| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1074-7613(00)80651-2 |
| P698 | PubMed publication ID | 9881976 |
| P50 | author | Julian E Sale | Q40247762 |
| P2093 | author name string | Neuberger MS | |
| P2860 | cites work | Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes | Q24652779 |
| Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease | Q24682616 | ||
| Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein | Q28505917 | ||
| Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting | Q28506440 | ||
| Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process | Q28507129 | ||
| Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice | Q28507519 | ||
| An immunoglobulin mutator that targets G.C base pairs | Q33584295 | ||
| Induction of somatic mutation in a human B cell line in vitro | Q34418234 | ||
| Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases | Q36070698 | ||
| Both DNA strands of antibody genes are hypermutation targets | Q36220380 | ||
| Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin | Q36261566 | ||
| Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions | Q36302303 | ||
| Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells | Q36565828 | ||
| Antibody diversity: somatic hypermutation of rearranged VH genes | Q36587415 | ||
| Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome | Q36664862 | ||
| Clonal evolution of a follicular lymphoma: evidence for antigen selection | Q37120876 | ||
| Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice | Q37275566 | ||
| Rate of somatic mutation in immunoglobulin production by mouse myeloma cells | Q37548685 | ||
| Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line | Q37675025 | ||
| The dynamic nature of the antibody repertoire | Q39545231 | ||
| Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice | Q39720046 | ||
| Molecular analysis of spontaneous somatic mutants | Q39859448 | ||
| An EBV-Genome-Negative Cell Line Established from an American Burkitt Lymphoma; Receptor Characteristics. EBV Infectibility and Permanent Conversion into EBV-Positive Sublines by <i>in vitro</i> Infection | Q40001995 | ||
| A new DNA sequence assembly program | Q40397097 | ||
| Somatic hypermutation | Q40404787 | ||
| Somatic hypermutation: how many mechanisms diversify V region sequences? | Q40410605 | ||
| Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes | Q40858318 | ||
| The targeting of somatic hypermutation | Q41062380 | ||
| Rearrangement/hypermutation/gene conversion: when, where and why? | Q41113095 | ||
| A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro | Q41264930 | ||
| The Somatic Hypermutation Activity of a Follicular Lymphoma Links to Large Insertions and Deletions of Immunoglobulin Genes | Q41329806 | ||
| A reporter gene to analyse the hypermutation of immunoglobulin genes. | Q41335610 | ||
| Rapid cloning of rearranged immunoglobulin heavy chain genes from human B-cell lines using anchored polymerase chain reaction | Q41639953 | ||
| Analysis of the kappa light chain variable region in multiple myeloma | Q42636552 | ||
| Evolution of somatic hypermutation and gene conversion in adaptive immunity | Q42678194 | ||
| Mutation, selection, and memory in B lymphocytes of exothermic vertebrates | Q46898159 | ||
| Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism. | Q52902753 | ||
| A table for the estimation of the spontaneous mutations rate of cells in culture | Q52957251 | ||
| Codon bias targets mutation. | Q59081204 | ||
| Immunoglobulin hypermutation in cultured cells | Q60168858 | ||
| Recombination-based mechanisms for somatic hypermutation | Q64389096 | ||
| Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D) | Q71163077 | ||
| Introduction: what mechanism(s) drive hypermutation? | Q71342828 | ||
| Strand breaks in immunoglobulin gene hypermutation | Q73423436 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 859-869 | |
| P577 | publication date | 1998-12-01 | |
| P1433 | published in | Immunity | Q6005457 |
| P1476 | title | TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line | |
| P478 | volume | 9 |
| Q35119929 | A Modified Digestion‐Circularization PCR (DC‐PCR) Approach to Detect Hypermutation‐Associated DNA Double‐Strand Breaks |
| Q33398520 | A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation |
| Q33770275 | A new class of errant DNA polymerases provides candidates for somatic hypermutation |
| Q36229681 | A role for AID in chromosome translocations between c-myc and the IgH variable region. |
| Q34133261 | A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation |
| Q36229591 | A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification |
| Q34770418 | AID and mismatch repair in antibody diversification |
| Q42813803 | AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts |
| Q28366125 | AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching |
| Q28208979 | AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification |
| Q35068183 | AID to overcome the limitations of genomic information by introducing somatic DNA alterations |
| Q24531345 | AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization |
| Q41771550 | AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation |
| Q40714843 | AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line |
| Q36173942 | AIDing antibody diversity by error-prone mismatch repair |
