| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0065-2776(08)01005-5 |
| P698 | PubMed publication ID | 19231595 |
| P2093 | author name string | Ali A Zarrin | |
| Yonglian Sun | |||
| Shahram Misaghi | |||
| Christopher Garris | |||
| Jason A Hackney | |||
| Kate Senger | |||
| Maria N Lorenzo | |||
| P2860 | cites work | The influence of transcriptional orientation on endogenous switch region function | Q73224719 |
| Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro | Q73794379 | ||
| Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination | Q74419737 | ||
| IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells | Q77995587 | ||
| Immunology. Antibodies get a break | Q79434409 | ||
| Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter | Q80884514 | ||
| Strand-biased spreading of mutations during somatic hypermutation | Q80970581 | ||
| Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) | Q24290325 | ||
| Internal IgH class switch region deletions are position-independent and enhanced by AID expression | Q24535261 | ||
| Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma | Q24561494 | ||
| IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates | Q24673255 | ||
| Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations | Q24678876 | ||
| Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase | Q24683335 | ||
| Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand | Q28190690 | ||
| Transcription-targeted DNA deamination by the AID antibody diversification enzyme | Q28190732 | ||
| Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas | Q28207345 | ||
| AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification | Q28208979 | ||
| IgH class switching and translocations use a robust non-classical end-joining pathway | Q28241679 | ||
| Evolution of isotype switching | Q28291304 | ||
| AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching | Q28366125 | ||
| Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation | Q28586304 | ||
| 53BP1 is required for class switch recombination | Q29465541 | ||
| 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. | Q29465548 | ||
| Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme | Q29547201 | ||
| Predominant autoantibody production by early human B cell precursors | Q29619656 | ||
| The immunoglobulin heavy chain locus of the duck. Genomic organization and expression of D, J, and C region genes | Q30732088 | ||
| Replication protein A interacts with AID to promote deamination of somatic hypermutation targets | Q31099047 | ||
| Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process | Q33198930 | ||
| Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase | Q33328760 | ||
| Influence of switch region length on immunoglobulin class switch recombination | Q33849665 | ||
| Genome-wide somatic hypermutation | Q33905110 | ||
| Elucidation of IgH intronic enhancer functions via germ-line deletion | Q34063681 | ||
| Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. | Q34147986 | ||
| Molecular aspects of somatic hypermutation of immunoglobulin genes | Q34170709 | ||
| R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells | Q34188845 | ||
| An intron-encoded protein is active in a gene conversion process that spreads an intron into a mitochondrial gene | Q34193487 | ||
| Immunoglobulins of the non-galliform birds: antibody expression and repertoire in the duck. | Q34449336 | ||
| Molecular mechanism of class switch recombination: linkage with somatic hypermutation | Q34542246 | ||
| AID and mismatch repair in antibody diversification | Q34770418 | ||
| Comparative analyses of immunoglobulin genes: surprises and portents | Q34810278 | ||
| DNA sequences at immunoglobulin switch region recombination sites | Q34963864 | ||
| Immunoglobulin genes: generating diversity with AID and UNG. | Q34990524 | ||
| Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions | Q34997657 | ||
| Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis | Q35033198 | ||
| Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus | Q35064395 | ||
| Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region | Q35950164 | ||
| Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences | Q36037736 | ||
| Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. | Q36146840 | ||
| Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice | Q36253581 | ||
| RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development | Q36303172 | ||
| Immunoglobulin gene diversification | Q36312189 | ||
| Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. | Q36315914 | ||
| The mu switch region tandem repeats are important, but not required, for antibody class switch recombination | Q36369023 | ||
| Somatic hypermutation shapes the antibody repertoire of memory B cells in humans | Q36369454 | ||
| H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation | Q36370913 | ||
| Defective B cell tolerance checkpoints in systemic lupus erythematosus | Q36402748 | ||
| Inducible DNA breaks in Ig S regions are dependent on AID and UNG | Q36402801 | ||
| AID from bony fish catalyzes class switch recombination | Q36403021 | ||
| Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor | Q36403873 | ||
| Somatic hypermutation: subverted DNA repair | Q36449996 | ||
| The plasticity of immunoglobulin gene systems in evolution | Q36453340 | ||
| Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching | Q36742253 | ||
| Molecular mechanisms of antibody somatic hypermutation. | Q36747477 | ||
| Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors | Q36775342 | ||
| Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals | Q36890934 | ||
| Regulation of autoreactive antibodies | Q36925329 | ||
| B-cell self-tolerance in humans | Q36942517 | ||
| Germinal centres: role in B-cell physiology and malignancy | Q37039584 | ||
