Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.

scientific article

Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.177402
P932PMC publication ID3003395
P698PubMed publication ID20929867

P50authorRobert F. SilicianoQ7344216
Robert W. MaulQ54437945
Rahul M. KohliQ55189769
Huseyin SaribasakQ55397173
P2093author name stringJames T Stivers
Patricia J Gearhart
Moira A McMahon
Kiran S Gajula
Amy F Guminski
Rhonda L McClure
P2860cites workActivation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)Q24290325
Codon and amino acid usage in retroviral genomes is consistent with virus-specific nucleotide pressureQ24498128
Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificitiesQ24521469
Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replicationQ24563503
Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activityQ24565021
APOBEC3G contributes to HIV-1 variation through sublethal mutagenesisQ24618320
Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implicationsQ24646317
Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1Q24655541
Cytidine deamination induced HIV-1 drug resistanceQ24657298
Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3GQ27649897
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinQ27860488
WebLogo: A Sequence Logo GeneratorQ27860646
DNA deamination mediates innate immunity to retroviral infectionQ28179534
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF ComplexQ28210666
APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivoQ28275837
The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domainQ28302167
RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1Q28474904
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genomeQ29618742
APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms.Q33826968
Determinants of sequence-specificity within human AID and APOBEC3GQ33885890
HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.Q33887160
Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressureQ34120736
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cellsQ34188845
Targeting of somatic hypermutationQ34551108
The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cellsQ35888172
Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variantQ35947586
Lethal mutagenesis of HIV.Q36008905
Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.Q36315163
The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restrictionQ36484144
Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formationQ36666251
Role of AID in tumorigenesisQ36845685
Conserved footprints of APOBEC3G on Hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequencesQ36845949
Dissecting APOBEC3G substrate specificity by nucleoside analog interference.Q37119821
APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNAQ37131958
Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.Q37273168
A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.Q37371679
DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombinationQ37397523
Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition.Q37452063
Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.Q38449098
Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.Q39756116
Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependentQ39869882
Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutationsQ40338305
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminaseQ40515192
A quantitative assay for HIV DNA integration in vivoQ40809319
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activityQ40818553
Mechanism of R-loop formation at immunoglobulin class switch sequencesQ41887873
Non-redundancy of cytidine deaminases in class switch recombinationQ44781044
Rapid evolution of primate antiviral enzyme APOBEC3G.Q44938087
AID is required for c-myc/IgH chromosome translocations in vivoQ45021537
Complementary function of the two catalytic domains of APOBEC3G.Q45274484
Codon bias targets mutation.Q59081204
Insights into DNA deaminasesQ79487889
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)40956-40964
P577publication date2010-10-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleLocal sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification
P478volume285

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cites work (P2860)
Q40142288A putative antiviral role of plant cytidine deaminases
Q21131084AID and APOBECs span the gap between innate and adaptive immunity
Q30537745AID and Apobec3G haphazard deamination and mutational diversity
Q41917830AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.
Q45324625APOBEC Enzymes as Targets for Virus and Cancer Therapy.
Q36759909APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription
Q37402303APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.
Q36963205APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure
Q38394187APOBECs and virus restriction
Q28592936ATAD5 deficiency decreases B cell division and Igh recombination
Q28713968An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals
Q36540495Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases
Q88960625Characterization of molecular attributes that influence LINE-1 restriction by all seven human APOBEC3 proteins
Q36301232Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain
Q36184715DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B.
Q36173864Does DNA repair occur during somatic hypermutation?
Q41233203Error-prone DNA polymerase and oxidative stress increase the incidences of A to G mutations in tumors
Q34357412Evidence for APOBEC3B mutagenesis in multiple human cancers
Q49917892Harnessing natural DNA modifying activities for editing of the genome and epigenome.
Q34115490High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.
Q41562658Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.
Q59351278Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues
Q52621974Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
Q36033318Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination
Q37689834Mechanisms of base substitution mutagenesis in cancer genomes
Q57173759Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands
Q90598776Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing
Q42725143Molecular targeting of mutagenic AID and APOBEC deaminases
Q37091342Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity
Q41738413RNA-binding residues in the N-terminus of APOBEC3G influence its DNA sequence specificity and retrovirus restriction efficiency
Q35068754Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities
Q34375128Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells
Q37629738Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
Q37518666Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties
Q26862780The APOBEC3 family of retroelement restriction factors
Q37281847The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.
Q37946460The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.
Q40808215The in vitro Biochemical Characterization of an HIV-1 Restriction Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA Binding and Deamination
Q37265843The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.
Q35587316Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes
Q36842394Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

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