scholarly article | Q13442814 |
P50 | author | Bernardo Reina San-Martin | Q58880775 |
Davide F. Robbiani | Q73336910 | ||
P2093 | author name string | Michel C Nussenzweig | |
André Nussenzweig | |||
Hua Tang Chen | |||
Anne E Corcoran | |||
Daniel J Bolland | |||
Simone Difilippantonio | |||
Elsa Callen | |||
Yair Dorsett | |||
Anne Bothmer | |||
P2860 | cites work | Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) | Q24290325 |
Internal IgH class switch region deletions are position-independent and enhanced by AID expression | Q24535261 | ||
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation | Q24646923 | ||
Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes | Q24652779 | ||
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease | Q24682616 | ||
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase | Q24683335 | ||
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation | Q28141630 | ||
A structural view of cre-loxp site-specific recombination | Q28187547 | ||
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand | Q28190690 | ||
Transcription-targeted DNA deamination by the AID antibody diversification enzyme | Q28190732 | ||
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas | Q28207345 | ||
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification | Q28208979 | ||
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas | Q28270474 | ||
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching | Q28366125 | ||
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells | Q28509339 | ||
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme | Q29547201 | ||
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia | Q29614324 | ||
Myc dynamically and preferentially relocates to a transcription factory occupied by Igh | Q33290425 | ||
Fusion of DNA region to murine immunoglobulin heavy chain locus corresponds to plasmacytoma-associated chromosome translocation | Q33933345 | ||
Peptide nucleic acid (PNA) binding-mediated gene regulation | Q33977872 | ||
Structure of the biologically relevant G-quadruplex in the c-MYC promoter | Q33998447 | ||
Translocation joins c-myc and immunoglobulin gamma 1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene. | Q34055298 | ||
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. | Q34147986 | ||
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells | Q34188845 | ||
Engineering chromosomal rearrangements in mice | Q34389499 | ||
Mechanisms of chromosomal translocations in B cell lymphomas | Q34405423 | ||
Homing endonuclease structure and function | Q34473961 | ||
Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations | Q34560703 | ||
Mechanism and regulation of class switch recombination | Q34764888 | ||
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). | Q34922043 | ||
Neoplastic development in plasma cells | Q35170940 | ||
Mechanism and regulation of human non-homologous DNA end-joining | Q35542018 | ||
myc function and regulation | Q35671084 | ||
Spatial genome organization | Q35761807 | ||
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. | Q36146840 | ||
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements | Q36229165 | ||
A role for AID in chromosome translocations between c-myc and the IgH variable region. | Q36229681 | ||
Repair of genome destabilizing lesions | Q36269556 | ||
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. | Q36321157 | ||
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci | Q36322298 | ||
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells | Q36327408 | ||
AID mediates hypermutation by deaminating single stranded DNA. | Q36370366 | ||
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation | Q36370913 | ||
ATM is required for efficient recombination between immunoglobulin switch regions | Q36399334 | ||
Making myc. | Q36451343 | ||
Molecular mechanisms of antibody somatic hypermutation. | Q36747477 | ||
Evolution of the immunoglobulin heavy chain class switch recombination mechanism | Q36845675 | ||
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development | Q36853393 | ||
Antigen receptor diversification and chromosome translocations | Q36887122 | ||
The c-myc promoter: still MysterY and challenge | Q37013896 | ||
The biochemistry of somatic hypermutation | Q37096080 | ||
Transcriptionally active c- myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia | Q37602009 | ||
Transcriptional activation of the translocated c-myc oncogene in burkitt lymphoma | Q37603193 | ||
Control of c-myc regulation in normal and neoplastic cells. | Q37713213 | ||
Translocations among antibody genes in human cancer | Q40161799 | ||
Frequent chromosomal translocations induced by DNA double-strand breaks | Q40872179 | ||
AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation | Q41771550 | ||
Chromatin interaction mechanism of transcriptional control invivo | Q41875311 | ||
Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction | Q41908763 | ||
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas | Q42824425 | ||
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation | Q42944652 | ||
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice | Q44194766 | ||
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation | Q44486460 | ||
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination | Q44575368 | ||
AID is required for c-myc/IgH chromosome translocations in vivo | Q45021537 | ||
Two levels of protection for the B cell genome during somatic hypermutation. | Q46755254 | ||
Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes | Q47982616 | ||
Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas | Q48398102 | ||
RNA fluorescence in situ hybridization tagging and recovery of associated proteins to analyze in vivo chromatin interactions | Q51053304 | ||
Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus | Q52167089 | ||
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice | Q57338722 | ||
DNA structure equilibria in the human c-myc gene | Q70169162 | ||
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas | Q70425288 | ||
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice | Q70624275 | ||
Spatial proximity of translocation-prone gene loci in human lymphomas | Q73531485 | ||
The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription | Q73836537 | ||
A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription | Q81038720 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 1028-1038 | |
P577 | publication date | 2008-12-01 | |
P1433 | published in | Cell | Q655814 |
P1476 | title | AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations | |
P478 | volume | 135 |
Q36856274 | 53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma |
Q29465538 | 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks |
Q33794964 | 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination |
Q37075949 | A Critical Context-Dependent Role for E Boxes in the Targeting of Somatic Hypermutation |
Q39452866 | A Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae |
Q37739072 | A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket |
Q48158448 | A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets. |
Q54203616 | A causal mechanism for childhood acute lymphoblastic leukaemia. |
Q36944883 | A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells |
Q35213561 | A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center |
Q36300767 | A mouse model for HIV-1 entry |
Q38990489 | A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis |
Q41677163 | A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers. |
Q37597979 | A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction |
Q57804608 | A tumor promoting phorbol ester causes a large increase in APOBEC3A and a moderate increase in APOBEC3B expression in a normal human keratinocyte cell line without increasing genomic uracils |
Q41995688 | AID Biology: A pathological and clinical perspective |
Q21131084 | AID and APOBECs span the gap between innate and adaptive immunity |
Q41414224 | AID expression in peripheral blood of children living in a malaria holoendemic region is associated with changes in B cell subsets and Epstein-Barr virus |
Q33839428 | AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants |
Q34770449 | AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells |
Q33588393 | AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations |
Q28265992 | AID targeting: old mysteries and new challenges |
Q40818553 | AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity |
Q34328206 | AID-Targeting and Hypermutation of Non-Immunoglobulin Genes Does Not Correlate with Proximity to Immunoglobulin Genes in Germinal Center B Cells |
Q36159467 | AID-expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway |
Q34550504 | AID-initiated DNA lesions are differentially processed in distinct B cell populations |
Q36104522 | AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer |
Q82919724 | AIDS-related BL and CD4 count: a clue? |
Q34661364 | APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination |
Q53359826 | ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo |
Q41893268 | ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis |
Q54389595 | Aberrant expression and mutation-inducing activity of AID in human lung cancer |
Q41839580 | Acquisition of Genetic Aberrations by Activation-Induced Cytidine Deaminase (AID) during Inflammation-Associated Carcinogenesis |
Q38017761 | Activation induced deaminase: How much and where? |
Q37351651 | Activation of Aicda gene transcription by Pax5 in plasmacytoma cells |
Q37994933 | Activation-Induced Cytidine Deaminase in Antibody Diversification and Chromosome Translocation |
Q87113173 | Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors |
Q34168766 | Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia |
Q42630118 | Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells |
Q98725994 | Activation-induced cytidine deaminase overexpression in double-hit lymphoma: potential target for novel anticancer therapy |
Q34357060 | Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5 |
Q36179581 | Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase. |
Q28279743 | Aggressive lymphomas |
Q37731158 | Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells |
Q41777384 | Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia |
Q42582794 | Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation |
Q54216843 | An Unmutated IgM Response to the Vi Polysaccharide of Salmonella Typhi Contributes to Protective Immunity in a Murine Model of Typhoid |
Q99608150 | An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells |
Q44134734 | Analysis of activation-induced cytidine deaminase mRNA levels in patients with chronic lymphocytic leukemia with different cytogenetic status |
Q58455677 | Analysis of genomic breakpoints in p190 and p210 BCR–ABL indicate distinct mechanisms of formation |
Q36154339 | Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice |
Q52579670 | Antigen-mediated regulation in monoclonal gammopathies and myeloma |
Q38363569 | Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. |
Q28567188 | Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene |
Q42359862 | Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model |
Q34748194 | B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity |
Q36965870 | B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice |
Q35004965 | BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma |
Q36216511 | Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A. |
Q37459803 | Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G. |
Q34189497 | Burkitt Lymphoma: Pathogenesis and Immune Evasion |
Q50956444 | Burkitt's Lymphoma |
Q34030708 | Burkitt's lymphoma |
Q22242922 | Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability |
Q38208308 | Cancer: A Tale of Aberrant PRR Response |
Q34152519 | Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis |
Q38043045 | Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase |
Q42185336 | Clonal selection in the germinal centre by regulated proliferation and hypermutation |
Q59810113 | Clonally related diffuse large B-cell lymphoma and interdigitating dendritic cell sarcoma sharing translocation |
Q36316915 | Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications |
Q36439752 | Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity |
Q47549299 | Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection |
Q90057553 | Current insights into the mechanism of mammalian immunoglobulin class switch recombination |
Q48250994 | Cutting Edge: The Transcription Factor Sox2 Regulates AID Expression in Class-Switched B Cells. |
Q36113662 | DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID |
Q36282872 | DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes |
Q37307101 | DNA deaminases: AIDing hormones in immunity and cancer |
Q64077615 | DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells |
Q37304668 | Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair |
Q33757410 | Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes |
Q52861943 | Development of Mouse Model Systems of Germinal Center Lymphomas |
Q54518451 | Differential positioning and close spatial proximity of translocation-prone genes in nonmalignant B-cells from multiple myeloma patients. |
Q64078028 | Distinct Requirements of CHD4 during B Cell Development and Antibody Response |
Q37813897 | Double-hit B-cell lymphomas |
Q87854901 | Double-stranded DNA break polarity skews repair pathway choice during intrachromosomal and interchromosomal recombination |
Q38596344 | EBV Persistence--Introducing the Virus |
Q51735191 | EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts. |
Q38113932 | End-joining, translocations and cancer |
Q37977130 | Epidemiology: clues to the pathogenesis of Burkitt lymphoma |
Q38310252 | Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis |
Q34831630 | Epigenetic targeting of activation-induced cytidine deaminase. |
Q35144590 | Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. |
Q26772330 | Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response |
Q26824570 | Epstein-Barr virus-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms |
Q56930876 | Epstein-Barr virus-associated lymphomas |
Q24649590 | Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes |
Q38965235 | Estradiol induces gene proximity and MLL-MLLT3 fusion in an activation-induced cytidine deaminase-mediated pathway |
Q35166501 | Etiopathogenesis of Burkitt's lymphoma: a lesson from a BL-like in CD1 mouse immune to Plasmodium yoelii yoelii |
Q52837654 | Exploring the Role of Microbiota in the Limiting of B1 and MZ B-Cell Numbers by Naturally Secreted Immunoglobulins |
Q51580120 | FGFR3 preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B-cells when FGFR3 is located outside of CT4. |
Q34828445 | Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development. |
Q38170088 | Foxp3⁺ T(reg) cells in humoral immunity. |
Q38943944 | Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases |
Q55092495 | Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination. |
Q35143768 | Generation and characterization of induced pluripotent stem cells from Aid-deficient mice |
Q33690522 | Generation and repair of AID-initiated DNA lesions in B lymphocytes |
Q35026963 | Genetic reporter system for oncogenic Igh-Myc translocations in mice. |
Q38626707 | Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells |
Q39154178 | Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells. |
Q35280881 | Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development |
Q35145329 | Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression |
Q37776353 | Helicobacter pylori-induced activation-induced cytidine deaminase expression and carcinogenesis |
Q56913678 | High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis |
Q37865973 | How does DNA break during chromosomal translocations? |
Q37563700 | How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma? |
Q34974240 | Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death |
Q34096475 | Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness |
Q35165170 | Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin |
Q28255066 | Hypermutation in human cancer genomes: footprints and mechanisms |
Q36776345 | Identification of Early Replicating Fragile Sites that Contribute to Genome Instability |
Q45055253 | Identification of IGHCδ–BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B‐cell lymphoma/leukemia |
Q36249443 | Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas |
Q45934875 | Immunology: B cells break the rules. |
Q36818340 | Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory |
Q37323207 | Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A. |
Q91717494 | Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID |
Q35783785 | Long Noncoding RNA Expression during Human B-Cell Development |
Q33573534 | Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. |
Q38979865 | MGUS to myeloma: a mysterious gammopathy of underexplored significance |
Q37217649 | MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs. |
Q37894085 | Malignant B-cell intra-clonal diversification: following the yarn in the labyrinth |
Q36547669 | Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching |
Q28543483 | Mechanism of suppression of chromosomal instability by DNA polymerase POLQ |
Q38032210 | Mechanisms and impacts of chromosomal translocations in cancers |
Q33531510 | Mechanisms of chromosomal rearrangement in the human genome |
Q38843257 | Mechanisms of human lymphoid chromosomal translocations |
Q38188051 | Mechanisms of oncogenic chromosomal translocations |
Q34008189 | Mechanisms promoting translocations in editing and switching peripheral B cells |
Q38225013 | Mechanisms underlying mutational signatures in human cancers |
Q36079387 | Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation |
Q42325896 | Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy |
Q39119409 | Murine models of germinal center derived-lymphomas |
Q26768663 | Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity |
Q35742680 | Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells |
Q38123936 | New insights into pre-BCR and BCR signalling with relevance to B cell malignancies |
Q39206408 | Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription |
Q39766844 | Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer |
Q42179988 | Nucleolar tethering mediates pairing between the IgH and Myc loci |
Q36187330 | Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus |
Q24297481 | Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1 |
Q33870612 | Origin of chromosomal translocations in lymphoid cancer |
Q40843669 | PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCER |
Q28067519 | Parasite Infection, Carcinogenesis and Human Malignancy |
Q37273095 | Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination |
Q35637214 | Parp3 negatively regulates immunoglobulin class switch recombination. |
