Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get Ahead

scientific article published on January 1, 2003

Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get Ahead is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1146/ANNUREV.GENET.37.042203.132748
P953full work available at URLhttps://www.annualreviews.org/doi/pdf/10.1146/annurev.genet.37.042203.132748
P698PubMed publication ID14616055
P5875ResearchGate publication ID9010475

P2093author name stringJeffrey N. Strathern
Alison J. Rattray
P2860cites workCancer ResearchQ326097
The yeast Saccharomyces cerevisiae DNA polymerase IV: possible involvement in double strand break DNA repairQ35009312
poliota-dependent lesion bypass in vitroQ35013038
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.Q35047056
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.Q35588920
A phenotype for enigmatic DNA polymerase II: a pivotal role for pol II in replication restart in UV-irradiated Escherichia coliQ35600177
The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecinQ22009054
Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymeraseQ22010228
hRAD30 mutations in the variant form of xeroderma pigmentosumQ22010237
The human REV1 gene codes for a DNA template-dependent dCMP transferaseQ22010721
Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinBQ22011012
Eukaryotic DNA PolymerasesQ22065416
Two novel human and mouse DNA polymerases of the polX familyQ24290234
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase etaQ24515346
The processivity factor beta controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis in vivoQ24522537
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).Q24532243
DNA polymerase II of Escherichia coli in the bypass of abasic sites in vivoQ24532905
Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer terminiQ24534772
Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.Q24535441
Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosinesQ24535948
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.Q24537135
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repairQ24540101
Role of human DNA polymerase kappa as an extender in translesion synthesisQ24541478
Physical and functional interactions of human DNA polymerase eta with PCNAQ24548300
Adaptive mutation: implications for evolutionQ24623723
Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNAQ24628966
Association of terminal deoxynucleotidyl transferase with KuQ24642971
Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugsQ24644933
The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV lightQ24681973
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseQ24683335
The human DINB1 gene encodes the DNA polymerase PolthetaQ24683573
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesisQ27634744
Deoxycytidyl transferase activity of yeast REV1 proteinQ27931173
Specificity of DNA lesion bypass by the yeast DNA polymerase eta.Q27933149
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.Q27934276
Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycolQ27934657
A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joiningQ27935436
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, PoletaQ27935465
Interaction with PCNA is essential for yeast DNA polymerase eta functionQ27935721
UV mutagenesis in radiation-sensitive strains of yeastQ27936517
Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiaeQ27936722
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Removal of nonhomologous DNA ends in double-strand break recombination: the role of the yeast ultraviolet repair gene RAD1Q27937863
Thymine-thymine dimer bypass by yeast DNA polymerase zetaQ27938043
Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB geneQ35608675
The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancerQ35917705
Checkpoint activation regulates mutagenic translesion synthesisQ35963618
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Q36248087
The role of transient hypermutators in adaptive mutation in Escherichia coliQ36384221
Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutationQ36533627
Cloning of terminal transferase cDNA by antibody screeningQ36586899
Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variantQ36796836
Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependenceQ37096423
Accuracy of lesion bypass by yeast and human DNA polymerase eta.Q37097247
The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 3' thymine-to-cytosine transitions in Escherichia coliQ37612232
Yeast Rev1 protein is a G template-specific DNA polymeraseQ38291977
Differential gene expression in human cancer cells resistant to cisplatinQ38777017
Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluoreneQ39095697
Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iotaQ39455619
Highly frequent frameshift DNA synthesis by human DNA polymerase muQ39529040
Terminal deoxynucleotidyl transferase catalyzes the reaction of DNA phosphorylationQ39542477
Formation of an F' plasmid by recombination between imperfectly repeated chromosomal Rep sequences: a closer look at an old friend (F'(128) pro lac).Q39714248
Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cellsQ39841075
Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. I. rev1 Mutant strainsQ40160734
DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cellsQ40410915
AID is essential for immunoglobulin V gene conversion in a cultured B cell lineQ40746479
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutationQ40782991
Increased transcription levels induce higher mutation rates in a hypermutating cell lineQ40814374
Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genesQ40840741
Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet lightQ40850491
Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta -related enzymeQ40869398
