scholarly article | Q13442814 |
P2093 | author name string | Pollard JW | |
Steele EJ | |||
Taylor L | |||
Both GW | |||
P2860 | cites work | DNA sequencing with chain-terminating inhibitors | Q22066207 |
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase | Q26778389 | ||
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease | Q26778460 | ||
Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases | Q33390878 | ||
Patterns of somatic mutations in immunoglobulin variable genes | Q33952719 | ||
Fidelity of DNA polymerases in DNA amplification | Q34322626 | ||
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase | Q34556300 | ||
A promoterless retroviral vector indicates that there are sequences in U3 required for 3' RNA processing | Q34599447 | ||
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity | Q35311377 | ||
Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence | Q36258756 | ||
Antibody diversity: somatic hypermutation of rearranged VH genes | Q36587415 | ||
Clusters of point mutations are found exclusively around rearranged antibody variable genes | Q36593569 | ||
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region | Q36630020 | ||
Retroviral vector system for the study of cDNA gene formation | Q36789886 | ||
Mutational analysis of the immunoglobulin heavy chain promoter region | Q37411997 | ||
Serotype-specific glycoprotein of simian 11 rotavirus: coding assignment and gene sequence | Q37612462 | ||
Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes? | Q38622353 | ||
Exonucleolytic proofreading | Q39223003 | ||
Palindromic sequences are associated with sites of DNA breakage during gene conversion | Q40561631 | ||
Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains | Q41337845 | ||
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. | Q41380981 | ||
Molecular basis of an isogeneic anti-idiotypic response. | Q41586815 | ||
Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP | Q42573237 | ||
Antibody engineering for the analysis of affinity maturation of an anti-hapten response. | Q42735546 | ||
The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse | Q43657127 | ||
Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase | Q46193418 | ||
Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses | Q48348065 | ||
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene | Q48397674 | ||
Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene | Q48398045 | ||
Somatic mutation of immunoglobulin light-chain variable-region genes | Q48409137 | ||
Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism | Q48409267 | ||
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes | Q48412817 | ||
Origin of Antibody Variation | Q59057486 | ||
Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements | Q59070373 | ||
Mechanism of antigen-driven selection in germinal centres | Q59072211 | ||
V gene rearrangement is required to fully activate the hypermutation mechanism in B cells | Q69174827 | ||
Genetic noise in evolution? | Q72723470 | ||
P433 | issue | 10 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | antibody | Q79460 |
P304 | page(s) | 5187-5196 | |
P577 | publication date | 1990-10-01 | |
P1433 | published in | Molecular and Cellular Biology | Q3319478 |
P1476 | title | Distribution of mutations around rearranged heavy-chain antibody variable-region genes | |
P478 | volume | 10 |
Q41264930 | A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro |
Q48081204 | A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation |
Q47771685 | A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes |
Q34505084 | A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. |
Q41839580 | Acquisition of Genetic Aberrations by Activation-Induced Cytidine Deaminase (AID) during Inflammation-Associated Carcinogenesis |
Q37994933 | Activation-induced cytidine deaminase in antibody diversification and chromosome translocation |
Q40801731 | Affinity maturation of lymphocyte receptors and positive selection of T cells in the thymus |
Q33584295 | An immunoglobulin mutator that targets G.C base pairs |
Q33391280 | Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications |
Q34328629 | Analysis of somatic mutation in five B cell subsets of human tonsil |
Q45872648 | Autologous T lymphocytes recognize the tumour-derived immunoglobulin VH-CDR3 region in patients with B-cell chronic lymphocytic leukaemia |
Q38506144 | Chromatin domains and prediction of MAR sequences. |
Q37120876 | Clonal evolution of a follicular lymphoma: evidence for antigen selection |
Q37385073 | Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. |
Q42248453 | Comparison of somatic mutation frequency among immunoglobulin genes |
Q35851102 | Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines |
Q33622342 | Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer? |
Q36616139 | Effect of Helicobacter pylori eradication on ongoing mutation of immunoglobulin genes in gastric MALT lymphoma |
Q57307991 | Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes |
Q34063681 | Elucidation of IgH intronic enhancer functions via germ-line deletion |
Q40696086 | Generating the antibody repertoire in rabbit. |
Q34310757 | Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes |
Q33960151 | Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies |
Q34310763 | Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase |
Q36361415 | Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation |
Q28507519 | Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice |
Q38318053 | Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24. |
Q53665463 | Hypothesis: biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation. |
Q48037871 | Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase |
Q34114760 | Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line |
Q36362440 | In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells |
Q40802589 | In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains |
Q33237877 | Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies |
Q88293192 | JH6 downstream intronic sequence is dispensable for RNA polymerase II accumulation and somatic hypermutation of the variable gene in Ramos cells |
Q40983825 | Life and death in germinal centers (redux). |
Q37255156 | Ligation-anchored PCR: a simple amplification technique with single-sided specificity |
Q41359348 | Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse |
Q40505615 | Mechanisms of antigenic variation in Borrelia hermsii and African trypanosomes |
Q35939989 | Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation |
Q37587941 | Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response |
Q37525213 | Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes |
Q41083928 | Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication |
Q35953749 | On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes |
Q72875088 | Origin and maintenance of germ-line V genes |
Q45025354 | PCR amplification of murine immunoglobulin germline V genes: strategies for minimization of recombination artefacts |
Q46279727 | PIWIs, piRNAs and Retrotransposons: Complex battles during reprogramming in gametes and early embryos |
Q36172034 | Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots |
Q44870111 | Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection |
Q28087424 | RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome |
Q39720046 | Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice |
Q47996615 | Recombination signature of germline immunoglobulin variable genes |
Q64389096 | Recombination-based mechanisms for somatic hypermutation |
Q47108323 | Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory |
Q57295484 | Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation |
Q34468679 | Soma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC: The manifest polymorphism of the MHC appears greatly exceeded at Immunoglobulin loci, suggesting antigen-selected somatic V mutants penetrate Weismann's Barrie |
Q41222940 | Somatic diversification of antibody responses |
Q48103170 | Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions |
Q24652779 | Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes |
Q36399510 | Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase |
Q36361238 | Somatic hypermutation of an immunoglobulin mu heavy chain transgene |
Q70934062 | Somatic hypermutation of immunoglobulin genes is linked to transcription initiation |
Q41081725 | Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. |
Q34922043 | Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). |
Q33367730 | Somatic hypermutation: Another piece in the hypermutation puzzle |
Q55034838 | Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. |
Q37591443 | Somatic mutation in constant regions of mouse lambda 1 light chains |
Q40771425 | Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression |
Q40527478 | Targeting and regulation of immunoglobulin gene somatic hypermutation and isotype switch recombination |
Q54608320 | Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. |
Q48081907 | The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron |
Q50111104 | The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription. |
Q35734132 | The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes |
Q39645618 | The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially |
Q41049026 | The molecular basis of somatic hypermutation of immunoglobulin genes |
Q33770284 | The reverse transcriptase model of somatic hypermutation |
Q28592120 | The specificity and orientation of a TCR to its peptide-MHC class II ligands |
Q28190690 | Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand |
Q42799816 | Variable region gene selection of immunoglobulin G‐expressing B cells with specificity for a defined epitope on type II collagen |
Q35219287 | c-mycHypermutation in Burkitt's Lymphoma |