Harnessing natural DNA modifying activities for editing of the genome and epigenome.

scientific article published on 13 February 2018

Harnessing natural DNA modifying activities for editing of the genome and epigenome. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CBPA.2018.01.016
P8608Fatcat IDrelease_ok6vrslnmvb63c4yhxkkx3t5fu
P932PMC publication ID6076857
P698PubMed publication ID29452938

P50authorMonica Yun LiuQ87021092
Kiara N BerriosQ87809180
P2093author name stringJamie E DeNizio
Rahul M Kohli
Emily K Schutsky
P2860cites workDNA methylation on N(6)-adenine in mammalian embryonic stem cellsQ30796539
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N6-methyldeoxyadenosine marks active transcription start sites in ChlamydomonasQ34043896
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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavageQ34046684
A CRISPR-based approach for targeted DNA demethylationQ34047222
Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusionsQ34047321
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Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.Q37330630
CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter.Q37564798
A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosineQ37701368
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Editing DNA Methylation in the Mammalian GenomeQ38744151
Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable NucleasesQ38757646
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Quantitative LC-MS Provides No Evidence for m6 dA or m4 dC in the Genome of Mouse Embryonic Stem Cells and TissuesQ38858959
Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNAQ38921717
Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesQ38943944
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activityQ39230783
TET-mediated active DNA demethylation: mechanism, function and beyondQ39337480
Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.Q40104894
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activityQ40818553
APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.Q41510570
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.Q41562658
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A.Q41706069
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.Q41917830
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusionsQ41960134
Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferaseQ42291815
Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics.Q42322827
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognitionQ42376151
Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cellsQ46358101
Engineering DNA Backbone Interactions Results in TALE Scaffolds with Enhanced 5-Methylcytosine SelectivityQ47099490
Interrogating Key Positions of Size-Reduced TALE Repeats Reveals a Programmable Sensor of 5-CarboxylcytosineQ47250709
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavageQ47328087
CRISPR/Cas9-Based Engineering of the EpigenomeQ47594679
Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.Q48180112
Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusionQ50453614
Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain.Q51104418
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.Q51215555
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes.Q52427548
Programmable sensors of 5-hydroxymethylcytosine.Q53346687
P304page(s)10-17
P577publication date2018-02-13
P1433published inCurrent Opinion in Chemical BiologyQ15758415
P1476titleHarnessing natural DNA modifying activities for editing of the genome and epigenome
P478volume45

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cites work (P2860)
Q91658985A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation
Q89503064A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In Vivo
Q58615492Selectivity and Promiscuity in TET-mediated oxidation of 5-methylcytosine in DNA and RNA

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