38348534
Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in YeastQ38355096
Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.Q38362195
Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluoreneQ39095697
Base substitution mutagenesis by terminal transferase: its role in somatic mutagenesisQ39103802
Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repairQ39449001
Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiaeQ39452783
Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iotaQ39455619
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cellsQ39456389
Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproductsQ39468393
Highly frequent frameshift DNA synthesis by human DNA polymerase muQ39529040
Interactions between deoxyribonucleotide and DNA synthesisQ39532113
Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesionsQ39719605
A neutralizing antibody against human DNA polymerase epsilon inhibits cellular but not SV40 DNA replicationQ39729133
Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.Q39744882
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesisQ27634744
Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replicationQ27635332
Replication of a cis-syn thymine dimer at atomic resolutionQ27641791
Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTPQ27729369
Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanismQ27729370
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69Q27740210
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanismQ27742804
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolutionQ27748814
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
A genomic perspective on protein familiesQ27860913
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joiningQ27919680
Trf4 and Trf5 proteins of Saccharomyces cerevisiae exhibit poly(A) RNA polymerase activity but no DNA polymerase activityQ27930373
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activityQ27931124
Deoxycytidyl transferase activity of yeast REV1 proteinQ27931173
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.Q27931975
The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domainsQ27932484
ATR homolog Mec1 controls association of DNA polymerase zeta-Rev1 complex with regions near a double-strand breakQ27932718
Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiaeQ27933125
Double-strand break repair in yeast requires both leading and lagging strand DNA polymerasesQ27934176
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.Q27934276
The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesisQ27934540
Yeast Trf5p is a nuclear poly(A) polymeraseQ27935421
A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joiningQ27935436
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, PoletaQ27935465
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.Q27935769
Unique error signature of the four-subunit yeast DNA polymerase epsilonQ27935855
Double‐stranded DNA binding properties of Saccharomyces cerevisiae DNA polymerase ɛ and of the Dpb3p‐Dpb4p subassemblyQ27936477
Role of the putative zinc finger domain of Saccharomyces cerevisiae DNA polymerase epsilon in DNA replication and the S/M checkpoint pathwayQ27936683
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiaeQ27937483
Thymine-thymine dimer bypass by yeast DNA polymerase zetaQ27938043
Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathwayQ27938668
Accessibility of DNA polymerases to repair synthesis during nucleotide excision repair in yeast cell-free extractsQ27938785
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damageQ28646728
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian agingQ29616056
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanismQ29616775
DNA replication fidelityQ29616841
Distinguishing Homologous from Analogous ProteinsQ29617777
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and functionQ29617871
DNA excision repairQ29618453
A mechanism for all polymerasesQ29618812
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugationQ29619155
DNA polymerases: structural diversity and common mechanismsQ29619403
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesisQ29619757
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
Proliferating cell nuclear antigen (PCNA): a dancer with many partnersQ29620131
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpointQ29620700
Pol kappa: A DNA polymerase required for sister chromatid cohesion.Q30305921
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitroQ30431649
Telomerase and chromosome end maintenance.Q30472155
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymeraseQ30535279
DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary historyQ30559537
Molecular mechanism of nucleotide excision repair.Q30669716
A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysisQ30669971
Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.Q30769976
Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unrelated to any known DNA polymerasesQ30917224
A novel PCNA-binding motif identified by the panning of a random peptide display libraryQ30985158
Recent progress in the biology, chemistry and structural biology of DNA glycosylasesQ32063493
Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered processQ33198930
Reconstitution of 5'-directed human mismatch repair in a purified systemQ33222844
Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alphaQ33228026
The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.Q33257520
Fidelity of a human cell DNA replication complexQ33650264
The distribution of rates of spontaneous mutation over viruses, prokaryotes, and eukaryotesQ33692274
Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1pQ33770262
Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymeraseQ33792439
Sliding clamps: a (tail)ored fit.Q33830292
DNA double strand break repair in mammalian cellsQ33885081
Genome-wide somatic hypermutationQ33905110
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitroQ33938237
Functions of eukaryotic DNA polymerasesQ35170158
Fidelity mechanisms of DNA polymerase betaQ35185683
Chromosomal replicases as asymmetric dimers: studies of subunit arrangement and functional consequencesQ35206739
Roles of Saccharomyces cerevisiae DNA polymerases Poleta and Polzeta in response to irradiation by simulated sunlightQ35221964
Mending the Break: Two DNA Double-Strand Break Repair Machines in EukaryotesQ35543795
RecA-Dependent Recovery of Arrested DNA Replication ForksQ35583008
Repair of abasic sites in DNA.Q35592868
Checkpoint responses to replication stalling: inducing tolerance and preventing mutagenesisQ35595521
Effects of Escherichia coli dnaE antimutator alleles in a proofreading-deficient mutD5 strain.Q35596950
Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiaeQ35617303
DNA replication fidelityQ35677447
Structural mechanisms of DNA replication, repair, and recombinationQ35748285
DNA polymerase gamma, the mitochondrial replicaseQ35799966
RNA polymerase II structure: from core to functional complexesQ35804643
The PCNA-RFC families of DNA clamps and clamp loadersQ35813300
Regulation of the DNA replication fork: a way to fight genomic instabilityQ35858504
Estrogen metabolites, conjugates, and DNA adducts: possible biomarkers for risk of breast, prostate, and other human cancersQ35936635
DNA polymerase fidelity: kinetics, structure, and checkpointsQ35942964
Checkpoint activation regulates mutagenic translesion synthesisQ35963618
DNA polymerases eta and iotaQ35978843
HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistanceQ35998161
Mutator phenotype in cancer: timing and perspectivesQ36020815
Portraits of a Y-family DNA polymeraseQ36024244
Replication of damaged DNA by translesion synthesis in human cellsQ36024250
Structural basis of eukaryotic gene transcriptionQ36024269
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differencesQ36037736
Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelityQ36038818
Ultraviolet radiation-mediated damage to cellular DNA.Q36062298
DNA polymerases that propagate the eukaryotic DNA replication forkQ36090978
DNA replication and progression through S phaseQ36101749
Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instabilityQ36105938
Trading places: how do DNA polymerases switch during translesion DNA synthesis?Q36139683
The DNA trackwalkers: principles of lesion search and recognition by DNA glycosylasesQ36153889
Dynamics of DNA replication: an ultrastructural studyQ45136730
Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus.Q45141943
The role of DNA polymerase eta in UV mutational spectraQ45182075
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.Q45194375
DNA polymerase V and RecA protein, a minimal mutasome.Q45274275
Trinucleotide expansion in haploid germ cells by gap repairQ45302664
Mammalian base excision repair by DNA polymerases delta and epsilonQ45345089
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 geneQ45345090
Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficienciesQ46257980
Lyase activities intrinsic to Escherichia coli polymerases IV and V.Q46365089
To slip or skip, visualizing frameshift mutation dynamics for error-prone DNA polymerasesQ46375749
Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivoQ46493055
Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions.Q46554910
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2pQ46576875
The microarchitecture of DNA replication domainsQ46772884
DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimersQ46786208
Fragmentation of replicating chromosomes triggered by uracil in DNA.Q46811911
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase deltaQ46848079
Loss of DNA polymerase zeta causes chromosomal instability in mammalian cellsQ46882671
Role of DNA polymerase theta in tolerance of endogenous and exogenous DNA damage in mouse B cellsQ46911088
Replication fork reactivation downstream of a blocked nascent leading strandQ46923728
A false note of DNA polymerase iota in the choir of genome caretakers in mammalsQ46953501
Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining stepsQ47724136
Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase deltaQ47791987
Snapshots of replication through an abasic lesion; structural basis for base substitutions and frameshiftsQ47946960
Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extractsQ47988688
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability.Q48033074
DNA polymerase lambda, a novel DNA repair enzyme in human cells.Q48320706
A unified nomenclature for the subunits of eukaryotic DNA polymerase deltaQ48742451
The hypermutability conferred by the mus308 mutation of Drosophila is not specific for cross-linking agents.Q49201420
