myc function and regulation

scientific article published on January 1, 1992

myc function and regulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1146/ANNUREV.BI.61.070192.004113
P698PubMed publication ID1497324
P5875ResearchGate publication ID21659045

P2093author name stringPatel AJ
Marcu KB
Bossone SA
P407language of work or nameEnglishQ1860
P1104number of pages52
P304page(s)809-860
P577publication date1992-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inAnnual Review of BiochemistryQ567356
P1476titlemyc function and regulation
P478volume61

Reverse relations

cites work (P2860)
Q4465967012-O-Tetradecanoylphorbol-13-acetate and UV Radiation-induced Nucleoside Diphosphate Protein Kinase B Mediates Neoplastic Transformation of Epidermal Cells
Q277657343'-Phosphorylated nucleotides are tight binding inhibitors of nucleoside diphosphate kinase activity
Q38297366A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors.
Q40023931A Role for c-myc in Chemically Induced Renal-Cell Death
Q38364182A computerized database-scan to identify c-MYC targets
Q24545231A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors
Q38572767A gastrin transcript expressed in gastrointestinal cancer cells contains an internal ribosome entry site
Q40445617A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma.
Q33957035A novel intron element operates posttranscriptionally To regulate human N-myc expression
Q24337051A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1
Q52708997A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system.
Q28564890A novel myc target gene, mina53, that is involved in cell proliferation
Q55481055A polymorphic variant of human c-Myc: Asn11-->Ser.
Q41100373A sequence in the 5′ flanking region confers progestin responsiveness on the human c-myc gene
Q38336574A single nucleotide change in the c-myc internal ribosome entry segment leads to enhanced binding of a group of protein factors
Q38307117A spectroscopic investigation of the interaction between c-MYC DNA and tetrapyridinoporphyrazinatozinc(II).
Q92865151A tunable assay for modulators of genome-destabilizing DNA structures
Q36559314A unique transactivation sequence motif is found in the carboxyl-terminal domain of the single-strand-binding protein FBP
Q37269390AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
Q40719036APC-dependent regulation of ornithine decarboxylase in human colon tumor cells
Q35094511Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis
Q36081076Abnormal pattern of post-gamma-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome
Q38338899Accelerated Proliferative Senescence of Rat Embryo Fibroblasts after Stable Transfection of Multiple Copies of the c-Myc DNA-Binding Sequence
Q39615527Acridine-modified, clamp-forming antisense oligonucleotides synergize with cisplatin to inhibit c-Myc expression and B16-F0 tumor progression
Q33840451Action of Myc in vivo - proliferation and apoptosis
Q39446781Activity of the c-myc replicator at an ectopic chromosomal location
Q47597394Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
Q36679535Addition of constitutive c-myc expression to Abelson murine leukemia virus changes the phenotype of the cells transformed by the virus from pre-B-cell lymphomas to plasmacytomas
Q33971890Alteration of the lipid profile in lymphomas induced by MYC overexpression
Q77140399Altered Differentiation of Hepatocytes in a Transgenic Mouse Model of Hepatocarcinogenesis
Q33635836Alternative DNA structure formation in the mutagenic human c-MYC promoter
Q38036415Alternative transcription and alternative splicing in cancer
Q77335768Amplification of c-myc gene and overexpression of c-Myc protein in breast cancer and adjacent non-neoplastic tissue
Q47918368Amplification of the translocated c-myc genes in three Burkitt lymphoma cell lines
Q37713114An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae
Q36550858An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants
Q34395958An In Silico Study of the Differential Effect of Oxidation on Two Biologically Relevant G-Quadruplexes: Possible Implications in Oncogene Expression
Q40523037An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1.
Q36549958An essential domain of the c-myc protein interacts with a nuclear factor that is also required for E1A-mediated transformation
Q24316326An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
Q38344632Analysis of E-box DNA binding during myeloid differentiation reveals complexes that contain Mad but not Max.
