Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia

scientific article published on 15 April 2014

Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.201343853
P932PMC publication ID4209801
P698PubMed publication ID24668151
P5875ResearchGate publication ID260912364

P50authorNadja ZaborskyQ64213596
Roland GeisbergerQ42399953
Thomas K FelderQ57631136
Franz Josef GassnerQ64213594
P2093author name stringRichard Greil
Michael Huemer
Kemal Catakovic
Stefan Rebhandl
P2860cites workSolubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminaseQ24307502
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Q24307678
Molecules and their functions in autophagyQ24622004
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminaseQ24653222
Correlation between protein and mRNA abundance in yeastQ28137554
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutationQ28202500
Activation-induced cytidine deaminase splice variants are defective because of the lack of structural support for the catalytic site.Q30385115
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceQ30857687
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivoQ33392701
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expressionQ34068006
Lysine residue at position 22 of the AID protein regulates its class switch activity.Q34170147
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.Q34340626
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylationQ34695460
The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.Q34774397
Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathwaysQ35227491
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytesQ35304991
Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomicsQ35571380
REG-γ associates with and modulates the abundance of nuclear activation-induced deaminaseQ35669089
The regulation of somatic hypermutationQ35692214
Regulation of AID expression in the immune responseQ36229307
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functionsQ36462397
Immunoglobulin class-switch DNA recombination: induction, targeting and beyondQ36534234
Proteasomal degradation restricts the nuclear lifespan of AIDQ36699771
Molecular mechanisms of antibody somatic hypermutation.Q36747477
Regulation of class switch recombination and somatic mutation by AID phosphorylationQ36946561
Rate-limiting steps in yeast protein translationQ36959359
Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cellsQ37001985
The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequenceQ37167699
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocationsQ37269390
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cellsQ38626707
Activation of human B cells by phosphorothioate oligodeoxynucleotidesQ39770135
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signalingQ40150411
Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocationQ42582794
MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformationQ42820324
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation processQ42944711
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL diseaseQ43127229
Activation-induced cytidine deaminase splicing patterns in chronic lymphocytic leukemiaQ43179782
High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemiaQ44315242
Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone.Q44509645
AID splice variants lack deaminase activity.Q46116559
Two levels of protection for the B cell genome during somatic hypermutation.Q46755254
AID is required for germinal center-derived lymphomagenesisQ46861217
Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.Q53251673
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
stoichiometryQ213185
lymphocyteQ715347
chronic lymphocytic leukemiaQ1088156
P304page(s)2175-2187
P577publication date2014-04-15
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleAlternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia
P478volume44

Reverse relations

cites work (P2860)
Q34770449AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells
Q28085553AID/APOBEC deaminases and cancer
Q37593573Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation
Q35585086Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells

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