The Drosophila mus 308 gene product, implicated in tolerance of DNA interstrand crosslinks, is a nuclear protein found in both ovaries and embryos.Q52046900
Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis.Q52138030
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.Q52163744
Cleavage of substrates with mismatched nucleotides by Flap endonuclease-1. Implications for mammalian Okazaki fragment processing.Q52535059
Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.Q52541355
Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.Q52563158
Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.Q53639781
The efficiency and specificity of apurinic/apyrimidinic site bypass by human DNA polymerase eta and Sulfolobus solfataricus Dpo4.Q53650084
The frameshift infidelity of human DNA polymerase lambda. Implications for function.Q53653976
The overexpression of specialized DNA polymerases in cancer.Q53861866
Chloroplast and mitochondrial DNA polymerases from cultured soybean cells.Q54326279
Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity.Q54516425
Analyzing fidelity of DNA polymerases.Q54619712
DNA polymerase epsilon - more than a polymerase.Q54948419
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.Q55034838
The DNA polymerase alpha-primase complex: multiple functions and interactions.Q55109931
Viral proteins functioning in organelles: a cryptic origin?Q56899458
Enzymes of evolutionary changeQ56902070
A novel family of DNA-polymerase-associated B subunitsQ56902375
Proliferating cell nuclear antigen promotes misincorporation catalyzed by calf thymus DNA polymerase deltaQ56903200
Genomes in Flux: The Evolution of Archaeal and Proteobacterial Gene ContentQ56918343
Orthology, paralogy and proposed classification for paralog subtypesQ57444232
Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV LesionsQ58883733
Origin of Antibody VariationQ59057486
Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxideQ59062693
A unified polymerase mechanism for nonhomologous DNA and RNA polymerasesQ63383689
Deubiquitinating PCNA: a downside to DNA damage toleranceQ63965422
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymeraseQ64388607
DNA replication errors produced by the replicative apparatus of Escherichia coli.Q64994677
Fidelity of mammalian DNA replication and replicative DNA polymerasesQ67780868
Evidence favouring the hypothesis of a conserved 3'-5' exonuclease active site in DNA-dependent DNA polymerasesQ68079183
Active center of DNA polymeraseQ68590085
Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerasesQ71239708
Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damageQ72167772
Visualization of replication factories attached to nucleoskeletonQ72216658
The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiaeQ72240900
Mismatch extension ability of yeast and human DNA polymerase etaQ73130869
Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreadingQ73188841
Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids: oligomeric structure and functional characterization using in vitro DNA replicationQ73230479
Proofreading of DNA polymerase eta-dependent replication errorsQ73288765
POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathwayQ73319794
Fidelity of human DNA polymerase etaQ73538274
Defective DNA polymerase-delta proofreading causes cancer susceptibility in miceQ73954766
Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in miceQ73963170
Evidence for a second function for Saccharomyces cerevisiae Rev1pQ74130085
An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic deathQ74250699
The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunitQ74371876
Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiaeQ74478617
The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitroQ77172508
The type of DNA glycosylase determines the base excision repair pathway in mammalian cellsQ77754917
The fidelity of DNA polymerase beta during distributive and processive DNA synthesisQ77912079
Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor grooveQ78010351
The Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) BindingQ79241756
Fidelity of DNA polymerase delta holoenzyme from Saccharomyces cerevisiae: the sliding clamp proliferating cell nuclear antigen decreases its fidelityQ79326276
Toward a unified theory for repeat expansionsQ80998259
Pol III proofreading activity prevents lesion bypass as evidenced by its molecular signature within E.coli cellsQ81089140
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase deltaQ82346662
DNA replication fidelity: proofreading in transQ82872821
Human DNA polymerase iota promiscuous mismatch extensionQ33950961
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigenQ33997499
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.Q34006347
Evidence for extrinsic exonucleolytic proofreading.Q34010452
Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletionsQ34082583
DNA mismatch repair and genetic instabilityQ34090778
Eukaryotic DNA polymerases: proposal for a revised nomenclature.Q34093113
Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domainQ34097492
Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Q34098247
Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phaseQ34104931
Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).Q34127066
