Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intram

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Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intram is …
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scholarly articleQ13442814

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P356DOI10.1021/BI100946G
P932PMC publication ID2964402
P698PubMed publication ID20849082
P5875ResearchGate publication ID46303327

P2093author name stringDanzhou Yang
Emmanuel Hatzakis
Keika Okamoto
P2860cites workDirect evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionQ24535577
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Biophysical and biological properties of quadruplex oligodeoxyribonucleotidesQ34966734
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Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cellsQ36327307
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Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoterQ36407796
Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer elementQ36557320
Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor geneQ36824041
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solutionQ36914814
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regionsQ36978525
Control of c-myc regulation in normal and neoplastic cells.Q37713213
The pathogenesis of Burkitt's lymphomaQ37888967
Quadruplex meltingQ38296936
Ion selective folding of loop domains in a potent anti-HIV oligonucleotideQ38342090
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Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivativesQ40161879
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Differential regulation of the c-MYC P1 and P2 promoters in the absence of functional tumor suppressors: implications for mechanisms of deregulated MYC transcription.Q41600312
Quadruplexes of human telomere dG(3)(TTAG(3))(3) sequences containing guanine abasic sitesQ42965774
Steroid hormone receptor immunohistochemistry and amplification of c-myc protooncogene. Relationship to disease-free survival in breast cancerQ45106864
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilizationQ45255075
Association of amplified oncogene c-myc with an abnormally banded chromosome 8 in a human leukaemia cell line.Q54486682
Oligonucleotide interactions. III. Circular dichroism studies of the conformation of deoxyoligonucleolidesQ71518126
PuF/NM23-H2/NDPK-B transactivates a human c-myc promoter-CAT gene via a functional nuclease hypersensitive elementQ72320125
Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinomaQ73154707
Sequence effects of single base loops in intramolecular quadruplex DNAQ80072701
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4Q80334969
Exceptionally slow kinetics of the intramolecular quadruplex formed by the Oxytricha telomeric repeatQ81436334
Stable lariat formation based on a G-quadruplex scaffoldQ84125106
P433issue43
P407language of work or nameEnglishQ1860
P304page(s)9152-9160
P577publication date2010-11-01
P1433published inBiochemistryQ764876
P1476titleThermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intram
P478volume49

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cites work (P2860)
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Q55250759Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex.
Q40135508Cyclic dinucleotide detection with riboswitch-G-quadruplex hybrid
Q90240156DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation
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Q54334207Keeping those telomeres short! an innovative intratumoral long-term drug delivery system.
Q35956052Kinetics and mechanism of G-quadruplex formation and conformational switch in a G-quadruplex of PS2.M induced by Pb²⁺
Q57366670Mapping the energy landscapes of supramolecular assembly by thermal hysteresis
Q57752886Pif1 helicase unfolding of G-quadruplex DNA is highly dependent on sequence and reaction conditions
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