| Q36979845 | Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells |
| Q40782991 | Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation |
| Q28217205 | Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas |
| Q37325284 | Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line |
| Q40566152 | Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks |
| Q42944652 | Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation |
| Q46485635 | Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis |
| Q24535441 | Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template. |
| Q37052624 | Antibody diversification by somatic mutation: from Burnet onwards |
| Q36604773 | Antibody diversification: mutational mechanisms and oncogenesis |
| Q34085570 | Antibody diversity: a link between switching and hypermutation |
| Q36887122 | Antigen receptor diversification and chromosome translocations |
| Q39443203 | Assessing somatic hypermutation in Ramos B cells after overexpression or knockdown of specific genes |
| Q24642971 | Association of terminal deoxynucleotidyl transferase with Ku |
| Q24303987 | Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression |
| Q34748194 | B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity |
| Q35549146 | B cells under influence: transformation of B cells by Epstein–Barr virus |
| Q40377462 | BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells |
| Q40329923 | Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells |
| Q43442944 | By-products of immunoglobulin somatic hypermutation |
| Q35768862 | Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID. |
| Q40840741 | Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes |
| Q38594084 | Checkpoint kinase 1 negatively regulates somatic hypermutation |
| Q42541714 | Checkpoint kinase 2 is required for efficient immunoglobulin diversification |
| Q52128463 | Chromosomal translocation master genes, mouse models and experimental therapeutics. |
| Q40783328 | Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line |
| Q34096649 | Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies |
| Q64388100 | DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways |
| Q57198273 | DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation |
| Q34612364 | DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation |
| Q36405094 | DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis |
| Q36015019 | DNA deamination in immunity |
| Q42944715 | DNA double-strand breaks: prior to but not sufficient in targeting hypermutation |
| Q36193082 | DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation |
| Q28190856 | DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes |
| Q40410915 | DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells |
| Q33770300 | DNA polymerase mu, a candidate hypermutase? |
| Q37109944 | DNA polymerases in adaptive immunity |
| Q42676262 | Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. |
| Q36228903 | Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. |
| Q35828141 | Directed evolution of human scFvs in DT40 cells. |
| Q41892816 | Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation |
| Q55208667 | Diversity in the Cow Ultralong CDR H3 Antibody Repertoire. |
| Q57307991 | Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes |
| Q34572184 | Emerging links between hypermutation of antibody genes and DNA polymerases |
| Q39604795 | Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells |
| Q34222332 | Error-Prone DNA Repair Activity during Somatic Hypermutation in Shark B Lymphocytes |
| Q36368573 | Error-prone candidates vie for somatic mutation |
| Q30882543 | Estimating Hypermutation Rates from Clonal Tree Data |
| Q37061875 | Estrogen directly activates AID transcription and function |
| Q36389685 | Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair |
| Q34155308 | Evolution and the molecular basis of somatic hypermutation of antigen receptor genes |
| Q37627375 | Evolution of new nonantibody proteins via iterative somatic hypermutation. |
| Q40150046 | Evolving proteins in mammalian cells using somatic hypermutation |
| Q36533627 | Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation |
| Q36906733 | GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy |
| Q40697370 | Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines |
| Q33404063 | Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes |
| Q33853276 | Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase |
| Q37022515 | High-fidelity correction of genomic uracil by human mismatch repair activities |
| Q91936482 | High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes |
| Q33641304 | Histone H2A and H2B are monoubiquitinated at AID-targeted loci. |
| Q24645030 | HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation |
| Q52582141 | Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells. |
| Q35671715 | Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (hyper-IgM syndromes). |
| Q42674915 | Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions |
| Q53665463 | Hypothesis: biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation. |
| Q40022115 | Identification of genes deregulated during serum-free medium adaptation of a Burkitt's lymphoma cell line |
| Q37164431 | Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues |
| Q34700410 | Ig gene hypermutation: a mechanism is due. |