Evolution of DNA polymerase families: evidences for multiple gene exchange between cellular and viral proteinsQ34130096
Active site tightness and substrate fit in DNA replicationQ34131462
DNA polymerase theta purified from human cells is a high-fidelity enzymeQ34132140
Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.Q34147661
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Q34157224
The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesisQ34161890
hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsQ34161894
Mutagenesis and deoxyribonucleotide pool imbalanceQ34172708
Discovery of DNA polymeraseQ34203766
Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthdayQ34229913
Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1Q34234530
The contribution of endogenous sources of DNA damage to the multiple mutations in cancerQ34263814
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndromeQ34277881
Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappaQ34321226
Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeastQ34324101
Repair of DNA interstrand cross-linksQ34343361
DNA polymerases and somatic hypermutation of immunoglobulin genesQ34360690
AID to overcome the limitations of genomic informationQ36170796
Mapping replicational sites in the eucaryotic cell nucleusQ36219820
Nucleotide excision repairQ36226849
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Q36248087
The RAD6 pathway: control of DNA damage bypass and mutagenesis by ubiquitin and SUMO.Q36249152
Recent advances in understanding of the DNA double-strand break repair machinery of plants.Q36275861
Repeat instability: mechanisms of dynamic mutationsQ36277189
Structure-function studies of DNA polymerase lambda.Q36280679
Structure and mechanism of DNA polymerasesQ36288580
Mechanisms of common fragile site instability.Q36294681
Retention of replication fidelity by a DNA polymerase functioning in a distantly related environmentQ36300728
Immunoglobulin gene diversificationQ36312189
Nonhomologous end joining in yeastQ36312212
SUMO keeps a check on recombination during DNA replication.Q36315491
The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancerQ36317650
Homologous recombination is promoted by translesion polymerase poletaQ36335965
Suffering in silence: the tolerance of DNA damageQ36337954
DNA precursor asymmetries, replication fidelity, and variable genome evolutionQ36350924
Fanconi anemia (cross)linked to DNA repairQ36353502
Error-prone candidates vie for somatic mutationQ36368573
Molecular mechanisms of mammalian global genome nucleotide excision repair.Q36389623
Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repairQ36389685
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.Q36399002
DNA damage responses and their many interactions with the replication forkQ36402069
Inducible DNA breaks in Ig S regions are dependent on AID and UNGQ36402801
Translesion synthesis DNA polymerases and control of genome stabilityQ36486621
Mechanisms for chromosome and plasmid segregationQ36498320
Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutationQ36533627
A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repairQ36553838
Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilonQ36573422
Bacteriophage T4 DNA polymerase mutations that confer sensitivity to the PPi analog phosphonoacetic acidQ36638832
Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproductsQ36690666
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.Q44785638
Pre-steady-state kinetic studies of the fidelity and mechanism of polymerization catalyzed by truncated human DNA polymerase lambdaQ44905728
The DNA replication fork in eukaryotic cells.Q27939216
The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNAQ27939424
The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunitQ27939620
Processing and joining of DNA ends coordinated by interactions among Dnl4/Lif1, Pol4, and FEN-1.Q27939628
DNA polymerases alpha, delta, and epsilon localize and function together at replication forks in Saccharomyces cerevisiae.Q27939720
Lesion bypass in yeast cells: Pol eta participates in a multi-DNA polymerase processQ27939810
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesisQ27939891
Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiaeQ27940267
Regulation of monoubiquitinated PCNA by DUB autocleavageQ28115531
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase etaQ28115711
Terminal deoxynucleotidyl transferase and repertoire developmentQ28143017
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2Q28144150
Proliferating cell nuclear antigen is required for DNA excision repairQ28182009
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genesQ28190856
Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase muQ28202970
Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteinsQ28203223
Chromosomal stability and the DNA double-stranded break connectionQ28205315
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repairQ28207004
Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.Q39757351
DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiaeQ40016053
Fidelity of DNA synthesisQ40113209
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombinationQ40240123
The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repairQ40273191
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota.Q40323781
