AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

scientific article published on December 2008

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2008.09.062
P932PMC publication ID2713603
P698PubMed publication ID19070574
P5875ResearchGate publication ID23651480

P50authorBernardo Reina San-MartinQ58880775
Davide F. RobbianiQ73336910
P2093author name stringMichel C Nussenzweig
André Nussenzweig
Hua Tang Chen
Anne E Corcoran
Daniel J Bolland
Simone Difilippantonio
Elsa Callen
Yair Dorsett
Anne Bothmer
P2860cites workActivation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)Q24290325
Internal IgH class switch region deletions are position-independent and enhanced by AID expressionQ24535261
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationQ24646923
Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V GenesQ24652779
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain diseaseQ24682616
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseQ24683335
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformationQ28141630
A structural view of cre-loxp site-specific recombinationQ28187547
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strandQ28190690
Transcription-targeted DNA deamination by the AID antibody diversification enzymeQ28190732
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomasQ28207345
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationQ28208979
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomasQ28270474
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switchingQ28366125
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cellsQ28509339
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaQ29614324
Myc dynamically and preferentially relocates to a transcription factory occupied by IghQ33290425
Fusion of DNA region to murine immunoglobulin heavy chain locus corresponds to plasmacytoma-associated chromosome translocationQ33933345
Peptide nucleic acid (PNA) binding-mediated gene regulationQ33977872
Structure of the biologically relevant G-quadruplex in the c-MYC promoterQ33998447
Translocation joins c-myc and immunoglobulin gamma 1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene.Q34055298
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.Q34147986
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cellsQ34188845
Engineering chromosomal rearrangements in miceQ34389499
Mechanisms of chromosomal translocations in B cell lymphomasQ34405423
Homing endonuclease structure and functionQ34473961
Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocationsQ34560703
Mechanism and regulation of class switch recombinationQ34764888
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Q34922043
Neoplastic development in plasma cellsQ35170940
Mechanism and regulation of human non-homologous DNA end-joiningQ35542018
myc function and regulationQ35671084
Spatial genome organizationQ35761807
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.Q36146840
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangementsQ36229165
A role for AID in chromosome translocations between c-myc and the IgH variable region.Q36229681
Repair of genome destabilizing lesionsQ36269556
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors.Q36321157
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig lociQ36322298
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cellsQ36327408
AID mediates hypermutation by deaminating single stranded DNA.Q36370366
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutationQ36370913
ATM is required for efficient recombination between immunoglobulin switch regionsQ36399334
Making myc.Q36451343
Molecular mechanisms of antibody somatic hypermutation.Q36747477
Evolution of the immunoglobulin heavy chain class switch recombination mechanismQ36845675
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor developmentQ36853393
Antigen receptor diversification and chromosome translocationsQ36887122
The c-myc promoter: still MysterY and challengeQ37013896
The biochemistry of somatic hypermutationQ37096080
Transcriptionally active c- myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasiaQ37602009
Transcriptional activation of the translocated c-myc oncogene in burkitt lymphomaQ37603193
Control of c-myc regulation in normal and neoplastic cells.Q37713213
Translocations among antibody genes in human cancerQ40161799
Frequent chromosomal translocations induced by DNA double-strand breaksQ40872179
AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutationQ41771550
Chromatin interaction mechanism of transcriptional control invivoQ41875311
Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reactionQ41908763
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomasQ42824425
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutationQ42944652
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient miceQ44194766
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutationQ44486460
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombinationQ44575368
AID is required for c-myc/IgH chromosome translocations in vivoQ45021537
Two levels of protection for the B cell genome during somatic hypermutation.Q46755254
Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig GenesQ47982616
Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomasQ48398102
RNA fluorescence in situ hybridization tagging and recovery of associated proteins to analyze in vivo chromatin interactionsQ51053304
Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locusQ52167089
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic miceQ57338722
DNA structure equilibria in the human c-myc geneQ70169162
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomasQ70425288
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female miceQ70624275
Spatial proximity of translocation-prone gene loci in human lymphomasQ73531485
The E box motif CAGGTG enhances somatic hypermutation without enhancing transcriptionQ73836537
A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcriptionQ81038720
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1028-1038
P577publication date2008-12-01
P1433published inCellQ655814
P1476titleAID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
P478volume135

Reverse relations

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Q41485230YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis
Q39216030Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL
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