| Antibody diversification by somatic mutation: from Burnet onwards | Q37052624 | ||
| S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase | Q37164427 | ||
| Antibody class switching mediated by yeast endonuclease-generated DNA breaks. | Q40196054 | ||
| Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination | Q40240123 | ||
| Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase | Q40515192 | ||
| Unique sequences are interspersed among tandemly repeated elements in the murine gamma 1 switch segment | Q40567685 | ||
| Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions | Q40982327 | ||
| Shutdown of class switch recombination by deletion of a switch region control element. | Q41573717 | ||
| Mechanism of R-loop formation at immunoglobulin class switch sequences | Q41887873 | ||
| AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner. | Q42101206 | ||
| The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice | Q42286497 | ||
| Evolution of somatic hypermutation and gene conversion in adaptive immunity | Q42678194 | ||
| AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts | Q42813803 | ||
| Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice | Q44194766 | ||
| Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation | Q44486460 | ||
| DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine | Q44674042 | ||
| Transcription-coupled events associating with immunoglobulin switch region chromatin | Q44699066 | ||
| Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat. | Q44764176 | ||
| Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination | Q44811129 | ||
| AID is required for c-myc/IgH chromosome translocations in vivo | Q45021537 | ||
| An evolutionarily conserved target motif for immunoglobulin class-switch recombination | Q45143151 | ||
| AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutation | Q46531711 | ||
| Two levels of protection for the B cell genome during somatic hypermutation. | Q46755254 | ||
| Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID. | Q46807599 | ||
| H2AX prevents DNA breaks from progressing to chromosome breaks and translocations | Q46904251 | ||
| Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair | Q46942139 | ||
| Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes | Q47982616 | ||
| Evidence for an early appearance of modern post-switch immunoglobulin isotypes in mammalian evolution (II); cloning of IgE, IgG1 and IgG2 from a monotreme, the duck-billed platypus, Ornithorhynchus anatinus | Q48284712 | ||
| An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching. | Q54113532 | ||
| Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. | Q54608320 | ||
| G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas. | Q55043612 | ||
| Genome analysis of the platypus reveals unique signatures of evolution | Q56929240 | ||
| A class switch control region at the 3′ end of the immunoglobulin heavy chain locus | Q59886033 | ||
| Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting | Q60016929 | ||
| Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region | Q60370477 | ||
| P921 | main subject | antibody | Q79460 |
| P304 | page(s) | 163-189 | |
| P577 | publication date | 2009-01-01 | |
| P1433 | published in | Advances in Immunology | Q15752932 |
| P1476 | title | DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination | |
| P478 | volume | 101 |
| Q34550504 | AID-initiated DNA lesions are differentially processed in distinct B cell populations |
| Q46253139 | B Cell Intrinsic Mechanisms Constraining IgE Memory. |
| Q38305602 | Biology of IgE production: IgE cell differentiation and the memory of IgE responses |
| Q36634895 | Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis. |
| Q90057553 | Current insights into the mechanism of mammalian immunoglobulin class switch recombination |
| Q48162385 | Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination. |
| Q33569786 | Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region. |
| Q36983081 | Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases |
| Q33690522 | Generation and repair of AID-initiated DNA lesions in B lymphocytes |
| Q34115490 | High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase. |
| Q36304948 | Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. |
| Q36534234 | Immunoglobulin class-switch DNA recombination: induction, targeting and beyond |
| Q36597287 | Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions |
| Q34412763 | Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification. |
| Q33531510 | Mechanisms of chromosomal rearrangement in the human genome |
| Q35105143 | Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination |
| Q37203980 | Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination |
| Q96135572 | REV7 is required for processing AID initiated DNA lesions in activated B cells |
| Q36855920 | RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts |
| Q27000758 | Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination |
| Q38388195 | Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes |
| Q37339890 | Shark IgW C region diversification through RNA processing and isotype switching |
| Q37055536 | The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells |
| Q37322165 | The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response |
| Q38195702 | The production and regulation of IgE by the immune system |
| Q36191111 | The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombination |
| Q38041514 | The role of activation-induced deaminase in antibody diversification and genomic instability |
| Q38975929 | The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites |
| Q48110072 | Transcription factor YY1 can control AID-mediated mutagenesis in mice |
| Q26862917 | Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity |
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