Q71259707Analysis of human breast cancer nuclear proteins binding to the promoter elements of the c-myc gene
Q39542252Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment
Q40916857Analysis of the murine AhR gene promoter
Q74688728Animal and cellular studies on carcinogenic effects of low frequency (50/60-Hz) magnetic fields
Q33556878Antiproliferative properties of the USF family of helix-loop-helix transcription factors
Q70480057Antisense of oligonucleotides and the inhibition of oncogene expression
Q40551607Apoptosis in viral infections
Q35855075Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus
Q42832476Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product
Q73097705B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation
Q73615245BLIMP-1: trigger for differentiation of myeloid lineage
Q36166789Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
Q34367152Bcr is a negative regulator of the Wnt signalling pathway
Q36671153Bile salts increase epithelial cell proliferation through HuR-induced c-Myc expression
Q48056857Binding of THZif-1, a MAZ-like zinc finger protein to the nuclease-hypersensitive element in the promoter region of the c-MYC protooncogene
Q41142636Biological aspects of multiple myeloma
Q38363473Biosensor detection of triplex formation by modified oligonucleotides
Q41011016Butyrate and the colonocyte. Implications for neoplasia
Q39811440Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation
Q41131125C-myc deregulation during transformation induction: involvement of 7SK RNA.
Q43956063C-myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells
Q77408505C-myc is not involved in cadmium-elicited apoptotic pathway in porcine kidney LLC-PK1 cells
Q36827796CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms
Q40864791Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis
Q41175989Cdc25 cell-cycle phosphatase as a target of c-myc
Q40787482Cdc25A phosphatase suppresses apoptosis induced by serum deprivation
Q36690298Cell cycle regulation of the c-Myc transcriptional activation domain
Q73445322Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity
Q64389573Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene
Q34449018Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor
Q42807945Characterization of the superinduction of the c-myc proto-oncogene in fibroblasts by benzamide derivatives
Q41338905Chromatin structure and function: the heretical path to an RNA transcription factor
Q34786043Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression
Q73595120Clinical implication of altered expression of Mad1 protein in human breast carcinoma
Q38300748Cloning and sequence of the feline max, and max 9 transcripts
Q35621945Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal
Q42802893Consensus-interferon and platelet-derived growth factor adversely regulate proliferation and migration of Kaposi's sarcoma cells by control of c-myc expression
Q28580840Constitutive heat shock protein 70 interacts with α-enolase and protects cardiomyocytes against oxidative stress
Q33985770Contrasting roles for Myc and Mad proteins in cellular growth and differentiation
Q38866151Cooverexpression of EpCAM and c-myc genes in malignant breast tumours.
Q36694963Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses
Q24805890Cryptic promoter activity in the DNA sequence corresponding to the pim-1 5'-UTR
Q41495304Cyclic AMP downregulates c-myc expression by inhibition of transcript initiation in human B-precursor Reh cells
Q36562487Cyclin D3 sensitizes tumor cells to tumor necrosis factor-induced, c-Myc-dependent apoptosis
Q33887377Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.
Q40568061Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway
Q32118758Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity
Q41600302DNA Conformation, Topology, and the Regulation of c-myc Expression
Q35208818DNA damage checkpoint control in cells exposed to ionizing radiation
Q37051064DNA secondary structures: stability and function of G-quadruplex structures
Q28262361DNA tetraplex formation in the control region of c-myc
Q34468606Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation.
Q40626921Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4.
Q28203672Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum
Q34637234Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program
Q41481874Defining a role for c-Myc in breast tumorigenesis.
Q52174737Definition of the human N-myc promoter region during development in a transgenic mouse model
Q28575519Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc
Q52199791Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization
Q41006195Developmentally regulated Xist promoter switch mediates initiation of X inactivation.