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesisQ40342097
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombinationQ40342102
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathwayQ40376906
Analysis of the spontaneous mutator phenotype associated with 20S proteasome deficiency in S. cerevisiaeQ40386308
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repairQ40400659
Somatic hypermutationQ40404787
Compilation, alignment, and phylogenetic relationships of DNA polymerasesQ40405362
DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cellsQ40410915
Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblastsQ40424267
Yeast DNA polymerases and their role at the replication fork.Q40478357
Conformational coupling in DNA polymerase fidelityQ40489077
Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappaQ40505709
Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesisQ40525107
Learning about DNA polymerase function by studying antimutator DNA polymerasesQ40539092
Recombinogenic phenotype of human activation-induced cytosine deaminase.Q40575833
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.Q40591358
Role of DNA polymerase eta in the UV mutation spectrum in human cellsQ40663020
High-performance liquid chromatography--tandem mass spectrometry measurement of radiation-induced base damage to isolated and cellular DNA.Q40842271
Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta -related enzymeQ40869398
The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicityQ40871857
Molecular dosimetry of chemical mutagens. Relationship between DNA adduct formation and genetic changes analyzed at the molecular levelQ41022862
Structure and function of telomeraseQ41066960
DNA repair in eukaryotesQ41114782
A mitochondrial nuclease is modified in Drosophila mutants (mus308) that are hypersensitive to DNA crosslinking agentsQ41195537
An attempt to unify the structure of polymerasesQ41204694
Cell survival and shuttle vector mutagenesis induced by ultraviolet A and ultraviolet B radiation in a human cell lineQ41211714
Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cellsQ41517133
The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression and DNA-damage responseQ41661201
DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viabilityQ41670559
Analysis of the essential functions of the C-terminal protein/protein interaction domain of Saccharomyces cerevisiae pol epsilon and its unexpected ability to support growth in the absence of the DNA polymerase domainQ41682738
Purification and characterization of mouse DNA polymerase alpha devoid of primase activityQ41717668
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient miceQ41807812
A role for DNA primase in coupling DNA replication to DNA damage response.Q41813482
On molecular mechanisms of nucleic acid synthesis. Fidelity aspects: 2. Contribution of protein-nucleotide recognitionQ41840232
DNA polymerase beta: effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changesQ41854868
DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phaseQ42280794
Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication forkQ42628317
Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta.Q42686703
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblastsQ42813803
The AID enzyme induces class switch recombination in fibroblastsQ42818062
A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelityQ43509472
Fidelity of nucleotide insertion at 8-oxo-7,8-dihydroguanine by mammalian DNA polymerase delta. Steady-state and pre-steady-state kinetic analysisQ43511401
Modulation of RecA nucleoprotein function by the mutagenic UmuD'C protein complexQ43565938
Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesisQ43586184
Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeastQ43639973
In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.Q43767918
Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcriptionQ43815506
Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras geneQ43831017
Yeast origins establish a strand bias for replicational mutagenesis.Q44084614
Replication factoriesQ44126447
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient miceQ44194766
Transfer of the MSH2.MSH6 complex from proliferating cell nuclear antigen to mispaired bases in DNA.Q44219222
Induction of DNA replication-mediated double strand breaks by psoralen DNA interstrand cross-linksQ44243364
The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair.Q44432071
The U.V. sensitivity of bacteria: its relation to the DNA replication cycleQ44434304
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.Q44460153
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutationQ44486460
P304page(s)41-132
P577publication date2006-01-01
P1433published inInternational Review of CytologyQ2687019
P1476titleRoles of DNA polymerases in replication, repair, and recombination in eukaryotes
P478volume255

Reverse relations

cites work (P2860)
Q36857452A highly conserved family of inactivated archaeal B family DNA polymerases
Q28652503A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae
Q28475041A nuclear family A DNA polymerase from Entamoeba histolytica bypasses thymine glycol
Q34059478A time-invariant principle of genome evolution
Q53836474Activity and fidelity of human DNA polymerase α depend on primer structure.
