| scholarly article | Q13442814 |
| P50 | author | Pietro Roversi | Q28039121 |
| P2093 | author name string | Dan S Tawfik | |
| Leo C James | |||
| P433 | issue | 5611 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | antibody | Q79460 |
| P304 | page(s) | 1362-7 | |
| P577 | publication date | 2003-02-28 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Antibody multispecificity mediated by conformational diversity | |
| P478 | volume | 299 |
| Q33941047 | "Rational vaccine design" for HIV should take into account the adaptive potential of polyreactive antibodies |
| Q28242677 | 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues |
| Q27670852 | A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches |
| Q35850974 | A comprehensive calorimetric investigation of an entropically driven T cell receptor-peptide/major histocompatibility complex interaction |
| Q92546283 | A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins |
| Q47974592 | A multispecific monoclonal antibody G2 recognizes at least three completely different epitope sequences with high affinity |
| Q33224274 | A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex |
| Q24630803 | A new clustering of antibody CDR loop conformations |
| Q97539420 | A pan-specific antiserum produced by a novel immunization strategy shows a high spectrum of neutralization against neurotoxic snake venoms |
| Q28478319 | A role for both conformational selection and induced fit in ligand binding by the LAO protein |
| Q47853083 | A role for macromolecular crowding in off-target binding of therapeutic antibodies |
| Q43065725 | A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammation. |
| Q33784415 | A single intermolecular contact mediates intramolecular stabilization of both RNA and protein |
| Q27663286 | A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey |
| Q39722399 | AB-Bind: Antibody binding mutational database for computational affinity predictions. |
| Q36845671 | AID-initiated purposeful mutations in immunoglobulin genes |
| Q38562942 | Adaptability of protein structures to enable functional interactions and evolutionary implications |
| Q34476441 | Adapters in the organization of mast cell signaling |
| Q35726067 | Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer |
| Q47567087 | Allosteric control of antibody-prion recognition through oxidation of a disulfide bond between the CH and CL chains |
| Q37795355 | Allostery and population shift in drug discovery |
| Q90485061 | An array of 60,000 antibodies for proteome-scale antibody generation and target discovery |
| Q37511760 | An enzymatic molten globule: efficient coupling of folding and catalysis. |
| Q27652490 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase |
| Q47182942 | Ancient phylogenetic beginnings of immunoglobulin hypermutation. |
| Q50628062 | Anti-Aβ antibody target engagement: a response to Siemers et al. |
| Q28294789 | Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases |
| Q92538007 | Anti-Myelin Proteolipid Protein Peptide Monoclonal Antibodies Recognize Cell Surface Proteins on Developing Neurons and Inhibit Their Differentiation |
| Q41172450 | Antibodies as a model system for comparative model refinement. |
| Q100750475 | Antibodies exhibit multiple paratope states influencing VH-VL domain orientations |
| Q33197101 | Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes |
| Q59072047 | Antibodies with a split personality |
| Q91808144 | Antibody Structure and Function: The Basis for Engineering Therapeutics |
| Q33259491 | Antibody binding loop insertions as diversity elements |
| Q33256448 | Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics |
| Q90026464 | Antibody humanization-the Influence of the antibody framework on the CDR-H3 loop ensemble in solution |
| Q26801316 | Antibody promiscuity: Understanding the paradigm shift in antigen recognition |
| Q34247281 | Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping |
| Q57091218 | Antibody validation: a view from the mountains |
| Q36106473 | Antigen-driven induction of polyreactive IgM during intracellular bacterial infection |
| Q36103219 | Antigen-independent effects of immunoglobulin E. |
| Q38439338 | B cells generated by B-1 development can progress to chronic lymphocytic leukemia |
| Q33817798 | BINANA: a novel algorithm for ligand-binding characterization |
| Q30379344 | Back to the Future: Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins. |
| Q33239178 | Bacterial display using circularly permuted outer membrane protein OmpX yields high affinity peptide ligands |
| Q38025633 | Basic research in HIV vaccinology is hampered by reductionist thinking |
| Q35065055 | Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases |
| Q31007864 | Binders Based on Dimerised Immunoglobulin VH Domains |
| Q42702975 | Binding affinities controlled by shifting conformational equilibria: opportunities and limitations |
| Q33284945 | Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies |
| Q27667249 | Biochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal Antibody |
| Q38248878 | Biological messiness vs. biological genius: Mechanistic aspects and roles of protein promiscuity |
| Q34311852 | Biophysics of protein evolution and evolutionary protein biophysics |
