review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1016/S1383-5742(99)00003-4 |
P698 | PubMed publication ID | 10095138 |
P2093 | author name string | N Maizels | |
Q Kong | |||
R S Harris | |||
P2860 | cites work | Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene | Q24312723 |
A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta | Q24323043 | ||
Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation | Q24323094 | ||
A phylogenomic study of the MutS family of proteins | Q24548238 | ||
Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma | Q24561494 | ||
Adaptive mutation: the uses of adversity | Q24596056 | ||
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes | Q24652779 | ||
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease | Q24682616 | ||
Deoxycytidyl transferase activity of yeast REV1 protein | Q27931173 | ||
Thymine-thymine dimer bypass by yeast DNA polymerase zeta | Q27938043 | ||
Genes and antibodies | Q28185156 | ||
Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes | Q28235330 | ||
LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas | Q28255448 | ||
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma | Q28256118 | ||
Stimulation by Rad52 of yeast Rad51-mediated recombination | Q28260489 | ||
Conformations of immunoglobulin hypervariable regions | Q28273335 | ||
Biochemistry and genetics of eukaryotic mismatch repair | Q28282377 | ||
Sequence analysis and expression of a novel mouse homolog of Escherichia coli recA gene | Q47874682 | ||
Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase | Q47901855 | ||
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes | Q47982616 | ||
Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase | Q48037871 | ||
Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants | Q48061718 | ||
Locus-specific somatic hypermutation in germinal centre T cells | Q48077130 | ||
Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene | Q48079225 | ||
The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron | Q48081907 | ||
Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes | Q48085081 | ||
Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches | Q48232702 | ||
Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice | Q48348716 | ||
A hyperconversion mechanism generates the chicken light chain preimmune repertoire | Q48349399 | ||
Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma | Q48394120 | ||
Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene | Q48398045 | ||
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody | Q48409127 | ||
Somatic mutation of immunoglobulin light-chain variable-region genes | Q48409137 | ||
The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription. | Q50111104 | ||
Synergistic actions of Rad51 and Rad52 in recombination and DNA repair | Q50335533 | ||
Antigen-specific development of primary and memory T cells in vivo. | Q52053475 | ||
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. | Q52524907 | ||
Variability in the Lambda Light Chain Sequences of Mouse Antibody | Q52832029 | ||
A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli. | Q54567733 | ||
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. | Q54608320 | ||
Adaptive mutation by deletions in small mononucleotide repeats. | Q54630365 | ||
Recombination in adaptive mutation. | Q54635736 | ||
Somatic hypermutagenesis in immunoglobulin genes. III. Somatic mutations in the chicken light chain locus | Q58003468 | ||
Origin of Antibody Variation | Q59057486 | ||
Codon bias targets mutation. | Q59081204 | ||
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region | Q60370477 | ||
Monitoring and interpreting the intrinsic features of somatic hypermutation | Q61628475 | ||
Recombination-based mechanisms for somatic hypermutation | Q64389096 | ||
Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region | Q69235085 | ||
Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice | Q69868150 | ||
Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment | Q70320281 | ||
Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer | Q70608716 | ||
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation | Q70934062 | ||
Somatic mutation of immunoglobulin V genes in vitro | Q71095985 | ||
Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D) | Q71163077 | ||
Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site-specific abasic lesion | Q71265026 | ||
Strategies for expressing human antibody repertoires in transgenic mice | Q71475348 | ||
Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process | Q72388464 | ||
Somatic mutation. From the dark zone to the light | Q72707873 | ||
Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation | Q73689109 | ||
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes | Q73864520 | ||
Somatic hypermutation, transcription, and DNA mismatch repair | Q77198198 | ||
DNA repair: knockouts still mutating after first round | Q77502682 | ||
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer | Q28294774 | ||
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein | Q28505917 | ||
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting | Q28506440 | ||
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process | Q28507129 | ||
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice | Q28507519 | ||
Rad51 expression and localization in B cells carrying out class switch recombination | Q28508346 | ||
MSH2 deficient mice are viable and susceptible to lymphoid tumours | Q28508486 | ||
Mammalian Rad51 protein: a RecA homologue with pleiotropic functions | Q28611458 | ||
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 | Q28910215 | ||
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours | Q29547697 | ||
Mismatch repair in replication fidelity, genetic recombination, and cancer biology | Q29616483 | ||
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice | Q29618278 | ||
DNA excision repair | Q29618453 | ||
Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene | Q30054509 | ||
Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta. | Q32060399 | ||
Analysis of damage tolerance pathways in Saccharomyces cerevisiae: a requirement for Rev3 DNA polymerase in translesion synthesis | Q33771455 | ||
Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation | Q33886793 | ||
Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. | Q33886982 | ||
Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli. | Q34019746 | ||
Induction of somatic mutation in a human B cell line in vitro | Q34418234 | ||
RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange | Q34466769 | ||
Mismatch repair protein MutL becomes limiting during stationary-phase mutation | Q35190848 | ||
Defining the nucleic acid substrate for somatic hypermutation | Q35380853 | ||
Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis | Q35606437 | ||
Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation | Q35939989 | ||
V(D)J hypermutation and DNA mismatch repair: vexed by fixation | Q36066595 | ||
Skiing the black diamond slope: progress on the biochemistry of translesion DNA synthesis | Q36072617 | ||
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots | Q36172034 | ||
Both DNA strands of antibody genes are hypermutation targets | Q36220380 | ||
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci | Q36322298 | ||
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene | Q36354162 | ||
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus | Q36376764 | ||
B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes | Q36380439 | ||
Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers | Q36380783 | ||
The role of DNA repair in somatic hypermutation of immunoglobulin genes | Q36400909 | ||
Mechanisms and biological effects of mismatch repair | Q37041860 | ||
Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion | Q37357847 | ||
Somatic mutation in constant regions of mouse lambda 1 light chains | Q37591443 | ||
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis | Q38293261 | ||
Mutation drift and repertoire shift in the maturation of the immune response | Q39658890 | ||
Measurements of mutation rates in B lymphocytes. | Q39658912 | ||
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice | Q39720046 | ||
Somatic hypermutation | Q40404787 | ||
Somatic hypermutation: how many mechanisms diversify V region sequences? | Q40410605 | ||
Antigenic variation in malaria | Q40442253 | ||
Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans | Q40522942 | ||
Targeting and regulation of immunoglobulin gene somatic hypermutation and isotype switch recombination | Q40527478 | ||
Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes | Q40696088 | ||
Linear DNA of Borrelia species and antigenic variation | Q40713853 | ||
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes | Q40858318 | ||
Homologous recombination and the roles of double-strand breaks | Q40930013 | ||
Somatic hypermutation of immunoglobulin genes | Q40955728 | ||
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line | Q40982321 | ||
The molecular basis of somatic hypermutation of immunoglobulin genes | Q41049026 | ||
Gene conversion and homologous recombination in murine B cells | Q41062373 | ||
The germinal center: a crucible for lymphocyte selection | Q41062392 | ||
Rearrangement/hypermutation/gene conversion: when, where and why? | Q41113095 | ||
Intraclonal generation of antibody mutants in germinal centres | Q41172275 | ||
A quasi-monoclonal mouse | Q41192055 | ||
Enhancers of hypermutation | Q41246318 | ||
Meiotic recombination in yeast: coronation of the double-strand-break repair model | Q41285976 | ||
The VH and CH immunoglobulin genes of swine: implications for repertoire development. | Q41299754 | ||
The origins of V(D)J recombination | Q41329165 | ||
Generation of antibody diversity in rabbits | Q41429681 | ||
DNA excision repair pathways | Q41441658 | ||
DNA turnover and mutation in resting cells | Q41459470 | ||
Accessibility and the developmental regulation of V(D)J recombination | Q41512946 | ||
Immunoglobulin gene diversification in cattle | Q41531157 | ||
DNA glycosylases in the base excision repair of DNA | Q41532551 | ||
Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs | Q41572901 | ||
Nucleotide excision repair in mammalian cells | Q41593250 | ||
Mutation for survival | Q41703503 | ||
Comparison of somatic mutation frequency among immunoglobulin genes | Q42248453 | ||
Evolution of somatic hypermutation and gene conversion in adaptive immunity | Q42678194 | ||
Mismatch repair co-opted by hypermutation. | Q43917262 | ||
Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits | Q44370457 | ||
Antigen receptor gene rearrangement | Q46107069 | ||
Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice | Q46760824 | ||
Somatic hypermutation in the heavy chain locus correlates with transcription | Q47713194 | ||
Role of the human RAD51 protein in homologous recombination and double-stranded-break repair | Q47714499 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 157-178 | |
P577 | publication date | 1999-03-01 | |
P1433 | published in | Mutation Research | Q6943732 |
P1476 | title | Somatic hypermutation and the three R's: repair, replication and recombination | |
P478 | volume | 436 |
Q36097067 | Analysis of the Par2 modifier of pulmonary adenoma formation in mice |
Q40783328 | Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line |
Q48646543 | Coevolution of quasispecies: B-cell mutation rates maximize viral error catastrophes |
Q34612364 | DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation |
Q24523653 | DNA polymerase iota and related rad30-like enzymes |
Q73406613 | DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae |
Q77967011 | DNA repair: Polymerases for passing lesions |
Q35208627 | Double-strand-break repair recombination in Escherichia coli: physical evidence for a DNA replication mechanism in vivo |
Q36238936 | Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines |
Q35582961 | Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get Ahead |
Q36368573 | Error-prone candidates vie for somatic mutation |
Q34609122 | Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination |
Q34094904 | Evolutionary changes in mutation rates and spectra and their influence on the adaptation of pathogens |
Q34297067 | Evolving responsively: adaptive mutation |
Q28652092 | Exome-wide somatic microsatellite variation is altered in cells with DNA repair deficiencies |
Q36533627 | Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation |
Q47618103 | Hidden variables: unstable Abeta chain genes encoding antigen recognition structures in tumor survivors |
Q33594913 | Immunoglobulin class switch recombination: will genetics provide new clues to mechanism? |
Q35037445 | In pursuit of a molecular mechanism for adaptive gene amplification |
Q36037736 | Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences |
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Q53601817 | Naïve Human Antibody Libraries for Infectious Diseases. |
Q39455619 | Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota |
Q33885007 | Sloppier copier DNA polymerases involved in genome repair |
Q28510640 | Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern |
Q34516540 | Somatic hypermutation in human B cell subsets |
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Q35544150 | Stationary phase mutagenesis: mechanisms that accelerate adaptation of microbial populations under environmental stress |
Q37096423 | Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependence |
Q47655848 | Stress-induced cellular adaptive strategies: ancient evolutionarily conserved programs as new anticancer therapeutic targets. |
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