An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

scientific article published on 30 July 2018

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NBT.4199
P932PMC publication ID6181770
P698PubMed publication ID30059493

P50authorJ. Keith JoungQ28033740
Kendell ClementQ56548714
P2093author name stringJing Zeng
Daniel E Bauer
Yuxuan Wu
Luca Pinello
Jason M Gehrke
Oliver Cervantes
P2860cites workTherapeutic genome editing: prospects and challengesQ28087380
Genome editing. The new frontier of genome engineering with CRISPR-Cas9Q28252298
A DNA sequence recognition loop on APOBEC3A controls substrate specificityQ28538801
CRISPR-Cas systems for editing, regulating and targeting genomesQ29615781
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleasesQ33593394
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificityQ33630551
Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.Q33786397
In vivo genome editing using Staphylococcus aureus Cas9Q34043628
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavageQ34046684
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleasesQ34454104
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.Q34507554
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.Q36178493
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative DimerizationQ36921174
The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.Q37265843
Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemiaQ37281429
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.Q37629738
Beta-thalassemia.Q37680651
Genome-wide target specificities of CRISPR RNA-guided programmable deaminasesQ38842681
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activityQ40818553
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.Q41562658
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusionsQ41960134
Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitorQ42071921
Analyzing CRISPR genome-editing experiments with CRISPRessoQ42551389
Correction of β-thalassemia mutant by base editor in human embryosQ46124667
Rescue of high-specificity Cas9 variants using sgRNAs with matched 5' nucleotidesQ46148608
Enhanced proofreading governs CRISPR-Cas9 targeting accuracyQ46347859
Three new beta-globin gene promoter mutations identified through newborn screeningQ46736299
Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage.Q48230762
Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion.Q48357710
Highly efficient RNA-guided base editing in mouse embryos.Q50986337
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.Q51215555
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.Q52430644
A novel promoter mutation (HBB: c.-75G>T) was identified as a cause of β(+)-thalassemiaQ86678985
P433issue10
P921main subjectCas9Q16965677
P304page(s)977-982
P577publication date2018-07-30
P1433published inNature BiotechnologyQ1893837
P1476titleAn APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
P478volume36

Reverse relations

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