The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

scholarly article

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..106.6736G
P356DOI10.1073/PNAS.0810808106
P932PMC publication ID2672500
P698PubMed publication ID19351893
P5875ResearchGate publication ID24262835

P2093author name stringMichael S Neuberger
Cristina Rada
Roland Geisberger
P2860cites workImportins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domainsQ24292247
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Q24307678
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1Q24336265
AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localizationQ24531345
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationQ24646923
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminaseQ24653222
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateQ24802780
miR-181b negatively regulates activation-induced cytidine deaminase in B cellsQ28508305
Identification of a signal for rapid export of proteins from the nucleusQ29547742
Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358.Q33206242
Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomicsQ35571380
Importin beta: conducting a much larger cellular symphonyQ35938681
Dependence of antibody gene diversification on uracil excision.Q36294382
Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminaseQ36399510
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligaseQ36456463
Proteasomal degradation restricts the nuclear lifespan of AIDQ36699771
Molecular mechanisms of antibody somatic hypermutation.Q36747477
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor developmentQ36853393
Evidence for specific nucleocytoplasmic transport pathways used by leucine-rich nuclear export signalsQ37202345
Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaksQ40566152
C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Q40627624
Qualitative highly divergent nuclear export signals can regulate export by the competition for transport cofactors in vivoQ40788028
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- miceQ42286497
AID mutant analyses indicate requirement for class-switch-specific cofactorsQ42798287
Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritisQ46485635
Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2.Q46490209
Importin-mediated nuclear translocation of galectin-3.Q50710813
A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signalsQ73598439
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)6736-6741
P577publication date2009-04-07
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence
P478volume106

Reverse relations

cites work (P2860)
Q3966467414-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.
Q33605445A coming-of-age story: activation-induced cytidine deaminase turns 10.
Q41870415AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].
Q43112724AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.
Q28085553AID/APOBEC deaminases and cancer
Q37683558AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.
Q36592764Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.
Q34427913Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins
Q37994933Activation-induced cytidine deaminase in antibody diversification and chromosome translocation
Q64097227Activation-induced deaminase (AID) localizes to the nucleus in brief pulses
Q39756116Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.
Q41777384Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia
Q26799165Antibody Affinity Maturation in Fishes-Our Current Understanding
Q35930290Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.
Q37587676C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
Q24295504CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
Q35768862Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.
Q34152519Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis
Q36316915Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications
Q34958445Complex regulation and function of activation-induced cytidine deaminase
Q46566272Conflict of interests: multiple signal peptides with diverging goals
Q35289306Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.
Q90057553Current insights into the mechanism of mammalian immunoglobulin class switch recombination
Q35546818Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).
Q37304668Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair
Q52716066Diversity of Immunoglobulin (Ig) Isotypes and the Role of Activation-Induced Cytidine Deaminase (AID) in Fish.
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Q27300740Etoposide induces nuclear re-localisation of AID
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Q34438294Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair
Q35744148Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination
Q37323207Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A.
Q34170147Lysine residue at position 22 of the AID protein regulates its class switch activity.
Q42837072Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching
Q33829729Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans
Q28540726Processive DNA demethylation via DNA deaminase-induced lesion resolution
Q35669089REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase
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Q41771273The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin
Q28750273The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination
Q41981500The mechanisms regulating the subcellular localization of AID.

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