Q35957689Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells
Q72805213Different biological effects of the two protein kinase C activators bryostatin-1 and TPA on human carcinoma cell lines
Q41600312Differential Regulation of the c-MYC P1 and P2 Promoters in the Absence of Functional Tumor Suppressors: Implications for Mechanisms of Deregulated MYC Transcription
Q40902087Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta
Q73040900Differential expression of c-jun and c-myc in N-nitroso diethylamine-induced hepatic oncogenesis in AKR mice
Q38273722Differential regulation of MAP kinase cascade in human colorectal tumorigenesis
Q40241741Differential regulation of early response genes and cell proliferation through the human granulocyte macrophage colony-stimulating factor receptor: selective activation of the c-fos promoter by genistein
Q38347268Differential regulation of the N-myc proto-oncogene by ROR alpha and RVR, two orphan members of the superfamily of nuclear hormone receptors
Q33847130Differentiation and proliferation of pulmonary neuroendocrine cells
Q41379257Differentiation and transdifferentiation of the retinal pigment epithelium.
Q33536280Differentiation inhibitory factor Nm23 as a prognostic factor for acute myeloid leukemia
Q37719286Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene
Q24535577Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
Q34026482Disentangling the MYC web.
Q35078774Disrupting TP53 in mouse models of human cancers
Q42798685Distinct Roles for MAX Protein Isoforms in Proliferation and Apoptosis
Q36556463Do products of the myc proto-oncogene play a role in transcriptional regulation of the prothymosin alpha gene?
Q40881227ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1).
Q42983917Early response gene signalling in bryostatin-stimulated primary B chronic lymphocytic leukaemia cells in vitro
Q40863839Ectopic expression of Rsu-1 results in elevation of p21CIP and inhibits anchorage-independent growth of MCF7 breast cancer cells
Q38724038Effect of teicoplanin on the expression of c-myc and c-fos proto-oncogenes in MCF-7 breast cancer cell line
Q52177924Effects of EGF and TGFbeta1 on c-myc gene expression and DNA synthesis in embryonic hamster palate mesenchymal cells
Q40887267Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells
Q42475428Effects of polyamines, polyamine synthesis inhibitors, and polyamine analogs on casein kinase II using Myc oncoprotein as substrate
Q42088472Elevated polyamines induce c-MYC overexpression by perturbing quadruplex-WC duplex equilibrium
Q41063703Epstein-Barr virus nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin mu gene: implications for the expression of the translocated c-myc gene in Burkitt's lymphoma cells.
Q41099346Essential role of optimal protein synthesis in preventing the apoptotic death of cultured B cell hybridomas
Q39149804Establishment of an immortal chicken embryo liver-derived cell line
Q36562367Exon 2-mediated c-myc mRNA decay in vivo is independent of its translation
Q31152796Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis
Q41152233Exposure of embryonic cells to alcohol: contrasting effects during preimplantation and postimplantation development
Q31916381Expression cloning in Fe2+ transport defective yeast of a novel maize MYC transcription factor
Q61700558Expression of hpttg proto-oncogene in lymphoid neoplasias
Q60300456Expression of the human antimicrobial peptide β-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells
Q35071112FBPs are calibrated molecular tools to adjust gene expression
Q100416084FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells
Q36940362Four-stranded DNA: cancer, gene regulation and drug development
Q28198743Function and regulation of the transcription factors of the Myc/Max/Mad network
Q36567857Function of the c-Myc antagonist Mad1 during a molecular switch from proliferation to differentiation
Q34183768Function of the c-Myc oncoprotein in chromatin remodeling and transcription.
Q38360599Functional analysis of Burkitt's lymphoma mutant c-Myc proteins
Q34442961Functional analysis of the AUG- and CUG-initiated forms of the c-Myc protein
Q40913568Functional aspects of apoptosis in hematopoiesis and consequences of failure
Q22009062Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation
Q35885872Functions of myc:max in the control of cell proliferation and tumorigenesis
Q41264865Gastrin stimulates expression of protooncogene c-myc through a process involving polyamines in IEC-6 cells
Q36135022Genes related to growth and invasiveness are repressed by sodium butyrate in ovarian carcinoma cells.
Q40553433Genetic alterations in prostate adenocarcinoma.
Q34344691Genetic basis of pituitary adenoma invasiveness: a review
Q73978688Genetic changes in prostate cancer
Q43968784Genetic variants at chromosome 8q24, colorectal epithelial cell proliferation, and risk for incident, sporadic colorectal adenomas
Q33355172Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array
Q33350623Genome-wide screen identifies PVT1 as a regulator of Gemcitabine sensitivity in human pancreatic cancer cells
Q28278072Genomic Organization and Expression of a Human Gene for Myc-associated Zinc Finger Protein (MAZ)
Q41178239Genomic instability in MycER-activated Rat1A-MycER cells
Q44133878Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells
Q35915994Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc
Q40557274HER2 signaling enhances 5'UTR-mediated translation of c-Myc mRNA.
Q24310037HPV-18 E7 conjugates to c-Myc and mediates its transcriptional activity
Q40790676Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited
Q34811629Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner
Q24649693Heterogeneous nuclear ribonucleoprotein K is a transcription factor
Q37195219How the c-myc promoter works and why it sometimes does not.
Q36853031Human SWI/SNF drives sequence-directed repositioning of nucleosomes on C-myc promoter DNA minicircles
Q41204966Human T-cell leukemia virus type I tax masks c-Myc function through a cAMP-dependent pathway
Q34124162Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster
Q36959489Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics
Q41096536Hydrogen peroxide-induced expression of the proto-oncogenes, c-jun, c-fos and c-myc in rabbit lens epithelial cells
Q52845594Hypermethylation of PRDM1/Blimp-1 promoter in extranodal NK/T-cell lymphoma, nasal type: an evidence of predominant role in its downregulation
Q33640342I-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stability
Q42265040IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.
Q98779269Identification and Characterization of MAPK Signaling Pathway Genes and Associated lncRNAs in the Ileum of Piglets Infected by Clostridium perfringens Type C
Q24684304Identification of a large Myc-binding protein that contains RCC1-like repeats
Q40790463Identification of amino acid-base contacts in the Myc-DNA complex by site-specific bromouracil mediated photocrosslinking
Q24310637Identification of c- MYC as a Target of the APC Pathway
Q38760910Identification of pathway-based prognostic gene signatures in patients with multiple myeloma
Q34455807Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.
Q40392540Identification of two enhancer elements downstream of the human c-myc gene
Q78121372Implication of c-Myc in apoptosis induced by the retinoid CD437 in human lung carcinoma cells
Q90333802In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region of c-MYC Oncogene
Q39718464In vivo generation of 3' and 5' truncated species in the process of c-myc mRNA decay
Q71610816Inactivation of tumor suppressor genes and deregulation of the c-myc gene in urothelial cancer cell lines
Q36398127Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc
Q30979181Increasing alternative promoter repertories is positively associated with differential expression and disease susceptibility
Q54431566Inducement of G-quadruplex DNA forming and down-regulation of oncogene c-myc by bile acid-amino acid conjugate-BAA.
Q35043420Induction of apoptosis in cancer: new therapeutic opportunities
Q72275803Induction of apoptosis in oxygen-deprived cultures of hybridoma cells
Q71977685Influence of portein tyrosine phosphorylation on the experssion of the c‐myc oncogene in cancer of the large bowel
Q38339025Inhibition of Transcription of the Human c-myc Protooncogene by Intermolecular Triplex
Q41065536Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels
Q42672020Insulin-like Growth Factor I Induction of c-myc Expression in Bovine Fibroblasts Can Be Blocked by Antecedent Insulin Receptor Activation
Q31132980Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer
Q37152966Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk
Q31077729Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms
Q45754525Interactive Effects of c-myc and Transforming Growth Factor α Transgenes on Liver Tumor Development in Simian Virus 40 T Antigen Transgenic Mice
Q28355608Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stress
Q25257689Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death
Q38357468Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA-binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence
Q71679015Inverse expressions of the N-myc oncogene and beta 1 integrin in human neuroblastoma: relationships to disease progression in a nude mouse model system
Q40921623Is mucinous carcinoma of the colorectum a distinct genetic entity?
Q37256435It's T-ALL about Notch
Q36403645Janus‐faced role of SIRT1 in tumorigenesis
Q41520889K252a: a new blocker of the cell-cycle at G1 phase in a human hepatoma cell line
Q24816975Kinetic resolution of bimolecular hybridization versus intramolecular folding in nucleic acids by surface plasmon resonance: application to G-quadruplex/duplex competition in human c-myc promoter
Q41583865Kips off to Myc: Implications for TGFβ signaling
Q39757012Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues
Q47986931Ligand-induced conformational preorganization of loops of c-MYC G-quadruplex DNA and its implications in structure-specific drug design
Q30862704Light chain promoter regions in rainbow trout Oncorhynchus mykiss: function of a classical and an atypical Ig promoter.
Q71694545Long-range chromatin analysis of the human MYC locus by pulsed-field gel electrophoresis
Q40387253Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression
Q53417826Loss of USF transcriptional activity in breast cancer cell lines
Q34444076Loss of cell cycle controls in apoptotic lymphoblasts of the bursa of Fabricius.
Q24316955MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination
Q35848951MYC levels govern hematopoietic tumor type and latency in transgenic mice
Q38588878MYC: connecting selective transcriptional control to global RNA production.
Q38092448MYC‐y mice: From tumour initiation to therapeutic targeting of endogenous MYC
Q40981114Mad1 expression in the absence of differentiation: effect of cAMP on the B-lymphoid cell line Reh.
Q24310266Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
Q53850308Mapping and characterization of the minimal internal ribosome entry segment in the human c-myc mRNA 5' untranslated region
Q30450274Mechanism of c-myc regulation by c-Myb in different cell lineages
Q34119143Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery
Q28771749Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription
Q34230052Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo
Q34104558Modulation of Endothelial Cell Growth Arrest and Apoptosis by Vascular Endothelial Growth Inhibitor
Q28081657Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Q40829383Molecular and cytogenetic alterations in early stage of carcinogenesis of human lung
Q40922422Molecular biology of testicular germ cell tumors: current status
Q44587907Molecular characterisation and expression profiling of the ENO1 gene in the ovarian follicle of the Sichuan white goose
Q48058124Molecular cloning and characterization of a gene that encodes a MYC-related protein in Arabidopsis
Q42674787Molecular cloning, expression and chromosomal localization of mouse MM-1.
Q36287900Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting
Q46844799Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element
Q39719091Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene
Q73410749Mouse model for Burkitt's lymphoma will aid understanding and therapy
Q37603401Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism
Q34610790Multiple members of the E2F transcription factor family are the products of oncogenes
Q28776786Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo
Q52168084Multiprotein complexes present at the MIF motifs flanking the promoter of the human c-myc gene
Q37473327Mutational analysis of NM23-H2/NDP kinase identifies the structural domains critical to recognition of a c-myc regulatory element
Q37647273Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue
Q38329998Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF.
Q24563644Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner
Q33612685Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis
Q34062481Myc oncogenes: the enigmatic family
Q36711272Myc represses transcription of the growth arrest gene gas1
Q36568034Myc versus USF: discrimination at the cad gene is determined by core promoter elements
Q36678903Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2
Q33667285Myc-mediated transformation: the repression connection
Q38568550Myc: the beauty and the beast
Q34488830N-Myc and SP Regulate Phosphatidylserine Synthase-1 Expression in Brain and Glial Cells
Q92255940N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma
Q73394985N-myc over-expression downregulates alpha3beta1 integrin expression in human Saos-2 osteosarcoma cells
Q27655453NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1
Q28241326Negative control of the Myc protein by the stress-responsive kinase Pak2
Q40021079Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF.
Q80151845Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas
Q42456083Novel Transcriptional Mechanisms Are Involved in Regulating Preproenkephalin Gene Expressionin Vivo
Q40022897Nucleosomal Structures of c-myc Promoters with Transcriptionally Engaged RNA Polymerase II
Q41145808Nucleosomal structure of active and inactive c-myc genes
Q72427599Oncogene overexpression in non-small-cell lung cancer tissue: prevalence and clinicopathological significance
Q36208087Opposite regulation of gene transcription and cell proliferation by c-Myc and Max.
Q36664688Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis
Q74649765Over-expression and amplification of the c-myc gene in human urothelial carcinoma
Q24290150Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
Q41957982Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism
Q36009698Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice
Q37702161Overview of formation of G-quadruplex structures
Q33610890PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC.
Q41510725Pathways of p53-dependent apoptosis.
Q40625392Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization
Q28141456Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF
Q38820691Physiological Expression and Accumulation of the Products of Two Upstream Open Reading Frames mrtl and MycHex1 Along With p64 and p67 Myc From the Human c-myc Locus
Q55670934Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
Q34053472Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters.
Q42808134Polyamine depletion up-regulates c-Myc expression, yet induces G(1) arrest and terminal differentiation of F9 teratocarcinoma stem cells
Q38336940Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation
Q28570513Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation
Q39447889Polysaccharides from Capsosiphon fulvescens Stimulate the Growth of Gastrointestinal Cells
Q28575652Polysaccharides from Capsosiphon fulvescens Stimulate the Growth of IEC-6 Cells by Activating the MAPK Signaling Pathway
Q41600319Positive and Negative Regulation of c-Myc Transcription
Q37713271Prevention of diabetic alterations in transgenic mice overexpressing Myc in the liver.
Q55510639Prognostic significances of overexpression MYC and/or BCL2 in R-CHOP-treated diffuse large B-cell lymphoma: A Systematic review and meta-analysis.
Q73006569Proliferation, C-myc, and cyclin D1 expression in diffuse alveolar damage: potential roles in pathogenesis and implications for prognosis
Q36407796Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter
Q39230218Psoralen-modified clamp-forming antisense oligonucleotides reduce cellular c-Myc protein expression and B16-F0 proliferation
Q24629236Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1
Q41247962RRR-alpha-tocopheryl succinate induces apoptosis in avian retrovirus-transformed lymphoid cells
Q34654334Rapid identification of therapeutic targets in hematologic malignancies via functional genomics
Q52544957Recruitment of TRRAP required for oncogenic transformation by E1A.
Q37333643Reflecting on 25 years with MYC.
Q41600361Regulated Expression and Function of the c-Myc Antagonist, Mad1, During a Molecular Switch from Proliferation to Differentiation
Q40386886Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.
Q41542179Regulation of c-myc expression by sodium butyrate in the colon carcinoma cell line Caco-2.
Q40897143Regulation of c-myc transcription by interleukin-2 (IL-2). Identification of a novel IL-2 response element interacting with STAT-4.
Q34325611Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story
Q41374015Regulation of human ornithine decarboxylase expression following prolonged quiescence: role for the c-Myc/Max protein complex
Q45159479Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative
Q38316453Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters
Q37343986Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells
Q42712255Resveratrol inhibits proliferation, angiogenesis and induces apoptosis in colon cancer cells: calorie restriction is the force to the cytotoxicity
Q53475474Retrovirus-induced B cell neoplasia in the bursa of Fabricius.