| Q91341257 | Breaking the law: unconventional strategies for antibody diversification |
| Q27675388 | CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies |
| Q92427148 | CDR-H3 loop ensemble in solution - conformational selection upon antibody binding |
| Q60919457 | Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties |
| Q37478039 | Chemical control over immune recognition: a class of antibody-recruiting small molecules that target prostate cancer |
| Q88951235 | Chemical cross-linking in the structural analysis of protein assemblies |
| Q30558517 | Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes |
| Q30366590 | Compensatory evolution of a WW domain variant lacking the strictly conserved Trp residue. |
| Q42108234 | Composition of the immunoglobulin classic antigen-binding site regulates allergic airway inflammation in a murine model of experimental asthma. |
| Q64103844 | Computational design of structured loops for new protein functions |
| Q39027224 | Computational protein design with backbone plasticity |
| Q36254449 | Computer-aided antibody design |
| Q27664241 | Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity |
| Q27646623 | Conformational Dynamics and Structural Plasticity Play Critical Roles in the Ubiquitin Recognition of a UIM Domain |
| Q27650346 | Conformational Isomerism Can Limit Antibody Catalysis |
| Q42872555 | Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis |
| Q37272711 | Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes |
| Q73702393 | Conformational diversity and protein evolution--a 60-year-old hypothesis revisited |
| Q27678806 | Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling |
| Q35972988 | Conformational dynamics in loop swap mutants of homologous fibronectin type III domains |
| Q30354087 | Conformational dynamics of individual antibodies using computational docking and AFM. |
| Q54335575 | Conformational selection and induced changes along the catalytic cycle of Escherichia coli dihydrofolate reductase. |
| Q37428879 | Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin |
| Q26864698 | Conformational selection in protein binding and function |
| Q90148769 | Cooperative dynamics of proteins unraveled by network models |
| Q31172558 | Cross-reactivity and conformational multiplicity of an anti-polycyclic aromatic hydrocarbon mAb |
| Q27644303 | Crystal Structures of a Quorum-quenching Antibody |
| Q36141544 | Cytokinergic IgE Action in Mast Cell Activation |
| Q36818986 | Decoding IgE Fc receptors |
| Q33993746 | Designed divergent evolution of enzyme function |
| Q42142843 | Development of antibody arrays for monoclonal antibody Higher Order Structure analysis |
| Q33840423 | Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes |
| Q28484318 | Differential dynamic engagement within 24 SH3 domain: peptide complexes revealed by co-linear chemical shift perturbation analysis |
| Q34187368 | Direct discrimination between models of protein activation by single-molecule force measurements |
| Q35828141 | Directed evolution of human scFvs in DT40 cells. |
| Q33655583 | Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model |
| Q37087355 | Disorder transitions and conformational diversity cooperatively modulate biological function in proteins. |
| Q34419108 | Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target? |
| Q40353620 | Dual specificity of anti-CXCL10-CXCL9 antibodies is governed by structural mimicry |
| Q30399262 | Dynamic New World: Refining Our View of Protein Structure, Function and Evolution |
| Q36837448 | Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms |
| Q24652819 | Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex |
| Q34650980 | Engineered antibody fragments and the rise of single domains |
| Q35605100 | Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme |
| Q79328145 | Epitope mapping of pneumococcal surface protein A of strain Rx1 using monoclonal antibodies and molecular structure modelling |
| Q36689929 | Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. |
| Q57685946 | Evolution AfterandBefore Gene Duplication? |
| Q34450109 | Evolving concepts of specificity in immune reactions |
| Q34197530 | Expanding the proteome: disordered and alternatively folded proteins |
| Q33742973 | Exploring antibody recognition of sequence space through random-sequence peptide microarrays |
| Q41220497 | Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding |
| Q82492155 | Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers |
| Q28588375 | FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation |
| Q34909306 | FiberDock: Flexible induced-fit backbone refinement in molecular docking |
| Q36983081 | Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases |
| Q38077741 | Flexibility and reactivity in promiscuous enzymes |
| Q46980177 | Flow-through partial-filling affinity capillary electrophoresis using a crossreactive antibody for enantiomeric separations |
| Q38793428 | From IgE to Omalizumab |
| Q24621007 | From combinatorial peptide selection to drug prototype (II): targeting the epidermal growth factor receptor pathway |
| Q34313181 | From deep sequencing to actual clones |
| Q34116945 | Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity |
| Q30375717 | Functional aspects of protein flexibility. |
| Q22061730 | Fuzziness: linking regulation to protein dynamics |
| Q36296236 | Generating Conformation and Complex-Specific Synthetic Antibodies |
| Q35679824 | Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells |
| Q27651991 | Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus |
| Q35794935 | Glycosylation of prion strains in transmissible spongiform encephalopathies |
| Q40468637 | Herpesvirus saimiri immortalization of Aotus T lymphocytes specific for an immunogenically modified peptide of Plasmodium falciparum merozoite surface antigen 2. |
| Q30157152 | Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations |
| Q27349722 | High affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticity |
| Q34482369 | High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation |
| Q28257550 | High-affinity binders selected from designed ankyrin repeat protein libraries |
| Q35556797 | Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4. |
| Q28073905 | How relevant is panallergen sensitization in the development of allergies? |
| Q28554216 | How to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation Rates |
| Q38618790 | How to assess the binding strength of antibodies elicited by vaccination against HIV and other viruses |
| Q34699688 | Human germline antibody gene segments encode polyspecific antibodies |
| Q37995555 | Human poly- and cross-reactive anti-viral antibodies and their impact on protection and pathology |
| Q33977808 | Identification and characterization of a multispecific monoclonal antibody G2 against chicken prion protein |
| Q34232022 | Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies. |
| Q35211434 | Identification of aggregation inhibitors of the human antibody light chain repertoire by phage display |
| Q33469751 | Identification of neutralizing conformational epitopes on the human papillomavirus type 31 major capsid protein and functional implications |
| Q36458429 | Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. |
| Q31022558 | Identification of the B-cell epitopes of the early endosome antigen 1 (EEA1). |
| Q41421207 | IgE Trimers Drive SPE-7 Cytokinergic Activity |
| Q36284901 | IgE and FcepsilonRI regulation |
| Q33915536 | IgE-binding epitopes: a reappraisal |
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| Q35969898 | Immunopotentiating properties of a multispecific α-anti-idiotype antibody |
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| Q36819937 | Insights into immunoglobulin E receptor signaling from structurally defined ligands |
| Q49956907 | Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing. |
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| Q37006858 | Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation |
| Q38594356 | Isometrically invariant and allosterically aware description of deformable macromolecular surfaces: Application to the viral neuraminidase |
| Q34130178 | Kinetic rate constant prediction supports the conformational selection mechanism of protein binding |
| Q36393125 | Ligand binding and allostery can emerge simultaneously |
| Q37910841 | Limitations to the structure-based design of HIV-1 vaccine immunogens |
| Q98771873 | Local and Global Rigidification Upon Antibody Affinity Maturation |
| Q55280565 | Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding. |
| Q34483396 | Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance |
| Q35477596 | Mechanism of the antigen-independent cytokinergic SPE-7 IgE activation of human mast cells in vitro |
| Q47565290 | Mechanisms of recognition of amyloid-β (Aβ) monomer, oligomer, and fibril by homologous antibodies |
| Q41829039 | Microsecond timescale backbone conformational dynamics in ubiquitin studied with NMR R1rho relaxation experiments |
| Q30397954 | Mining electron density for functionally relevant protein polysterism in crystal structures |
| Q36812496 | Minute time scale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitope |
| Q27335863 | Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer |
| Q37405719 | Molecular Mechanism and Energy Basis of Conformational Diversity of Antibody SPE7 Revealed by Molecular Dynamics Simulation and Principal Component Analysis |
| Q33490629 | Molecular dynamics simulation of phosphorylated KID post-translational modification |
| Q51091171 | Molecular dynamics simulations elucidate conformational selection and induced fit mechanisms in the binding of PD-1 and PD-L1. |
| Q35829041 | Molecular evolution of affinity and flexibility in the immune system |
| Q27643327 | Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin |
| Q36393520 | Molecular plasticity of beta-catenin: new insights from single-molecule measurements and MD simulation |
| Q36922576 | Monoclonal antibodies - a proven and rapidly expanding therapeutic modality for human diseases |
| Q38633596 | Monoclonal antibodies: technologies for early discovery and engineering |
| Q36341609 | Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens |
| Q28914723 | Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility |
| Q35173705 | Multidisciplinary experimental approaches to characterizing biomolecular dynamics. |
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| Q54549089 | