Fidelity of human DNA polymerase eta

scientific article published on 01 March 2000

Fidelity of human DNA polymerase eta is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.275.11.7447
P698PubMed publication ID10713043

P50authorTodd WashingtonQ73118418
P2093author name stringL Prakash
S Prakash
R E Johnson
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)7447-7450
P577publication date2000-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleFidelity of human DNA polymerase eta
P478volume275

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cites work (P2860)
Q28587504129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation
Q402404538-Hydroxyguanine in a mutational hotspot of the c-Ha-ras gene causes misreplication, 'action-at-a-distance' mutagenesis and inhibition of replication
Q36783631A high-throughput and quantitative method to assess the mutagenic potential of translesion DNA synthesis
Q24646838A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair
Q40493478A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA.
Q37326124A novel POLH mutation causes XP-V disease and XP-V tumor proneness may involve imbalance of numerous DNA polymerases.
Q37406038A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases
Q36315292A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine
Q33714583A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis
Q43509472A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity
Q40669326A single site-specific trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct induces mutations at multiple sites in DNA.
Q36619097A strategy for the expression of recombinant proteins traditionally hard to purify
Q35068183AID to overcome the limitations of genomic information by introducing somatic DNA alterations
Q40463112ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts
Q41720039Aberrant Kynurenine Signaling Modulates DNA Replication Stress Factors and Promotes Genomic Instability in Gliomas
Q42579444Acceleration of 5-methylcytosine deamination in cyclobutane dimers by G and its implications for UV-induced C-to-T mutation hotspots
Q27938785Accessibility of DNA polymerases to repair synthesis during nucleotide excision repair in yeast cell-free extracts
Q37097247Accuracy of lesion bypass by yeast and human DNA polymerase eta.
Q39458346Acidic residues critical for the activity and biological function of yeast DNA polymerase eta.
Q49411576Age Is Relative-Impact of Donor Age on Induced Pluripotent Stem Cell-Derived Cell Functionality
Q24535441Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.
Q44367170Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta.
Q42157040Architecture of Y‐Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies
Q40686398Asymmetry of DNA replication and translesion synthesis of UV-induced thymine dimers
Q27671647Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases
Q35780144Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability
Q36893377Biochemical analysis of active site mutations of human polymerase η
Q91752832Biochemical reconstitution of UV-induced mutational processes
Q46465906Cancer in xeroderma pigmentosum and related disorders of DNA repair
Q38630779Characterization of Escherichia coli UmuC active-site loops identifies variants that confer UV hypersensitivity
Q34155778Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana.
Q35963618Checkpoint activation regulates mutagenic translesion synthesis
Q40773301Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer
Q45722526Cloning and characterization of DNA polymerase eta from Trypanosoma cruzi: roles for translesion bypass of oxidative damage
Q36417607Comparative Molecular Dynamics Studies of Human DNA Polymerase η.
Q34097492Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain
Q35221381Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions
Q27634747Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain
Q27635332Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication
Q34375816DNA lesion bypass polymerases open up.
Q35088992DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes
Q28190856DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
Q33935129DNA polymerase eta lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells
Q40777650DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination
Q24523653DNA polymerase iota and related rad30-like enzymes
Q37084895DNA polymerases and cancer.
Q34360690DNA polymerases and somatic hypermutation of immunoglobulin genes
Q35978843DNA polymerases eta and iota
Q38707053DNA replication stress: from molecular mechanisms to human disease
Q37122141DNA-damage tolerance mediated by PCNA*Ub fusions in human cells is dependent on Rev1 but not Polη.
Q39743644Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases
Q33933937Distinct mechanisms of cis-syn thymine dimer bypass by Dpo4 and DNA polymerase eta
Q38304800Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells
Q47785542Dpo4 is hindered in extending a G.T mismatch by a reverse wobble
Q33289766Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase eta.
Q21146665Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
Q36735122Efficient and accurate bypass of N2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo.
Q24563650Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa
Q36701342Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.
Q37509255Enzymatic switching for efficient and accurate translesion DNA replication.
Q34958722Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine
Q37044564Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA.
Q29619958Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions
Q33924989Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa
Q36380466Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA.
Q34244261Evolution of the two-step model for UV-mutagenesis