Q33874286Reversible tumorigenesis by MYC in hematopoietic lineages
Q28201539Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation
Q34170995Role of B-lymphocyte-induced maturation protein-1 in terminal differentiation of B cells and other cell lineages
Q35853838Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts
Q34541307Role of transcription factors in the pathogenesis of pituitary adenomas: a review
Q24310015Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.
Q41859014SMARCAL1 Negatively Regulates C-Myc Transcription By Altering The Conformation Of The Promoter Region
Q37025168STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.
Q34970423Selection for c-myc integration sites in polyclonal T-cell lymphomas
Q36554700Selective and Rapid Nuclear Translocation of a c-Myc-Containing Complex after Fertilization of Xenopus laevis Eggs
Q41636913Short Chain Fatty Acid Regulation of Intestinal Gene Expression
Q43704421Short- and long-chain natural polyamines play specific roles in adult cricket neuroblast proliferation and neuron differentiation in vitro
Q41517451Signaling of programmed cell death induction in WEHI-231 B lymphoma cells
Q37409356Sin3 corepressor function in Myc-induced transcription and transformation
Q33508324Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation
Q36402664Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
Q27674707Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design
Q33193145Solution‐Phase Combinatorial Libraries: Modulating Cellular Signaling by Targeting Protein–Protein or Protein–DNA Interactions
Q42620818Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs
Q36305401Specific requirement of putrescine for the mitogenic action of juvenile hormone on adult insect neuroblasts
Q39168123Sphingosine kinase 1 overexpression stimulates intestinal epithelial cell proliferation through increased c-Myc translation
Q36293972Stabilization of HIF-1α and HIF-2α, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model
Q39918399Stable transfection of CHO cells with the c-myc gene results in increased proliferation rates, reduces serum dependency, and induces anchorage independence
Q22253226Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene
Q55475778Structural determinants for post-transcriptional stabilization of lactate dehydrogenase A mRNA by the protein kinase C signal pathway.
Q33915919Structural insights into G-quadruplexes: towards new anticancer drugs
Q40964746Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene
Q33998447Structure of the biologically relevant G-quadruplex in the c-MYC promoter
Q71472658Structure-activity relationship of 17 structural analogues of n-butyric acid upon c-myc expression
Q36978525Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions
Q30890618Studies characterizing 60 kda autoantibodies in subjects with schizophrenia
Q47741818Systemic short-chain fatty acids rapidly alter gastrointestinal structure, function, and expression of early response genes
Q56963006T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC
Q41244135TATA box and Sp1 sites mediate the activation of c-myc promoter P1 by immunoglobulin kappa enhancers.
Q33552252TFIIH operates through an expanded proximal promoter to fine-tune c-myc expression
Q40797081TGF-beta1 regulates the expression of multiple max-interacting transcription factors in Balb/MK cells: implications for understanding the mechanism of action of TGF-beta1.
Q71649711TGFβ1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures
Q33888207Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation.
Q28281008Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells
Q41351007Targeted melting and binding of a DNA regulatory element by a transactivator of c-myc
Q34174883Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Q34352558Targeting MYC Expression through G-Quadruplexes
Q33594302Telomerase activation. One step on the road to cancer?
Q34278442Tempol suppresses micronuclei formation in astrocytes of newborn rats exposed to 50-Hz, 10-mT electromagnetic fields under bleomycin administration
Q28140020The FBP interacting repressor targets TFIIH to inhibit activated transcription
Q24544008The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression
Q33791251The MYC dualism in growth and death
Q33967079The Max network gone mad.
Q36564631The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter
Q33667278The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation
Q38011958The Path from Skin to Brain: Generation of Functional Neurons from Fibroblasts
Q38748127The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance.
Q33667309The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation
Q40874517The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.
Q41600284The c-myc Story: Where we’ve been, Where we seem to be Going
Q37013896The c-myc promoter: still MysterY and challenge
Q38302512The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements
Q36875918The cloning and sequencing of an ovine c-myc cDNA.
