Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).

scientific article published on 31 October 2011

Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A). is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PNAS..10818366H
P356DOI10.1073/PNAS.1106729108
P932PMC publication ID3215039
P698PubMed publication ID22042842
P5875ResearchGate publication ID51760173

P2093author name stringMichael S Neuberger
Cristina Rada
Julien Häsler
P2860cites workHistone chaperone Spt6 is required for class switch recombination but not somatic hypermutationQ24300395
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Q24307678
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1Q24336265
AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localizationQ24531345
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseQ24683335
Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1BalphaQ27628860
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulumQ28275854
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceQ30857687
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutationQ33301257
Two forms of activation-induced cytidine deaminase differing in their ability to bind agaroseQ33527420
Light chain gene conversion continues at high rate in an ALV-induced cell line.Q33918728
eEF1A: thinking outside the ribosomeQ33967234
AID and somatic hypermutation.Q34118000
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cellsQ34249818
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.Q34340626
Moonlighting functions of polypeptide elongation factor 1: from actin bundling to zinc finger protein R1-associated nuclear localizationQ34544170
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylationQ34695460
Complex regulation and function of activation-induced cytidine deaminaseQ34958445
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.Q35144590
Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminaseQ36399510
Regulation of class switch recombination and somatic mutation by AID phosphorylationQ36946561
The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequenceQ37167699
Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaksQ40566152
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversionQ40750743
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activityQ40818553
Active nuclear import and cytoplasmic retention of activation-induced deaminaseQ41792388
Translation elongation factor 1A is essential for regulation of the actin cytoskeleton and cell morphologyQ46664399
pH regulation of the F-actin binding properties of Dictyostelium elongation factor 1 alphaQ72350413
P433issue45
P407language of work or nameEnglishQ1860
P921main subjectstoichiometryQ213185
P304page(s)18366-18371
P577publication date2011-10-31
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).
P478volume108

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cites work (P2860)
Q37739072A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket
Q41995688AID Biology: A pathological and clinical perspective
Q41684084Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
Q36592764Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.
Q40090064Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites
Q38001656An evolutionary view of the mechanism for immune and genome diversity
Q35289306Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.
Q38896854Cyclin-dependent kinases regulate Ig class switching by controlling access of AID to the switch region
Q55208667Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.
Q27300740Etoposide induces nuclear re-localisation of AID
Q38019962Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability
Q36906733GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy
Q36534234Immunoglobulin class-switch DNA recombination: induction, targeting and beyond
Q34469970LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase
Q42837072Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching
Q26768663Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity
Q37022423PARP activation promotes nuclear AID accumulation in lymphoma cells
Q43112311Pharmacological manipulation of AID.
Q26853622Regulation of Aicda expression and AID activity
Q24307502Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase
Q38778847Structural and functional assessment of APOBEC3G macromolecular complexes.
Q36890388The unexpected roles of eukaryotic translation elongation factors in RNA virus replication and pathogenesis
Q26862917Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity
Q39404034YY1 controls immunoglobulin class switch recombination and nuclear activation-induced deaminase levels

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