The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicityQ40871857
Role of DNA polymerase beta in the excision step of long patch mammalian base excision repairQ40955413
Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesisQ40958827
Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoireQ41126132
A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energyQ41203605
The mechanism of untargeted mutagenesis in UV-irradiated yeastQ41618996
Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesisQ41734679
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activityQ41869549
The Escherichia coli polB locus is identical to dinA, the structural gene for DNA polymerase II. Characterization of Pol II purified from a polB mutantQ42652215
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation processQ42944711
DNA double-strand breaks: prior to but not sufficient in targeting hypermutationQ42944715
Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavageQ43432570
Terminal deoxynucleotidyl transferase indiscriminately incorporates ribonucleotides and deoxyribonucleotidesQ43640424
Roles of chromosomal and episomal dinB genes encoding DNA pol IV in targeted and untargeted mutagenesis in Escherichia coli.Q43781879
Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcriptionQ43815506
Efficiency and accuracy of SOS-induced DNA polymerases replicating benzo[a]pyrene-7,8-diol 9,10-epoxide A and G adductsQ43816434
Mistranslation induced by streptomycin provokes a RecABC/RuvABC-dependent mutator phenotype in Escherichia coli cellsQ43866930
Repair of cyclobutyl pyrimidine dimers in human skin: variability among normal humans in nucleotide excision and in photorepairQ44122773
Lesion bypass activities of human DNA polymerase mu.Q44135115
DNA polymerase III from Escherichia coli cells expressing mutA mistranslator tRNA is error-proneQ44153069
Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase zeta in vitroQ44179104
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient miceQ44194766
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitroQ33938237
The "tale" of UmuD and its role in SOS mutagenesisQ33957289
Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli.Q33966542
The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage toleranceQ34090796
Eukaryotic DNA polymerases: proposal for a revised nomenclature.Q34093113
Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Q34098247
Error-prone repair DNA polymerases in prokaryotes and eukaryotesQ34131455
DNA polymerase theta purified from human cells is a high-fidelity enzymeQ34132140
Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotidesQ34141563
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Q34157224
Localisation of human DNA polymerase kappa to replication fociQ34157610
hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsQ34161894
Damage repair DNA polymerases Y.Q34176729
DNA damage control by novel DNA polymerases: translesion replication and mutagenesisQ34260300
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndromeQ34277881
Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytesQ34353297
Mice lacking TdT: mature animals with an immature lymphocyte repertoireQ34353306
Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyreneQ34387678
Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogensQ34392595
Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC.Q34446488
Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase betaQ34668670
Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affairQ34770150
Polymerase mu is a DNA-directed DNA/RNA polymeraseQ34784888
Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathwayQ27938668
The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanismQ27938714
Role of DNA polymerase eta in the bypass of a (6-4) TT photoproductQ27939380
The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNAQ27939424
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase etaQ28115711
Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase etaQ28116380
Transcription-targeted DNA deamination by the AID antibody diversification enzymeQ28190732
DNA polymerase beta expression differences in selected human tumors and cell linesQ28198269
The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variantQ28203111
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesisQ28205678
Mechanism of DNA polymerase II-mediated frameshift mutagenesisQ28205789
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repairQ28207004
Error rate and specificity of human and murine DNA polymerase etaQ28216092
Rate of depurination of native deoxyribonucleic acidQ28243811
Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNAQ28360244
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingQ28366125
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cellsQ28509339
DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosisQ28586606
Distinct and opposite diversifying activities of terminal transferase splice variantsQ28587746
Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testisQ28645719
Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitroQ28646677
Hypermutation in derepressed operons of Escherichia coli K12Q28776505
The Y-family of DNA polymerasesQ29615308
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
Pol kappa: A DNA polymerase required for sister chromatid cohesion.Q30305921
Evidence that replication fork components catalyze establishment of cohesion between sister chromatidsQ30454198
DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary historyQ30559537
Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.Q30769976
The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replicationQ31422789
A model for SOS-lesion-targeted mutations in Escherichia coliQ32001102
Somatic hypermutation and the three R's: repair, replication and recombinationQ33545735
Hypermutation in bacteria and other cellular systemsQ33770256
Analysis of damage tolerance pathways in Saccharomyces cerevisiae: a requirement for Rev3 DNA polymerase in translesion synthesisQ33771455
Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosumQ33853150
Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutationQ33886793
Genetics of mutagenesis in E. coli: various combinations of translesion polymerases (Pol II, IV and V) deal with lesion/sequence context diversityQ44267628
Translesion synthesis past platinum DNA adducts by human DNA polymerase mu.Q44309847
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 geneQ45345090
Diploid yeast cells yield homozygous spontaneous mutations.Q46053570
Purification and enzymatic and functional characterization of DNA polymerase beta-like enzyme, POL4. expressed during yeast meiosisQ46412438
Purification and properties of wild-type and exonuclease-deficient DNA polymerase II from Escherichia coliQ46595699
Somatic hypermutation in the heavy chain locus correlates with transcriptionQ47713194
Molecular cloning, expression and chromosomal localisation of the mouse Rev3l gene, encoding the catalytic subunit of polymerase zetaQ47975722
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability.Q48033074
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.Q52163744
Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.Q52541355
New mutations affecting induced mutagenesis in yeast.Q52871941
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cellsQ53549666
Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta.Q54055057
Damage-repair error-prone polymerases of eubacteria: association with mobile genome elements.Q54541302
Recombination in adaptive mutation.Q54635736
DNA repair. The bases for Cockayne syndrome.Q55033948
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic HypermutationQ57198273
Position-specific codon conservation in hypervariable gene familiesQ57338763
Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA PolymeraseQ58424602
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment regionQ60370477
Pathways of ultraviolet mutability in Saccharomyces cerevisiae. II. The effect of rev genes on recombinationQ69965515
Terminal transferase: past to presentQ70259839
Somatic hypermutation of immunoglobulin genes is linked to transcription initiationQ70934062
Association of increased spontaneous mutation rates with high levels of transcription in yeastQ72304795
Excision repair and gene orientation modulate the strand specificity of UV mutagenesis in a plasmid-borne yeast tRNA geneQ72589153
Effect of umuC mutations on targeted and untargeted ultraviolet mutagenesis in bacteriophage λQ72820392
The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesisQ72994394
Alteration of ultraviolet-induced mutagenesis in yeast through molecular modulation of the REV3 and REV7 gene expressionQ73039820
Mismatch extension ability of yeast and human DNA polymerase etaQ73130869
Lesion bypass by the Escherichia coli DNA polymerase V requires assembly of a RecA nucleoprotein filamentQ73204355
Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitroQ73794379
Evidence for a second function for Saccharomyces cerevisiae Rev1pQ74130085
An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic deathQ74250699
Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domainQ74251724
Saccharomyces cerevisiae lacking Snm1, Rev3 or Rad51 have a normal S-phase but arrest permanently in G2 after cisplatin treatmentQ74297494
Mammalian base excision repair and DNA polymerase betaQ74754533
DNA polymerase lambda from calf thymus preferentially replicates damaged DNAQ77749013
Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutationQ77892518
EXO1 of Saccharomyces cerevisiae functions in mutagenesis during double-strand break repairQ78026677
Mammalian sperm proteins are rapidly evolving: evidence of positive selection in functionally diverse genesQ78461393
P407language of work or nameEnglishQ1860
P921main subjectgeneticsQ7162
P304page(s)31-66
P577publication date2003-01-01
P1433published inAnnual Review of GeneticsQ567358
P1476titleError-prone DNA polymerases: when making a mistake is the only way to get ahead
Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get Ahead
P478volume37

Reverse relations

cites work (P2860)
Q39839649A genomic island integrated into recA of Vibrio cholerae contains a divergent recA and provides multi-pathway protection from DNA damage
Q34059478A time-invariant principle of genome evolution
Q31109744Adaptive evolution by recombination is not associated with increased mutation rates in Maize streak virus
Q28478172An active site aromatic triad in Escherichia coli DNA Pol IV coordinates cell survival and mutagenesis in different DNA damaging agents
Q22122015An integrated view of protein evolution
Q35049451Analysis of the tolerance to DNA alkylating damage in MEC1 and RAD53 checkpoint mutants of Saccharomyces cerevisiae
Q36397932BapE DNA endonuclease induces an apoptotic-like response to DNA damage in Caulobacter
Q33604620Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates
Q34925302Biochemistry of eukaryotic homologous recombination
Q26827700Breaking bad: The mutagenic effect of DNA repair
Q59128454Constitutional mismatch repair-deficiency: current problems and emerging therapeutic strategies
Q28757270CpG dinucleotides and the mutation rate of non-CpG DNA
Q36193082DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation
Q36493831DNA repair in antibody somatic hypermutation
Q36751819DNA replication to aid somatic hypermutation
Q47293650DNA-repair potential of Halomonas spp. from the Salt Plains Microbial Observatory of Oklahoma
Q35002361Damage-induced localized hypermutability.
