| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0065-2776(06)94005-X |
| P698 | PubMed publication ID | 17560274 |
| P2093 | author name string | Floyd E Romesberg | |
| Myron F Goodman | |||
| Matthew D Scharff | |||
| P2860 | cites work | Harmful somatic mutations: lessons from the dark side | Q74591455 |
| The energy landscape in non-biological and biological molecules | Q77221293 | ||
| A very high level of crossreactivity is an essential feature of the T-cell receptor | Q77324273 | ||
| Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation | Q77671490 | ||
| Regulation of IgG antibody responses by epitope density and CD21-mediated costimulation | Q78852123 | ||
| Histone modifications associated with somatic hypermutation | Q80416565 | ||
| Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) | Q24290325 | ||
| Somatic hypermutation of the AID transgene in B and non-B cells | Q24535846 | ||
| How do site-specific DNA-binding proteins find their targets? | Q24563835 | ||
| Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution | Q24605184 | ||
| Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations | Q24678876 | ||
| Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase | Q24683335 | ||
| Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement | Q27621104 | ||
| A comparative analysis of the immunological evolution of antibody 28B4 | Q27634671 | ||
| Antibody multispecificity mediated by conformational diversity | Q27640592 | ||
| The APOBEC-2 crystal structure and functional implications for the deaminase AID | Q27643398 | ||
| An autoantibody to single-stranded DNA: Comparison of the three-dimensional structures of the unliganded fab and a deoxynucleotide-fab complex | Q27644751 | ||
| Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A | Q27683802 | ||
| Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex | Q27732167 | ||
| The immunological evolution of catalysis | Q27732600 | ||
| 1.85 A structure of anti-fluorescein 4-4-20 Fab | Q27732718 | ||
| Structural insights into the evolution of an antibody combining site | Q27738883 | ||
| Immunological origins of binding and catalysis in a Diels-Alderase antibody | Q27748932 | ||
| Solvent accessibility of the phycocyanobilin chromophore in the alpha subunit of C-phycocyanin: implications for a molecular mechanism for inertial protein-matrix solvation dynamics | Q73800049 | ||
| Transcription-targeted DNA deamination by the AID antibody diversification enzyme | Q28190732 | ||
| AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification | Q28208979 | ||
| Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas | Q28217205 | ||
| Class-switch recombination: interplay of transcription, DNA deamination and DNA repair | Q28269740 | ||
| Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells | Q28509339 | ||
| Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation | Q28586304 | ||
| Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification | Q28589828 | ||
| Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme | Q29547201 | ||
| The Energy Landscapes and Motions of Proteins | Q29616408 | ||
| Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome | Q29618742 | ||
| Molecular Architecture and Biological Reactions | Q30052248 | ||
| How soft is a protein? A protein dynamics force constant measured by neutron scattering. | Q30326855 | ||
| Probing the human natural autoantibody repertoire using an immunoscreening approach | Q30917114 | ||
| Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations | Q31034789 | ||
| Replication protein A interacts with AID to promote deamination of somatic hypermutation targets | Q31099047 | ||
| Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process | Q33198930 | ||
| The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation | Q33226024 | ||
| Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics | Q33256448 | ||
| Genome-wide somatic hypermutation | Q33905110 | ||
| Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells | Q33920280 | ||
| Autoimmunity versus horror autotoxicus: the struggle for recognition | Q33940154 | ||
| Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination | Q33950143 | ||
| APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation | Q34001437 | ||
| A two-phase model of B-cell activation | Q34067352 | ||
| Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. | Q34147986 | ||
| PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells | Q34249818 | ||
| The generation of antibody diversity through somatic hypermutation and class switch recombination | Q34289941 | ||
| Mechanisms of chromosomal translocations in B cell lymphomas | Q34405423 | ||
| Targeting of somatic hypermutation | Q34551108 | ||
| Involvement of Rad18 in somatic hypermutation | Q34551859 | ||
| Monomeric APOBEC3G is catalytically active and has antiviral activity. | Q34647942 | ||
| Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation | Q34695460 | ||
| Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). | Q34922043 | ||
| Molecular recognition in antibody-antigen complexes | Q35014313 | ||
| What role for AID: mutator, or assembler of the immunoglobulin mutasome? | Q35164207 | ||
| AID: how does it aid antibody diversity? | Q35800376 | ||
| Conformational isomerism and the diversity of antibodies | Q35851135 | ||
