Distribution of mutations around rearranged heavy-chain antibody variable-region genes

scientific article published on October 1990

Distribution of mutations around rearranged heavy-chain antibody variable-region genes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.10.10.5187
P932PMC publication ID361197
P698PubMed publication ID2118991
P5875ResearchGate publication ID21037024

P2093author name stringPollard JW
Steele EJ
Taylor L
Both GW
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymeraseQ26778389
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinasesQ33390878
Patterns of somatic mutations in immunoglobulin variable genesQ33952719
Fidelity of DNA polymerases in DNA amplificationQ34322626
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymeraseQ34556300
A promoterless retroviral vector indicates that there are sequences in U3 required for 3' RNA processingQ34599447
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversityQ35311377
Structure of the 5' ends of immunoglobulin genes: a novel conserved sequenceQ36258756
Antibody diversity: somatic hypermutation of rearranged VH genesQ36587415
Clusters of point mutations are found exclusively around rearranged antibody variable genesQ36593569
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable regionQ36630020
Retroviral vector system for the study of cDNA gene formationQ36789886
Mutational analysis of the immunoglobulin heavy chain promoter regionQ37411997
Serotype-specific glycoprotein of simian 11 rotavirus: coding assignment and gene sequenceQ37612462
Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?Q38622353
Exonucleolytic proofreadingQ39223003
Palindromic sequences are associated with sites of DNA breakage during gene conversionQ40561631
Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chainsQ41337845
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.Q41380981
Molecular basis of an isogeneic anti-idiotypic response.Q41586815
Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NPQ42573237
Antibody engineering for the analysis of affinity maturation of an anti-hapten response.Q42735546
The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouseQ43657127
Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptaseQ46193418
Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responsesQ48348065
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain geneQ48397674
Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V geneQ48398045
Somatic mutation of immunoglobulin light-chain variable-region genesQ48409137
Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanismQ48409267
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genesQ48412817
Origin of Antibody VariationQ59057486
Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elementsQ59070373
Mechanism of antigen-driven selection in germinal centresQ59072211
V gene rearrangement is required to fully activate the hypermutation mechanism in B cellsQ69174827
Genetic noise in evolution?Q72723470
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)5187-5196
P577publication date1990-10-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDistribution of mutations around rearranged heavy-chain antibody variable-region genes
P478volume10

Reverse relations

cites work (P2860)
Q41264930A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro
Q48081204A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation
Q47771685A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes
Q34505084A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.
Q41839580Acquisition of Genetic Aberrations by Activation-Induced Cytidine Deaminase (AID) during Inflammation-Associated Carcinogenesis
Q37994933Activation-induced cytidine deaminase in antibody diversification and chromosome translocation
Q40801731Affinity maturation of lymphocyte receptors and positive selection of T cells in the thymus
Q33584295An immunoglobulin mutator that targets G.C base pairs
Q33391280Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications
Q34328629Analysis of somatic mutation in five B cell subsets of human tonsil
Q45872648Autologous T lymphocytes recognize the tumour-derived immunoglobulin VH-CDR3 region in patients with B-cell chronic lymphocytic leukaemia
Q38506144Chromatin domains and prediction of MAR sequences.
Q37120876Clonal evolution of a follicular lymphoma: evidence for antigen selection
Q37385073Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.
Q42248453Comparison of somatic mutation frequency among immunoglobulin genes
Q35851102Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines
Q33622342Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?
Q36616139Effect of Helicobacter pylori eradication on ongoing mutation of immunoglobulin genes in gastric MALT lymphoma
Q57307991Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes
Q34063681Elucidation of IgH intronic enhancer functions via germ-line deletion
Q40696086Generating the antibody repertoire in rabbit.
Q34310757Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes
Q33960151Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies
Q34310763Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
Q36361415Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation
Q28507519Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
Q38318053Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24.
Q53665463Hypothesis: biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation.
Q48037871Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase
Q34114760Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line
Q36362440In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
Q40802589In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains
Q33237877Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies
Q88293192JH6 downstream intronic sequence is dispensable for RNA polymerase II accumulation and somatic hypermutation of the variable gene in Ramos cells
Q40983825Life and death in germinal centers (redux).
Q37255156Ligation-anchored PCR: a simple amplification technique with single-sided specificity
Q41359348Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse
Q40505615Mechanisms of antigenic variation in Borrelia hermsii and African trypanosomes
Q35939989Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
Q37587941Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response
Q37525213Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes
Q41083928Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication
Q35953749On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes
Q72875088Origin and maintenance of germ-line V genes
Q45025354PCR amplification of murine immunoglobulin germline V genes: strategies for minimization of recombination artefacts
Q46279727PIWIs, piRNAs and Retrotransposons: Complex battles during reprogramming in gametes and early embryos
Q36172034Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots
Q44870111Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection
Q28087424RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome
Q39720046Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice
Q47996615Recombination signature of germline immunoglobulin variable genes
Q64389096Recombination-based mechanisms for somatic hypermutation
Q47108323Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory
Q57295484Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
Q34468679Soma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC: The manifest polymorphism of the MHC appears greatly exceeded at Immunoglobulin loci, suggesting antigen-selected somatic V mutants penetrate Weismann's Barrie
Q41222940Somatic diversification of antibody responses
Q48103170Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions
Q24652779Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes
Q36399510Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase
Q36361238Somatic hypermutation of an immunoglobulin mu heavy chain transgene
Q70934062Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
Q41081725Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.
Q34922043Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).
Q33367730Somatic hypermutation: Another piece in the hypermutation puzzle
Q55034838Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.
Q37591443Somatic mutation in constant regions of mouse lambda 1 light chains
Q40771425Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression
Q40527478Targeting and regulation of immunoglobulin gene somatic hypermutation and isotype switch recombination
Q54608320Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.
Q48081907The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron
Q50111104The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription.
Q35734132The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes
Q39645618The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
Q41049026The molecular basis of somatic hypermutation of immunoglobulin genes
Q33770284The reverse transcriptase model of somatic hypermutation
Q28592120The specificity and orientation of a TCR to its peptide-MHC class II ligands
Q28190690Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
Q42799816Variable region gene selection of immunoglobulin G‐expressing B cells with specificity for a defined epitope on type II collagen
Q35219287c-mycHypermutation in Burkitt's Lymphoma