Q54429900Ectopic gene conversions in bacterial genomes.
Q39673476Effect of human cell malignancy on activity of DNA polymerase ι
Q39294162Emerging roles for histone modifications in DNA excision repair
Q46964025Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone
Q35017866Escherichia coli YafP protein modulates DNA damaging property of the nitroaromatic compounds
Q36391958Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae
Q24796773Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
Q64234772Evolutionary Origins of Pseudogenes and Their Association with Regulatory Sequences in Plants
Q33334428Highly conserved regimes of neighbor-base-dependent mutation generated the background primary-structural heterogeneities along vertebrate chromosomes
Q33273825Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.
Q42126464Involvement of Escherichia coli DNA polymerase IV in tolerance of cytotoxic alkylating DNA lesions in vivo.
Q37052306Long-term effects of inducible mutagenic DNA repair on relative fitness and phenotypic diversification in Pseudomonas cichorii 302959.
Q36369839Long-term survival during stationary phase: evolution and the GASP phenotype
Q36753339Mechanisms of disease: DNA repair defects and neurological disease
Q34629238Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain
Q90004212Mimivirus encodes a multifunctional primase with DNA/RNA polymerase, terminal transferase and translesion synthesis activities
Q35842713Multiple solutions to inefficient lesion bypass by T7 DNA polymerase.
Q34504886Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break
Q36836977Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae
Q103806007Mutation-selection balance and compensatory mechanisms in tumour evolution
Q47747085NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro.
Q44246963Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta
Q36687820Plant responses to UV radiation and links to pathogen resistance.
Q36960224Potential role of meiosis proteins in melanoma chromosomal instability
Q46751740Pre-steady-state kinetic characterization of the DinB homologue DNA polymerase of Sulfolobus solfataricus
Q43726885Protein insertions and deletions enabled by neutral roaming in sequence space
Q36685881Recombination: an underappreciated factor in the evolution of plant genomes
Q42407123Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast
Q37294797Somatic microindels in human cancer: the insertions are highly error-prone and derive from nearby but not adjacent sense and antisense templates
Q46287722Structure-function analysis of the barley genome: the gene-rich region of chromosome 2HL.
Q36337954Suffering in silence: the tolerance of DNA damage
Q44577322Suppression of SOS repair in E. coli: possible mechanism of antimutagenicity and protective effects of common vegetables
Q55073069Synthesis and biochemical characterization of tricyclothymidine triphosphate (tc-TTP).
Q51215555Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.
Q27931291The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae
Q56926775The UV responses of bacterioneuston and bacterioplankton isolates depend on the physiological condition and involve a metabolic shift
Q33526473The contribution of recombination to heterozygosity differs among plant evolutionary lineages and life-forms.
Q27934540The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesis
Q37153771The mismatch repair system promotes DNA polymerase zeta-dependent translesion synthesis in yeast.
Q28586941The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm
Q35062343The pattern of DNA cleavage intensity around indels
Q39642875Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis
Q33282474Transcription-related mutations and GC content drive variation in nucleotide substitution rates across the genomes of Arabidopsis thaliana and Arabidopsis lyrata
Q46087063Understanding the interaction between an obligate hyperparasitic bacterium, Pasteuria penetrans and its obligate plant-parasitic nematode host, Meloidogyne spp.
Q41496563Variants of sequence family B Thermococcus kodakaraensis DNA polymerase with increased mismatch extension selectivity
Q37444742Y-family DNA polymerases in mammalian cells

Search more.