Estimating Hypermutation Rates from Clonal Tree Data

scientific article published on November 1, 2003

Estimating Hypermutation Rates from Clonal Tree Data is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.171.9.4639
P8608Fatcat IDrelease_7dgxkpq3dvea7o5zvl2gygxayi
P953full work available at URLhttp://www.jimmunol.org/content/171/9/4639.full.pdf
https://journals.aai.org/jimmunol/article-pdf/171/9/4639/1171110/4639.pdf
P698PubMed publication ID14568938
P5875ResearchGate publication ID231584270

P50authorMark ShlomchikQ29887913
P2093author name stringYoram Louzoun
Steven H. Kleinstein
P2860cites workCell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genesQ40840741
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell lineQ40982321
Intraclonal generation of antibody mutants in germinal centresQ41172275
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.Q41380981
Somatic mutation in ectothermic vertebrates: musings on selection and origins.Q41711161
Evolution of somatic hypermutation and gene conversion in adaptive immunityQ42678194
Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centersQ42944615
Toward quantitative simulation of germinal center dynamics: biological and modeling insights from experimental validationQ43667939
Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?Q52122457
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.Q52192552
Somatic hypermutation in B cells: an optimal control treatment.Q52390653
The role of clonal selection and somatic mutation in autoimmunityQ59082893
Affinity maturation and hypermutation in a simulation of the humoral immune responseQ71118314
Cutting edge: germinal centers can be induced in the absence of T cellsQ74064915
Evolution of autoantibody responses via somatic hypermutation outside of germinal centersQ74813307
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain diseaseQ24682616
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomasQ28217205
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritisQ33611035
Modeling and optimization of populations subject to time-dependent mutationQ33958359
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centersQ36231790
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutininQ36261566
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig lociQ36322298
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.Q36367466
Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centersQ36734151
Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell lineQ37675025
Measurements of mutation rates in B lymphocytes.Q39658912
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
immunological modelQ73510037
P304page(s)4639-4649
P577publication date2003-11-01
P1433published inJournal of ImmunologyQ3521441
P1476titleEstimating hypermutation rates from clonal tree data
Estimating Hypermutation Rates from Clonal Tree Data
P478volume171

Reverse relations

cites work (P2860)
Q55514140A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data.
Q40818553AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity
Q42206660Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites
Q55438933Cell Cycle-Associated CXCR4 Expression in Germinal Center B Cells and Its Implications on Affinity Maturation.
Q30970597Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data
Q35327599Characterizing immune repertoires by high throughput sequencing: strategies and applications.
Q35075665Detecting selection in immunoglobulin sequences
Q35127575Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation
Q39141825Estimate of within population incremental selection through branch imbalance in lineage trees.
Q43462113Exploration of factors affecting the onset and maturation course of follicular lymphoma through simulations of the germinal center
Q36274750Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data.
Q35070813In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis
Q64079637Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming
Q41934489Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences
Q31107783Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of "towards analysis" in chronic lymphocytic leukaemia
Q53040832Lambda light chain revision in the human intestinal IgA response.
Q36975946Lineage structure of the human antibody repertoire in response to influenza vaccination
Q30706182Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data
Q64102292Mutating for Good: DNA Damage Responses During Somatic Hypermutation
Q28607156Practical guidelines for B-cell receptor repertoire sequencing analysis
Q35628846Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification
Q34609455Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation
Q35695606Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.
Q42149724Somatic hypermutation targeting is influenced by location within the immunoglobulin V region
Q41831629T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells
Q38592595T-cell receptor profiling in cancer
Q36845667Targeting of AID-mediated sequence diversification by cis-acting determinants
Q57178227The Bayesian optimist's guide to adaptive immune receptor repertoire analysis
Q26801600The analysis of clonal expansions in normal and autoimmune B cell repertoires
Q36762508The evolution of mathematical immunology
Q42015134The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales
Q37346110The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis
Q33817545The whole-organism heavy chain B cell repertoire from Zebrafish self-organizes into distinct network features
Q55491385Transient AID expression for in situ mutagenesis with improved cellular fitness.
Q52688244Using Genotype Abundance to Improve Phylogenetic Inference.

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