Small molecule regulated dynamic structural changes of human G-quadruplexes

scientific article published on 12 February 2016

Small molecule regulated dynamic structural changes of human G-quadruplexes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/C6SC00057F
P932PMC publication ID6006475
P698PubMed publication ID29997820

P50authorHarald SchwalbeQ15453283
Shirsendu GhoshQ50232928
Irene BessiQ83837281
P2093author name stringKankan Bhattacharyya
Jyotirmayee Dash
Manish Debnath
Deepanjan Panda
P2860cites workQuadruplex DNA: sequence, topology and structureQ22065978
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionQ24535577
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solutionQ27648514
Structure of the Human Telomere in K + Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad LayersQ27654041
Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structuresQ27658371
Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug DesignQ27674707
Fluorescence spectroscopy of single biomolecules.Q31221311
Extreme conformational diversity in human telomeric DNAQ33229923
Fluorescence-based melting assays for studying quadruplex ligandsQ33283370
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligandsQ34028382
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Q34174883
Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intramQ34242408
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transferQ34382392
Telomere maintenance as a target for anticancer drug discoveryQ34743340
Developing DNA nanotechnology using single-molecule fluorescenceQ35168666
G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistryQ35645391
Kinetics of conformational fluctuations in DNA hairpin-loopsQ36206384
Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.Q36376130
Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Förster distance dependence and subpopulationsQ36448640
Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC.Q36717884
Single molecule conformational analysis of DNA G-quadruplexesQ37092887
G-quadruplex DNA bound by a synthetic ligand is highly dynamicQ37331983
Direct observation of ultrafast folding and denatured state dynamics in single protein moleculesQ37413448
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeuticsQ37631442
Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancerQ37642075
Folding and unfolding pathways of the human telomeric G-quadruplexQ37672413
Methods for investigating G-quadruplex DNA/ligand interactions.Q37896491
The application of DNA and RNA G-quadruplexes to therapeutic medicines.Q37905612
Conformational changes of non-B DNA.Q37928936
Investigating a quadruplex-ligand interaction by unfolding kineticsQ38311198
A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer CellsQ38842716
Putative DNA quadruplex formation within the human c-kit oncogeneQ41774419
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogeneQ42108961
Two-dimensional fluorescence lifetime correlation spectroscopy. 2. ApplicationQ42615492
Monitoring the conformational fluctuations of DNA hairpins using single-pair fluorescence resonance energy transferQ42654666
Fluorescence correlation spectroscopy. II. An experimental realizationQ43853123
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilizationQ45255075
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structureQ45289353
Single-molecule methods leap ahead.Q50448816
Interaction of G-quadruplex with RecA protein studied in bulk phase and at the single-molecule level.Q51004469
Fluorescence correlation spectroscopy. I. Conceptual basis and theoryQ56656039
FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin LoopQ57909274
Reversible Reconfiguration of DNA Origami Nanochambers Monitored by Single-Molecule FRETQ60081209
G-quadruplex DNA: a target for drug designQ77658670
pH-induced intramolecular folding dynamics of i-motif DNAQ84868119
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)3279-3285
P577publication date2016-02-12
P1433published inChemical ScienceQ2962267
P1476titleSmall molecule regulated dynamic structural changes of human G-quadruplexes
P478volume7

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cites work (P2860)
Q39229791A direct view of the complex multi-pathway folding of telomeric G-quadruplexes.
Q40194972An Aggregating Amphiphilic Squaraine: A Light-up Probe That Discriminates Parallel G-Quadruplexes
Q107159071Binding and Beyond: What Else Can G-Quadruplex Ligands Do?
Q47986931Ligand-induced conformational preorganization of loops of c-MYC G-quadruplex DNA and its implications in structure-specific drug design
Q90333042Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G-Quadruplex-Stabilizing Ligands with Improved Anticancer Activity
Q44694912Preferential targeting of i-motifs and G-quadruplexes by small molecules
Q39018694Single-molecule fluorescence resonance energy transfer in molecular biology

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