Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

scientific article

Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NMETH.4027
P698PubMed publication ID27723754

P50authorXing ChangQ57035048
P2093author name stringYunqing Ma
Yan Song
Zhenchao Zhang
Jiayuan Zhang
Weijie Yin
P2860cites workIntricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturationQ36403602
Molecular mechanisms of antibody somatic hypermutation.Q36747477
The biochemistry of somatic hypermutationQ37096080
Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.Q38874534
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombinationQ40240123
C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Q40627624
Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loopsQ41098123
Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesisQ41835481
Analyzing CRISPR genome-editing experiments with CRISPRessoQ42551389
A system for the continuous directed evolution of biomoleculesQ42723725
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblastsQ42813803
Separate domains of AID are required for somatic hypermutation and class-switch recombinationQ42828095
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistanceQ43966244
Man-made cell-like compartments for molecular evolutionQ47857062
Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strandsQ48009144
Estimate of the mutation rate per nucleotide in humansQ24548130
Cas9 as a versatile tool for engineering biologyQ24564294
Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemiaQ24599829
Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial librariesQ24630061
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial ImmunityQ24669850
Structural basis for the autoinhibition of c-Abl tyrosine kinaseQ27640773
Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNAQ27729896
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomasQ28217205
Development and applications of CRISPR-Cas9 for genome engineeringQ28241526
Genome editing. The new frontier of genome engineering with CRISPR-Cas9Q28252298
CRISPR--a widespread system that provides acquired resistance against phages in bacteria and archaeaQ29614740
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expressionQ29615784
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elementsQ29615788
Genetic screens in human cells using the CRISPR-Cas9 systemQ29617411
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationQ29618788
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies.Q33985645
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavageQ34046684
Saturation editing of genomic regions by multiplex homology-directed repairQ34143368
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.Q34147986
Structural basis for CRISPR RNA-guided DNA recognition by CascadeQ34175461
Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias.Q34175760
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cellsQ34188845
Mechanisms and implications of imatinib resistance mutations in BCR-ABL.Q34283884
A Heritable Recombination system for synthetic Darwinian evolution in yeastQ34588001
Evolution of enzyme catalysts caged in biomimetic gel-shell beadsQ35229077
Strategies to overcome resistance to targeted protein kinase inhibitorsQ35968384
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter AssayQ36040300
P433issue12
P304page(s)1029-1035
P577publication date2016-10-10
P1433published inNature MethodsQ680640
P1476titleTargeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells
P478volume13

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