Q57050164 | Parp3 promotes long-range end joining in murine cells |
Q47419320 | Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene |
Q35961549 | Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma |
Q39096599 | Plasmodium chabaudi infection induces AID expression in transitional and marginal zone B cells |
Q26852071 | Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus |
Q84279386 | Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility |
Q37704005 | Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity |
Q64251926 | Primary Immunodeficiency and Cancer Predisposition Revisited: Embedding Two Closely Related Concepts Into an Integrative Conceptual Framework |
Q34271508 | R Loops: From Transcription Byproducts to Threats to Genome Stability |
Q42317970 | RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks |
Q45359347 | RBM5 promotes exon 4 skipping of AID pre‐mRNA by competing with the binding of U2AF65 to the polypyrimidine tract |
Q28087424 | RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome |
Q39015203 | RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing |
Q34537165 | RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle |
Q26853622 | Regulation of Aicda expression and AID activity |
Q36939328 | Regulation of B-cell development and function by microRNAs. |
Q35125130 | Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. |
Q36519034 | Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation |
Q34340626 | Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. |
Q34115234 | Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair |
Q33989467 | Repression of human activation induced cytidine deaminase by miR-93 and miR-155. |
Q37419452 | Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes |
Q29465549 | Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching |
Q37942329 | Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development |
Q38095676 | Role of microRNA in the pathogenesis of malignant lymphoma. |
Q33591714 | Role of the translocation partner in protection against AID-dependent chromosomal translocations |
Q35204691 | Separation of mutational and transcriptional enhancers in Ig genes |
Q38048886 | Sequence and structural basis for chromosomal fragility during translocations in cancer |
Q37240803 | Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1. |
Q28082525 | Snaps and mends: DNA breaks and chromosomal translocations |
Q24307502 | Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase |
Q35874015 | Spatial organization of the mouse genome and its role in recurrent chromosomal translocations |
Q35585086 | Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells |
Q36724272 | Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination. |
Q92003436 | Systematic Review of Somatic Mutations in Splenic Marginal Zone Lymphoma |
Q40182232 | Targeting Gene Function in Germinal Center B Cells: A Practical Approach |
Q39713047 | Targeting activation-induced cytidine deaminase overcomes tumor evasion of immunotherapy by CTLs |
Q91834942 | Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association |
Q34777596 | Targeting of AID-mediated sequence diversification to immunoglobulin genes |
Q84483321 | The 16th International Conference on Lymphatic Tissues and Germinal Centers in Immune Responses |
Q34099472 | The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia |
Q34247568 | The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells |
Q92963126 | The KT Jeang Prize 2019: Reuben S. Harris : Romancing the Mutator |
Q46299445 | The Proto-Oncogene c-mycRegulates Antibody Secretion and Ig Class Switch Recombination |
Q24337929 | The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates |
Q57091233 | The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes |
Q40561266 | The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. |
Q38018461 | The biochemistry of activation-induced deaminase and its physiological functions |
Q36944962 | The cellular etiology of chromosome translocations. |
Q52906715 | The dangers of transcription. |
Q34493999 | The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development |
Q48312712 | The microanatomic segregation of selection by apoptosis in the germinal center |
Q38041514 | The role of activation-induced deaminase in antibody diversification and genomic instability |
Q37781516 | The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers |
Q90343474 | The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities |
Q28512692 | The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA |
Q36328683 | ThehSSB1orthologueObfc2bis essential for skeletogenesis but dispensable for the DNA damage responsein vivo |
Q92087400 | Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation |
Q50141281 | Transcribing malignancy: transcription-associated genomic instability in cancer |
Q38236218 | Transcription and recombination: when RNA meets DNA. |
Q91844697 | Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting |
Q35773181 | Translocation capture sequencing: a method for high throughput mapping of chromosomal rearrangements |
Q35124628 | Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region |
Q35304991 | Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes |
Q37806625 | Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences |
Q36118300 | UNG shapes the specificity of AID-induced somatic hypermutation. |
Q61444171 | Up-regulation of activation-induced cytidine deaminase and its strong expression in extra-germinal centres in IgG4-related disease |
Q46004501 | V(D)J targeting mistakes occur at low frequency in acute lymphoblastic leukemia. |
Q37078589 | Visualizing antibody affinity maturation in germinal centers |
Q90859679 | Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage |
Q37677543 | Walking the AID tightrope |
Q34095055 | Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination |
Q38266298 | Wip1 phosphatase in breast cancer |
Q91644110 | Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies |
Q41485230 | YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis |
Q39216030 | Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL |
Q35238414 | cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. |
Q40340268 | miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma. |
Q86893123 | microRNA in Malignant Lymphoma |
Search more.