| Reward versus risk: DNA cytidine deaminases triggering immunity and disease | Q36050458 | ||
| Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin | Q36261566 | ||
| Immunoglobulin gene diversification | Q36312189 | ||
| Error-prone candidates vie for somatic mutation | Q36368573 | ||
| Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies | Q36370217 | ||
| AID mediates hypermutation by deaminating single stranded DNA. | Q36370366 | ||
| H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation | Q36370913 | ||
| Inducible DNA breaks in Ig S regions are dependent on AID and UNG | Q36402801 | ||
| A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination | Q36403922 | ||
| Switching on chromosomal translocations | Q36567140 | ||
| Protein dynamics and the immunological evolution of molecular recognition. | Q37094819 | ||
| Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled | Q37512363 | ||
| Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching | Q37593556 | ||
| Intrinsic and extrinsic factors in protein antigenic structure | Q38151120 | ||
| Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication | Q39079333 | ||
| The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially | Q39645618 | ||
| Conformational substates in proteins | Q39653528 | ||
| APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA. | Q40290523 | ||
| AID-dependent histone acetylation is detected in immunoglobulin S regions | Q40328411 | ||
| Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase | Q40515192 | ||
| Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin | Q40625542 | ||
| C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. | Q40627624 | ||
| Clonal selection and learning in the antibody system | Q41002744 | ||
| Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches | Q41062370 | ||
| The targeting of somatic hypermutation | Q41062380 | ||
| The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination | Q41493193 | ||
| AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts | Q42813803 | ||
| Separate domains of AID are required for somatic hypermutation and class-switch recombination | Q42828095 | ||
| Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation | Q42944652 | ||
| Constitutive expression of AID leads to tumorigenesis | Q42944928 | ||
| Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation | Q44486460 | ||
| Transcription-coupled events associating with immunoglobulin switch region chromatin | Q44699066 | ||
| Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination | Q44811129 | ||
| Structural evidence for induced fit as a mechanism for antibody-antigen recognition | Q45203554 | ||
| MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification | Q46802323 | ||
| Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma | Q47952619 | ||
| Why do B cells mutate their immunoglobulin receptors? | Q51981357 | ||
| Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. | Q55034838 | ||
| Identification of a specific domain required for dimerization of activation-induced cytidine deaminase | Q56749508 | ||
| Codon bias targets mutation. | Q59081204 | ||
| DNA deaminases AID and APOBEC3G act processively on single-stranded DNA | Q61762218 | ||
| Evolutionary chemistry: getting there from here | Q73474945 | ||
| P304 | page(s) | 127-155 | |
| P577 | publication date | 2007-01-01 | |
| P1433 | published in | Advances in Immunology | Q15752932 |
| P1476 | title | AID-initiated purposeful mutations in immunoglobulin genes | |
| P478 | volume | 94 |
| Q28590572 | ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells |
| Q41995688 | AID Biology: A pathological and clinical perspective |
| Q37730711 | APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition |
| Q33575712 | Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation |
| Q34096649 | Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies |
| Q24646317 | Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications |
| Q90057553 | Current insights into the mechanism of mammalian immunoglobulin class switch recombination |
| Q37063328 | DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis |
| Q36499037 | Does antisense make sense of AID targeting? |
| Q90485699 | Effects of senataxin and RNA exosome on B-cell chromosomal integrity |
| Q36969535 | Endogenous mutagenesis in recombinant sulfolobus plasmids |
| Q33379345 | Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase |
| Q36845675 | Evolution of the immunoglobulin heavy chain class switch recombination mechanism |
| Q27486411 | Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein |
| Q37022515 | High-fidelity correction of genomic uracil by human mismatch repair activities |
| Q43244319 | Hypermutation at A/T sites during G.U mismatch repair in vitro by human B-cell lysates |
| Q33328760 | Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase |
| Q51041546 | Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry. |
| Q36137498 | Protein dynamics and the diversity of an antibody response. |
| Q33989467 | Repression of human activation induced cytidine deaminase by miR-93 and miR-155. |
| Q35760853 | Sequential class switching is required for the generation of high affinity IgE antibodies |
| Q28512692 | The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA |
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