Suffering in silence: the tolerance of DNA damage

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Suffering in silence: the tolerance of DNA damage is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/NRM1781
P698PubMed publication ID16341080

P2093author name stringErrol C Friedberg
P2860cites workhRAD30 mutations in the variant form of xeroderma pigmentosumQ22010237
Eukaryotic DNA PolymerasesQ22065416
Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer terminiQ24534772
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.Q24537708
Role of human DNA polymerase kappa as an extender in translesion synthesisQ24541478
The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein familyQ24548218
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitinationQ24563236
Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient miceQ40429467
Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappaQ40505709
The Saccharomyces cerevisiae RAD18 gene encodes a protein that contains potential zinc finger domains for nucleic acid binding and a putative nucleotide binding sequenceQ40554098
Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cellsQ40559170
The RAD6 DNA repair pathway in Saccharomyces cerevisiae: what does it do, and how does it do it?Q40671595
The RAD6 gene and protein of Saccharomyces cerevisiaeQ40707410
Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesisQ40958827
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.Q44785638
The biochemical requirements of DNA polymerase V-mediated translesion synthesis revisitedQ44995077
DNA polymerase V and RecA protein, a minimal mutasome.Q45274275
Positive torsional strain causes the formation of a four-way junction at replication forksQ46674361
Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa.Q47614597
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability.Q48033074
Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota.Q53736324
Repair of radiation-induced damage in Escherichia coli. I. Effect of rec mutations on post-replication repair of damage due to ultraviolet radiation.Q53740414
DNA damage-induced replication fork regression and processing in Escherichia coli.Q54531654
Pivotal role of the beta-clamp in translesion DNA synthesis and mutagenesis in E. coli cells.Q54532729
The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene.Q54777328
Error-Prone DNA PolymerasesQ60998760
Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork BarrierQ63383718
A model for replication repair in mammalian cellsQ67440139
Discontinuities in the DNA synthesized in an Excision-defective strain of Escherichia coli following ultraviolet irradiationQ69833258
Usefulness of benzoylated naphthoylated DEAE-cellulose to distinguish and fractionate double-stranded DNA bearing different extents of single-stranded regionsQ69928475
The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesisQ72994394
UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiaeQ73741858
Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutationQ77892518
Error-free recombinational repair predominates over mutagenic translesion replication in E. coliQ78482138
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesisQ24594244
All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesisQ24597093
Historical overview: searching for replication help in all of the rec placesQ24631768
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesisQ24794355
The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzymeQ27933609
Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.Q27935427
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activitiesQ27938794
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase etaQ28115711
RING finger proteins: mediators of ubiquitin ligase activityQ28139717
Initiation of genetic recombination and recombination-dependent replicationQ28141289
Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase muQ28202970
RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repairQ28207059
Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defectsQ28216078
Interaction of hREV1 with three human Y-family DNA polymerasesQ28266239
Replication protein A phosphorylation and the cellular response to DNA damageQ28274289
Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl proteinQ28283240
Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblastsQ28586777
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutationQ28587504
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damageQ28646728
Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human diseaseQ28678572
The importance of repairing stalled replication forksQ29614220
The Y-family of DNA polymerasesQ29615308
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugationQ29619155
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivityQ30641251
Replication of damaged DNA in mammalian cells: new solutions to an old problemQ30746296
Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.Q30769976
A requirement for replication in activation of the ATR-dependent DNA damage checkpointQ30848079
The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replicationQ31422789
DNA recombination: the replication connection.Q33677006
Novel DNA polymerases offer clues to the molecular basis of mutagenesisQ33730736
Role of PriA in replication fork reactivation in Escherichia coliQ33805205
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationQ33853914
Multiple pathways process stalled replication forksQ35870700
Cellular functions of DNA polymerase zeta and Rev1 proteinQ35978838
Filling the gaps in replication restart pathways.Q36076269
An update on the role of translesion synthesis DNA polymerases in Ig hypermutationQ36083527
Error-prone DNA repair and translesion synthesis: focus on the replication forkQ36089826
Discontinuous or semi-discontinuous DNA replication in Escherichia coli?Q36126246
Trading places: how do DNA polymerases switch during translesion DNA synthesis?Q36139683
Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.Q36275662
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouseQ36403507
Fidelity mechanisms in DNA replicationQ37285267
Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase IIIQ37296938
Enzymatic switching for efficient and accurate translesion DNA replication.Q37509255
Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functionsQ37732412
Mutation induced by DNA damage: a many protein affairQ37892175
Identification of specific amino acid residues in the E. coli beta processivity clamp involved in interactions with DNA polymerase III, UmuD and UmuD'.Q38340491
Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. II. Further evidence for a novel function in error-prone repairQ39902883
Inactivation of the Escherichia coli priA DNA replication protein induces the SOS responseQ39945614
Defining the position of the switches between replicative and bypass DNA polymerasesQ40253650
Replication and recombination intersectQ33885019
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 geneQ33920689
Recombinational repair and restart of damaged replication forks.Q33962242
Quantitative measurement of translesion replication in human cells: evidence for bypass of abasic sites by a replicative DNA polymeraseQ34020161
Preferential binding of ATR protein to UV-damaged DNA.Q34067234
Error-prone repair DNA polymerases in prokaryotes and eukaryotesQ34131455
Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotidesQ34141563
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Q34157224
Damage repair DNA polymerases Y.Q34176729
Uncoupling of leading- and lagging-strand DNA replication during lesion bypass in vivoQ34199558
Therefore, what are recombination proteins there for?Q34243612
Evolution of the two-step model for UV-mutagenesisQ34244261
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndromeQ34277881
Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyreneQ34387678
Recombinational DNA repair of damaged replication forks in Escherichia coli: questionsQ34432200
Specialized DNA polymerases, cellular survival, and the genesis of mutationsQ34662609
The bacterial RecA protein and the recombinational DNA repair of stalled replication forksQ34667410
Genome stability and the processing of damaged replication forks by RecG.Q34762160
Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affairQ34770150
Toward maintaining the genome: DNA damage and replication checkpointsQ34995489
Checking on the fork: the DNA-replication stress-response pathwayQ35006441
The nonmutagenic repair of broken replication forks via recombinationQ35013053
How DNA lesions are turned into mutations within cells?Q35026386
DNA structure dependent checkpoints as regulators of DNA repairQ35046592
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.Q35047056
Association of phiX174 DNA-dependent ATPase activity with an Escherichia coli protein, replication factor Y, required for in vitro synthesis of phiX174 DNAQ35087454
Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase.Q35132468
Biological functions of translesion synthesis proteins in vertebratesQ35296361
Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get AheadQ35582961
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.Q35588920
The DNA replication priming protein, PriA, is required for homologous recombination and double-strand break repairQ35603171
Xeroderma pigmentosum variant and error-prone DNA polymerasesQ35630346
Post-replication repair in DT40 cells: translesion polymerases versus recombinasesQ35639954
Error-prone replication for better or worseQ35785643
Translesion DNA synthesis: little fingers teach toleranceQ35798500
Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerasesQ35804585
P433issue12
P921main subjectDNA damageQ5205747
P304page(s)943-953
P577publication date2005-12-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleSuffering in silence: the tolerance of DNA damage
P478volume6

Reverse relations

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