Recombination-based mechanisms for somatic hypermutation

scientific article published on 01 April 1998

Recombination-based mechanisms for somatic hypermutation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1600-065X.1998.TB01430.X
P698PubMed publication ID9602353

P2093author name stringN Maizels
Q Kong
R S Harris
P2860cites workElevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2Q22248073
Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locusQ27930817
The double-strand-break repair model for recombinationQ28267259
Conformations of immunoglobulin hypervariable regionsQ28273335
Somatic mutation. From the dark zone to the lightQ72707873
Preimmune diversification creates a repertoire while somatic hypermutation fine-tunes affinity--implications for the processes of mutationQ72761221
Evidence for a physical interaction between the transposed and the substituted sequences during mating type gene transposition in yeastQ72867871
Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutationQ73689109
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genesQ73864520
Nuclear Rad51 foci induced by DNA damage are distinct from Rad51 foci associated with B cell activation and recombinationQ74000210
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overQ28282791
The origin of mutantsQ28288915
Rad51 expression and localization in B cells carrying out class switch recombinationQ28508346
Targeted disruption of the Rad51 gene leads to lethality in embryonic miceQ29618278
Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutationQ33886793
Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loopQ34398630
Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutationQ35939989
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J geneQ36354162
Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodiesQ36354592
Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitisQ36361154
B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genesQ36380439
Antibody diversity: somatic hypermutation of rearranged VH genesQ36587415
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable regionQ36630020
The split-end model for homologous recombination at double-strand breaks and at Chi.Q37361171
Role of recombination enzymes in mammalian cell survivalQ37508951
Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?Q38622353
Sequences of mouse immunoglobulin light chain genes before and after somatic changesQ39638807
Gene conversion: some implications for immunoglobulin genesQ40309212
Somatic hypermutation: how many mechanisms diversify V region sequences?Q40410605
Where transcription meets repairQ40739628
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genesQ40858318
Homologous recombination and the roles of double-strand breaksQ40930013
Somatic hypermutation of immunoglobulin genesQ40955728
The mechanism of somatic hypermutation studied with transgenic and transfected target genesQ41062365
Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approachesQ41062370
Gene conversion and homologous recombination in murine B cellsQ41062373
The targeting of somatic hypermutationQ41062380
The germinal center: a crucible for lymphocyte selectionQ41062392
Rearrangement/hypermutation/gene conversion: when, where and why?Q41113095
Genetic barriers among bacteria.Q41120565
Intraclonal generation of antibody mutants in germinal centresQ41172275
Meiotic recombination in yeast: coronation of the double-strand-break repair modelQ41285976
Generation of antibody diversity in rabbitsQ41429681
Mutation for survivalQ41703503
Distribution of mutations around rearranged heavy-chain antibody variable-region genesQ41966971
Comparison of somatic mutation frequency among immunoglobulin genesQ42248453
Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genesQ48085081
A hyperconversion mechanism generates the chicken light chain preimmune repertoireQ48349399
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibodyQ48409127
Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanismQ48409267
The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutantsQ50192890
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.Q54419614
Microbial genetics. Hypermutation under stress.Q54564293
A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli.Q54567733
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.Q54608320
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment regionQ60370477
Somatic hypermutation of immunoglobulin genes is linked to transcription initiationQ70934062
The appendix functions as a mammalian bursal equivalent in the developing rabbitQ72140518
P407language of work or nameEnglishQ1860
P304page(s)67-76
P577publication date1998-04-01
P1433published inImmunological ReviewsQ15724582
P1476titleRecombination-based mechanisms for somatic hypermutation
P478volume162

Reverse relations

cites work (P2860)
Q34094904Evolutionary changes in mutation rates and spectra and their influence on the adaptation of pathogens
Q35213276Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair
Q33545735Somatic hypermutation and the three R's: repair, replication and recombination
Q40982321TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
Q92963126The KT Jeang Prize 2019: Reuben S. Harris : Romancing the Mutator

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