Q27736408The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control
Q36646471The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition
Q33854150The frequencies of micronuclei induced by cisplatin in newborn rat astrocytes are increased by 50-Hz, 7.5- and 10-mT electromagnetic fields
Q40636620The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N- or c-myc
Q24322793The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization
Q36655671The human cut homeodomain protein represses transcription from the c-myc promoter
Q40041349The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen
Q36752403The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene
Q38323146The mouse Mel-18 "RING-finger" gene: genomic organization, promoter analysis and chromosomal assignment
Q36551303The myc intron-binding polypeptide associates with RFX1 in vivo and binds to the major histocompatibility complex class II promoter region, to the hepatitis B virus enhancer, and to regulatory regions of several distinct viral genes
Q37631442The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
Q39445586The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity
Q39716275The transactivation potential of a c-Myc N-terminal region (residues 92-143) is regulated by growth factor/Ras signaling
Q40519994The transcriptional regulation of the preproenkephalin gene
Q34242408Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intram
Q33864266Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma
Q41687948Transcription Factor-Based Drug Design in Anticancer Drug Development
Q36580981Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.
Q34173877Transcription factors and translocations in lymphoid and myeloid leukemia
Q35669591Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.
Q36088678Transcriptional regulation of mouse delta-opioid receptor gene
Q57382164Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc
Q39451978Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase
Q24313028Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins
Q44004521Transcriptomic rationale for the synergy observed with dasatinib + bortezomib + dexamethasone in multiple myeloma
Q40430362Transforming growth factor β and cancer
Q41212993Transforming growth factor-beta1 modulates p107 function in myeloid cells: correlation with cell cycle progression
Q36455522Transient excess of MYC activity can elicit genomic instability and tumorigenesis
Q53888869Translation of the human c-myc P0 tricistronic mRNA involves two independent internal ribosome entry sites.
Q33601644Translational control of growth factor and proto-oncogene expression
Q34405431Translocations involving c-myc and c-myc function
Q40821740Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the adenomatous polyposis coli (APC) tumor suppressor gene
Q34662891What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas
Q73420829Wild-type DNA sequence of the N-myc transactivation domain in human neuroblastoma
Q37288487YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels
Q36827465Yin-yang 1 activates the c-myc promoter
Q34157211You Don't Muck with MYC
Q78800431Zinc modulates c-Myc/Mad1 balance in human leukemia cells
Q77932393c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance
Q27671022c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability
Q53447394c-Myc Dependent Initiation of Genomic Instability During Neoplastic Transformation
Q45284395c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas
Q30718377c-Myc and Mxi1 immunoreactivities in the calcifying areas of the epiphyseal-plate cartilage matrix of growing rats
Q40228722c-Myc binds to 5' flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation
Q48062961c-Myc expression is controlled by the mitogenic cAMP-cascade in thyrocytes
Q33961819c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis.
Q33962550c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells
Q33956988c-Myc target genes involved in cell growth, apoptosis, and metabolism
Q36238451c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
Q41013204c-Myc-enhanced S phase entry in keratinocytes is associated with positive and negative effects on cyclin-dependent kinases
Q34771617c-Myc-induced extrachromosomal elements carry active chromatin
Q38346781c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene
Q33967371c-myc Internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice
Q40775797c-myc box II mutations in Burkitt's lymphoma-derived alleles reduce cell-transformation activity and lower response to broad apoptotic stimuli.
Q73174813c-myc in bladder cancer. Clinical findings and analysis of mechanism
Q38326977c-myc intron element-binding proteins are required for 1, 25-dihydroxyvitamin D3 regulation of c-myc during HL-60 cell differentiation and the involvement of HOXB4.
Q35212190c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets
Q24315822mrtl-A translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network
Q41299249p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines
Q35709920p53-Dependent induction of PVT1 and miR-1204.
Q38288618v-Abl activates c-myc transcription through the E2F site

Search more.