| Q44194766 | Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice |
| Q35213276 | Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair |
| Q34155290 | In vivo and in vitro studies of immunoglobulin gene somatic hypermutation |
| Q42125185 | Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes |
| Q34157224 | Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. |
| Q40625542 | Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin |
| Q36037742 | Isoforms of terminal deoxynucleotidyltransferase: developmental aspects and function |
| Q88293192 | JH6 downstream intronic sequence is dispensable for RNA polymerase II accumulation and somatic hypermutation of the variable gene in Ramos cells |
| Q33695334 | Lineage specificity of gene expression patterns |
| Q34297090 | Linking class-switch recombination with somatic hypermutation |
| Q34500935 | Mechanism and control of class-switch recombination |
| Q24676321 | Memory in the B-cell compartment: antibody affinity maturation |
| Q28592782 | Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally |
| Q34542246 | Molecular mechanism of class switch recombination: linkage with somatic hypermutation |
| Q36622615 | Molecular pathways in follicular lymphoma. |
| Q48292333 | Mutation detection of immunoglobulin V-regions by DHPLC. |
| Q40240123 | Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination |
| Q34580389 | Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies |
| Q40405554 | Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate |
| Q35128767 | Overlapping hotspots in CDRs are critical sites for V region diversification |
| Q42441367 | Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses. |
| Q40150418 | Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription |
| Q28586777 | Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts |
| Q33904476 | Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes |
| Q35305645 | Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells |
| Q27000758 | Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination |
| Q33989467 | Repression of human activation induced cytidine deaminase by miR-93 and miR-155. |
| Q61814105 | Reprogramming the antigen specificity of B cells using genome-editing technologies |
| Q52431678 | SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation. |
| Q28270934 | Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair |
| Q73024051 | Signals sustaining human immunoglobulin V gene hypermutation in isolated germinal centre B cells |
| Q24307502 | Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase |
| Q73256864 | Somatic evolution of antibody specificity: setting the clock forward |
| Q34155314 | Somatic hypermutation and B-cell lymphoma |
| Q33545735 | Somatic hypermutation and the three R's: repair, replication and recombination |
| Q28510640 | Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern |
| Q34516540 | Somatic hypermutation in human B cell subsets |
| Q42944177 | Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity |
| Q34619789 | Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity |
| Q34116350 | Somatic immunoglobulin hypermutation |
| Q34491046 | Systemic lupus erythematosus and B-cell hematologic neoplasm |
| Q44771096 | T cell-independent somatic hypermutation in murine B cells with an immature phenotype |
| Q36845667 | Targeting of AID-mediated sequence diversification by cis-acting determinants |
| Q37824444 | Technologies of directed protein evolution in vivo. |
| Q36280649 | Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells |
| Q24319096 | The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells |
| Q40413218 | The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions |
| Q42944711 | The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process |
| Q74083363 | The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line |
| Q36370158 | The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks |
| Q39645618 | The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially |
| Q35597111 | The mechanisms of immune diversification and their disorders |
| Q45224261 | The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung(-/-)msh2(-/-) mice |
| Q34414672 | The occurrence and significance of V gene mutations in B cell-derived human malignancy |
| Q38041514 | The role of activation-induced deaminase in antibody diversification and genomic instability |
| Q34616322 | The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae |
| Q36248087 | The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation. |
| Q37325287 | Timing matters: error-prone gap filling and translesion synthesis in immunoglobulin gene hypermutation |
| Q32067279 | Towards an understanding of somatic hypermutation |
| Q40646599 | Transcript expression of two Iglambda rearrangements and RAG-1/RAG-2 in a mature human B cell producing IgMlambda islet cell autoantibody. |
| Q91844697 | Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting |
| Q33770295 | Transcription, beta-like DNA polymerases and hypermutation |
| Q40307619 | Tumor necrosis factor-alpha and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells |
| Q24290234 | Two novel human and mouse DNA polymerases of the polX family |
| Q35164207 | What role for AID: mutator, or assembler of the immunoglobulin mutasome? |
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