Q33330892Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21.
Q27024636Antimutator variants of DNA polymerases
Q33828325Break-induced replication is highly inaccurate
Q38592304Contiguous 2,2,4-triamino-5(2H)-oxazolone obstructs DNA synthesis by DNA polymerases α, β, η, ι, κ, REV1 and Klenow Fragment exo-, but not by DNA polymerase ζ.
Q42430280Crystallization and preliminary crystallographic analysis of the complex of the second and third regulatory subunits of human Pol delta
Q33399955DNA polymerase delta is required for early mammalian embryogenesis
Q37386020DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice
Q28263318DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ
Q46665792DNA polymerase η mutational signatures are found in a variety of different types of cancer
Q34795963DNA polymerases and human disease
Q28255094DNA polymerases at the eukaryotic fork-20 years later
Q42353167DNA repair: How to accurately bypass damage
Q28295863DNA replication fidelity and cancer
Q28547015Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes
Q34295773Domain structures and inter-domain interactions defining the holoenzyme architecture of archaeal d-family DNA polymerase
Q37676238Elaborated Action of the Human Primosome
Q36643853Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast
Q39022234Eukaryotic DNA Polymerases in Homologous Recombination
Q24316458Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links
Q30487081Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
Q36178814Evolutionary switches between two serine codon sets are driven by selection
Q36437010Extraordinary genome stability in the ciliate Paramecium tetraurelia
Q34778532Fragile DNA motifs trigger mutagenesis at distant chromosomal loci in saccharomyces cerevisiae
Q34176623Generalized portrait of cancer metabolic pathways inferred from a list of genes overexpressed in cancer
Q37414576High fidelity and lesion bypass capability of human DNA polymerase delta
Q64081096Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit
Q28581063Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning
Q33815583Inaccurate DNA synthesis in cell extracts of yeast producing active human DNA polymerase iota
Q88626544Iron-Sulfur Clusters in DNA Polymerases and Primases of Eukaryotes
Q37404117LINEs of evidence: noncanonical DNA replication as an epigenetic determinant
Q37136907Lesion processing: high-fidelity versus lesion-bypass DNA polymerases
Q37716240Measurements of spontaneous rates of mutations in the recent past and the near future
Q30754178Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome
Q39293345Mechanisms of DNA damage, repair, and mutagenesis
Q34629238Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain
Q35068836Modulation of macrophage activities in proliferation, lysosome, and phagosome by the nonspecific immunostimulator, mica
Q37483304Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools
Q38045848Mouse models of DNA polymerases.
Q28245001Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis
Q34055320Mutator suppression and escape from replication error-induced extinction in yeast
Q34323807Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases
Q35677477Optimization of Mutation Pressure in Relation to Properties of Protein-Coding Sequences in Bacterial Genomes
Q37482417PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.
Q33628462Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae
Q38954610Phenotypic characterization of missense polymerase-δ mutations using an inducible protein-replacement system
Q49388555Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.
Q35837411Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.
Q92488841Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements
Q26825747Replicative DNA polymerase mutations in cancer
Q41983355Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
Q26829680Structural insights into eukaryotic DNA replication
Q36140655Subunit sharing among high- and low-fidelity DNA polymerases
Q33304452Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication
Q34070370The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex
Q27678074The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition
Q54373923The effect of aging on the DNA damage and repair capacity in 2BS cells undergoing oxidative stress.
Q35062343The pattern of DNA cleavage intensity around indels
Q42467404The role of DNA polymerase alpha in the control of mutagenesis in Saccharomyces cerevisiae cells starved for nutrients
Q36395769Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements
Q27652299X-ray structure of the complex of regulatory subunits of human DNA polymerase delta

Search more.