Protein evolution by hypermutation and selection in the B cell line DT40

scientific article

Protein evolution by hypermutation and selection in the B cell line DT40 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKM616
P932PMC publication ID2248763
P698PubMed publication ID18073192
P5875ResearchGate publication ID5775599

P2093author name stringHiroshi Arakawa
Jean-Marie Buerstedde
Michael A Rieger
Hiroaki Kudo
Joachim W Ellwart
Randolph B Caldwell
Vera Batrak
P2860cites workEfficiently folding and circularly permuted variants of the Sapphire mutant of GFPQ24802652
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateQ24802780
Mutant loxP vectors for selectable marker recycle and conditional knock-outsQ24805563
Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell lineQ25255775
Crystal structure of venus, a yellow fluorescent protein with improved maturation and reduced environmental sensitivityQ27639755
Crystal structure of the Aequorea victoria green fluorescent proteinQ27733214
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applicationsQ28213193
FACS-optimized mutants of the green fluorescent protein (GFP)Q29547322
Rapid generation of specific antibodies by enhanced homologous recombinationQ33216046
In vitro evolution of proteins.Q33255426
Harnessing phage and ribosome display for antibody optimisationQ33258346
Use of the green fluorescent protein and its mutants in quantitative fluorescence microscopyQ33907871
Light chain gene conversion continues at high rate in an ALV-induced cell line.Q33918728
Molecular biology and mutation of green fluorescent protein.Q36334539
Evolution of new nonantibody proteins via iterative somatic hypermutation.Q37627375
Inducible site-directed recombination in mouse embryonic stem cellsQ39715564
Directed molecular evolution by somatic hypermutationQ40498168
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell linesQ40697370
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversionQ40750743
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutationQ40782991
Increased ratio of targeted to random integration after transfection of chicken B cell lines.Q41661575
Computational design of a biologically active enzymeQ44952128
Understanding structure-function relationships in the Aequorea victoria green fluorescent protein.Q46039885
Improved green fluorescent protein by molecular evolution using DNA shufflingQ47961174
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell lineQ21014462
protein evolutionQ59870539
P304page(s)e1
P577publication date2007-12-11
P1433published inNucleic Acids ResearchQ135122
P1476titleProtein evolution by hypermutation and selection in the B cell line DT40
P478volume36

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cites work (P2860)
Q88605066A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching
Q33398520A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation
Q38742546A double-strand break can trigger immunoglobulin gene conversion
Q40818553AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity
Q37325284Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line
Q34216459Affinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells
Q42905810Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display
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Q37444790Protein and genome evolution in Mammalian cells for biotechnology applications
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Q35239847Usefulness of a Darwinian system in a biotechnological application: evolution of optical window fluorescent protein variants under selective pressure

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