Q35253312Exploiting CpG hypermutability to identify phenotypically significant variation within human protein-coding genes
Q34053164Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens
Q43734029Fidelity and damage bypass ability of Schizosaccharomyces pombe Eso1 protein, comprised of DNA polymerase eta and sister chromatid cohesion protein Ctf7.
Q45345090Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene
Q35047056Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.
Q46076427Genome sequence and splice site analysis of low-fidelity DNA polymerases H and I involved in replication of damaged DNA
Q36395930Genomic approaches to DNA repair and mutagenesis
Q37416480Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells
Q39529040Highly frequent frameshift DNA synthesis by human DNA polymerase mu
Q24534772Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini
Q34097175Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA.
Q36222886Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base.
Q35127456Human DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini.
Q24670499Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions
Q73794909Human DNA repair genes
Q39898806In Vitro Lesion Bypass Studies of O(4)-Alkylthymidines with Human DNA Polymerase η.
Q36412869In-vitro replication studies on O(2)-methylthymidine and O(4)-methylthymidine
Q31655742Inefficient bypass of an abasic site by DNA polymerase eta.
Q27935721Interaction with PCNA is essential for yeast DNA polymerase eta function
Q24291530Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7
Q37477870Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change
Q35840281Kinetic analysis of the bypass of a bulky DNA lesion catalyzed by human Y-family DNA polymerases.
Q33247452Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations
Q35978856Mammalian Pol kappa: regulation of its expression and lesion substrates.
Q28209176Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells
Q42108252Mechanism of efficient and accurate nucleotide incorporation opposite 7,8-dihydro-8-oxoguanine by Saccharomyces cerevisiae DNA polymerase eta.
Q36348337Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta.
Q27677864Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.
Q24678700Mechanisms of accurate translesion synthesis by human DNA polymerase eta
Q28608973Mechanisms of human DNA repair: an update
Q24597750Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota
Q33827666Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct
Q33196452Molecular genetics of Xeroderma pigmentosum variant.
Q34542246Molecular mechanism of class switch recombination: linkage with somatic hypermutation
Q28211799Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells
Q38298148Molecular regulation of UV-induced DNA repair
Q41789554Mutagenesis and repair induced by the DNA advanced glycation end product N2-1-(carboxyethyl)-2'-deoxyguanosine in human cells
Q47072057Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota
Q33997247Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNA
Q36885382Mutation rate variation in multicellular eukaryotes: causes and consequences
Q24536098Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions
Q36247787Mutator alleles of yeast DNA polymerase zeta.
Q43639973Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeast
Q47747085NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro.
Q47143560Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
Q34244249Nucleotide excision repair "a legacy of creativity".
Q37731934Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae
Q38339361Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa
Q91625973Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis
Q36483930Photobiological Origins of the Field of Genomic Maintenance
Q24548300Physical and functional interactions of human DNA polymerase eta with PCNA
Q34387678Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene
Q30881342Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair
Q34078421Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta.
Q34139948Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase delta
Q35400041Pre-steady state kinetic studies show that an abasic site is a cognate lesion for the yeast Rev1 protein
Q44785638Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.
Q39455619Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota
Q35868158Preparation of site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase η
Q73288765Proofreading of DNA polymerase eta-dependent replication errors
Q34513802Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases
Q39669447Quantum biological channel modeling and capacity calculation
Q24563236Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination
Q43161636Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase eta.
Q36879506Regulation of therapeutic resistance in cancers by receptor tyrosine kinases
Q28087183Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins
Q36196990Relative Binding Free Energies of Adenine and Guanine to Damaged and Undamaged DNA in Human DNA Polymerase η: Clues for Fidelity and Overall Efficiency
Q44978896Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing
Q28678572Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease
Q27641791Replication of a cis-syn thymine dimer at atomic resolution
Q30746296Replication of damaged DNA in mammalian cells: new solutions to an old problem
Q27930712Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.
Q38847971Replicative Bypass Studies of α-Anomeric Lesions of 2'-Deoxyribonucleosides in Vitro
Q39407326Replicative Bypass of O(2)-Alkylthymidine Lesions in Vitro
Q39468393Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts
Q27931472Requirement of Nse1, a subunit of the Smc5-Smc6 complex, for Rad52-dependent postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae
Q34276876Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae
Q35107864Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta.
Q36424899Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ
Q27934499Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.
Q54637439Role of AtPolζ, AtRev1, and AtPolη in UV light-induced mutagenesis in Arabidopsis.
Q37240545Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast.
Q40663020Role of DNA polymerase eta in the UV mutation spectrum in human cells
Q27939380Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct
Q24541478Role of human DNA polymerase kappa as an extender in translesion synthesis
Q34246606Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.
Q36687824Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.
Q28363488Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites
Q54255023Rose myrtle (Rhodomyrtus tomentosa) extract and its component, piceatannol, enhance the activity of DNA polymerase and suppress the inflammatory response elicited by UVB‑induced DNA damage in skin cells.
Q44580538Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota
Q35083472Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites
Q28475702Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions
Q24537135Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.
Q27655470Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase ι
Q91198592Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η
Q39872612Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.
Q27640288Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential
Q27655720Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion
Q27655583Structure of the Human Rev1–DNA–dNTP Ternary Complex
Q27634744Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis
Q43087758Substitution of a residue contacting the triphosphate moiety of the incoming nucleotide increases the fidelity of yeast DNA polymerase zeta
Q33988449Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta
Q30769976Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.
Q35730103Telomere dysfunction drives increased mutation by error-prone polymerases Rev1 and zeta in Saccharomyces cerevisiae
Q38772764The Establishment of an Assay to Measure DNA Polymerase-Catalyzed Repair of UVB-Induced DNA Damage in Skin Cells and Screening of DNA Polymerase Enhancers from Medicinal Plants
Q89472650The active site residues Gln55 and Arg73 play a key role in DNA damage bypass by S. cerevisiae Pol η
Q24683573The human DINB1 gene encodes the DNA polymerase Poltheta
Q36099918The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance
Q37057343The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme.
Q34978882The roles of DNA polymerases κ and ι in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells.
Q36248087The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.
Q34268165The unusual UBZ domain of Saccharomyces cerevisiae polymerase η
Q36588936The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta
Q48174480Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities
Q34356338Translesion DNA polymerases
Q39171293Translesion DNA polymerases in eukaryotes: what makes them tick?
Q38086224Translesion DNA synthesis and mutagenesis in eukaryotes
Q37118430Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one.
Q43509259Translesion DNA synthesis by yeast DNA polymerase eta on templates containing N2-guanine adducts of 1,3-butadiene metabolites
Q43619478Translesion DNA synthesis catalyzed by human pol eta and pol kappa across 1,N6-ethenodeoxyadenosine.
Q37952001Translesion DNA synthesis in the context of cancer research
Q34479547Translesion Synthesis across Abasic Lesions by Human B-Family and Y-Family DNA Polymerases α, δ, η, ι, κ, and REV1
Q44533872Translesion replication in cisplatin-treated xeroderma pigmentosum variant cells is also caffeine-sensitive: features of the error-prone DNA polymerase(s) involved in UV-mutagenesis
Q24540425Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota
Q33953024Translesion synthesis by the UmuC family of DNA polymerases
Q39095697Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene
Q42686703Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta.
Q24290234Two novel human and mouse DNA polymerases of the polX family
Q33400985Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
Q35131714UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota
Q33584166UV-induced T-->C transition at a TT photoproduct site is dependent on Saccharomyces cerevisiae polymerase eta in vivo
Q36580842Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι
Q54546880Ubiquitous expression of two translesion synthesis DNA polymerase genes in Arabidopsis.
Q59138263Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication
Q34597716Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis
Q24535948Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines
Q33756190Variations on a theme: eukaryotic Y-family DNA polymerases
Q24309639Werner syndrome protein interacts functionally with translesion DNA polymerases
Q36023692What a difference a decade makes: insights into translesion DNA synthesis
Q34464872Why do cells have multiple error-prone DNA polymerases?
Q77456297Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation
Q27934657Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol
Q34473133Yeast DNA polymerase zeta is an efficient extender of primer ends opposite from 7,8-dihydro-8-Oxoguanine and O6-methylguanine
Q34982065Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate
Q37239015Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase delta
Q79773215Yeast and human translesion DNA synthesis polymerases: expression, purification, and biochemical characterization
Q91864626cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy
Q24604217poliota, a remarkably error-prone human DNA polymerase
Q35013038poliota-dependent lesion bypass in vitro

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