AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

scientific article published on 21 June 2009

AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NSMB.1623
P932PMC publication ID4851237
P698PubMed publication ID19543289
P5875ResearchGate publication ID26307983

P2093author name stringMichael S Neuberger
Meng Wang
Cristina Rada
Zizhen Yang
P2860cites workAPOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposonsQ24307450
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1Q24336265
Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implicationsQ24646317
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationQ24646923
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminaseQ24653222
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateQ24802780
Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3GQ27649897
Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoterQ27860697
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationQ28208979
miR-181b negatively regulates activation-induced cytidine deaminase in B cellsQ28508305
Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localizationQ30483676
Estimating Hypermutation Rates from Clonal Tree DataQ30882543
Replication protein A interacts with AID to promote deamination of somatic hypermutation targetsQ31099047
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammalsQ33385376
Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivoQ33392701
The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversionsQ33567384
Modeling and optimization of populations subject to time-dependent mutationQ33958359
A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutionsQ34290231
Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.Q34578359
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.Q36146840
Dependence of antibody gene diversification on uracil excision.Q36294382
Inter- and intraclonal diversity in the antibody response to influenza hemagglutininQ36355399
Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reactionQ36465052
Protein evolution by hypermutation and selection in the B cell line DT40Q36471434
Activation-induced deaminase: light and dark sidesQ36544014
Molecular mechanisms of antibody somatic hypermutation.Q36747477
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor developmentQ36853393
Regulation of class switch recombination and somatic mutation by AID phosphorylationQ36946561
Guidelines for naming nonprimate APOBEC3 genes and proteinsQ37033420
Estrogen directly activates AID transcription and functionQ37061875
The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelementsQ37096085
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocationsQ37269390
Evolution of new nonantibody proteins via iterative somatic hypermutation.Q37627375
Mutation drift and repertoire shift in the maturation of the immune responseQ39658890
Isolation and characterization of an Escherichia coli strain with a high frequency of C-to-T mutations at 5-methylcytosinesQ39929800
Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding.Q40029354
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminaseQ40515192
C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Q40627624
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell linesQ40697370
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutationQ40782991
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.Q42101206
AID mutant analyses indicate requirement for class-switch-specific cofactorsQ42798287
APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot trafficQ42861821
Constitutive expression of AID leads to tumorigenesisQ42944928
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.Q45117058
Somatic hypermutation in B cells: an optimal control treatment.Q52390653
Affinity maturation and hypermutation in a simulation of the humoral immune responseQ71118314
Insights into DNA deaminasesQ79487889
P433issue7
P304page(s)769-776
P577publication date2009-06-21
P1433published inNature Structural & Molecular BiologyQ1071739
P1476titleAID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity
P478volume16

Reverse relations

cites work (P2860)
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Q30537745AID and Apobec3G haphazard deamination and mutational diversity
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Q26768663Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity
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