AID Biology: A pathological and clinical perspective

scientific article published on 21 September 2017

AID Biology: A pathological and clinical perspective is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/08830185.2017.1369980
P698PubMed publication ID28933967

P2093author name stringPrashant Kodgire
Monika Jain
Amit Kumar Singh
Ankit Jaiswal
Anubhav Tamrakar
Meenal Choudhary
P2860cites workActivation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombinationQ37659903
A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic PocketQ37739072
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)Q24290325
The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA SubstratesQ24337929
Somatic hypermutation of the AID transgene in B and non-B cellsQ24535846
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencingQ24612248
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationQ24633098
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseQ24683335
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateQ24802780
Tissue-specific spatial organization of genomesQ24805135
Immunity through DNA deaminationQ28182160
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strandQ28190690
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genesQ28190856
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomasQ28207345
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression programQ28216493
REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA MetabolismQ28245231
Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instabilityQ28253489
Class-switch recombination: interplay of transcription, DNA deamination and DNA repairQ28269740
Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogrammingQ28284694
Recombination centres and the orchestration of V(D)J recombinationQ28307066
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cellsQ28509339
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNAQ28512692
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemiaQ29547900
Inflammation meets cancer, with NF-κB as the matchmakerQ29620242
Replication protein A interacts with AID to promote deamination of somatic hypermutation targetsQ31099047
Rapid generation of specific antibodies by enhanced homologous recombinationQ33216046
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
Chromatin structure regulates gene conversionQ33299578
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Q33299999
A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutationQ33398520
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancersQ37781516
Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancersQ37793964
Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine DeaminaseQ38043045
Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cellsQ38302008
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cellsQ38626707
Gene conversion and the generation of antibody diversityQ38686688
Nucleosome Stability Dramatically Impacts the Targeting of Somatic HypermutationQ39384701
14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.Q39664674
The recruitment of activation induced cytidine deaminase to the immunoglobulin locus by a regulatory elementQ39723465
DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motifQ39895269
Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40.Q40009105
Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locusQ40016485
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signalingQ40150411
Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.Q40215373
E2A expression stimulates Ig hypermutationQ40265481
Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell linesQ40291765
Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutationsQ40338305
Somatic hypermutationQ40404787
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminaseQ40515192
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.Q40587079
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.Q40591358
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversionQ40750743
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutationQ40782991
Catalytic pocket inaccessibility of activation-induced cytidine deaminase is a safeguard against excessive mutagenic activityQ41328951
Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.Q41667047
Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reactionQ41908763
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.Q41917830
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.Q42101206
MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation.Q42607801
The AID enzyme induces class switch recombination in fibroblastsQ42818062
Constitutive expression of AID leads to tumorigenesisQ42944928
Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients.Q43275641
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutationQ44486460
Expression of the AID protein in normal and neoplastic B cellsQ45013739
AID is required for c-myc/IgH chromosome translocations in vivoQ45021537
Methylation protects cytidines from AID-mediated deaminationQ45193401
Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processesQ45723289
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.Q46255308
Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancersQ46437306
Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinomaQ46729038
Comment on "Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjogren's synQ46771620
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombinationQ46821758
AID is required for germinal center-derived lymphomagenesisQ46861217
Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig GenesQ47982616
A hyperconversion mechanism generates the chicken light chain preimmune repertoireQ48349399
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domainsQ51830570
A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutationQ52594560
Chromosome translocations: dangerous liaisons revisitedQ53391539
Aberrant expression and mutation-inducing activity of AID in human lung cancerQ54389595
Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA PolymeraseQ58424602
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocationsQ33588393
Attracting AID to targets of somatic hypermutationQ33656131
Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humansQ33829729
Repression of human activation induced cytidine deaminase by miR-93 and miR-155.Q33989467
GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.Q34025211
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemiaQ34099472
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.Q34147986
Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemiaQ34168766
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cellsQ34188845
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombinationQ34217718
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cellsQ34249818
Boveri and the early days of geneticsQ34295660
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.Q34340626
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5Q34357060
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genesQ34394298
Mechanisms of chromosomal translocations in B cell lymphomasQ34405423
Mechanism and control of class-switch recombinationQ34500935
Molecular mechanism of class switch recombination: linkage with somatic hypermutationQ34542246
Targeting of somatic hypermutationQ34551108
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylationQ34695460
Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinomaQ34698277
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activityQ34748194
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Q34922043
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.Q35060760
Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombinationQ35105143
Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Q35137494
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.Q35144590
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytesQ35304991
Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A)Q35546818
Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNAQ35589869
Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations.Q35675002
Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1Q35709088
Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell LymphomaQ35961549
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.Q36146840
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.Q36229720
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Q36248087
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig lociQ36322298
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cellsQ36327408
The balance between Pax5 and Id2 activities is the key to AID gene expressionQ36371814
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regionsQ36399387
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouseQ36403507
Immunoglobulin class-switch DNA recombination: induction, targeting and beyondQ36534234
Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.Q36634895
Proteasomal degradation restricts the nuclear lifespan of AIDQ36699771
Functional requirements of AID's higher order structures and their interaction with RNA-binding proteinsQ36710679
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regionsQ36842394
AID-initiated purposeful mutations in immunoglobulin genesQ36845671
Evolution of the immunoglobulin heavy chain class switch recombination mechanismQ36845675
Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritisQ36908127
Multiple transcription factor binding sites predict AID targeting in non-Ig genesQ36946108
Regulation of class switch recombination and somatic mutation by AID phosphorylationQ36946561
Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AIDQ36973654
Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cellsQ37001985
Germinal centres: role in B-cell physiology and malignancyQ37039584
Estrogen directly activates AID transcription and functionQ37061875
A Critical Context-Dependent Role for E Boxes in the Targeting of Somatic HypermutationQ37075949
Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stabilityQ37106800
Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.Q37143544
AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4Q37146254
Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous CarcinogenesisQ37217999
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocationsQ37269390
A role for host activation-induced cytidine deaminase in innate immune defense against KSHV.Q37288983
S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombinationQ37292763
Post-translational regulation of activation-induced cytidine deaminaseQ37326092
Avian B-cell development: generation of an immunoglobulin repertoire by gene conversionQ37357847
A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.Q37371679
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiledQ37512363
P304page(s)1-20
P577publication date2017-09-21
P1433published inInternational Reviews of ImmunologyQ6052764
P1476titleAID Biology: A pathological and clinical perspective

Reverse relations

Q52583325Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymuscites workP2860

Search more.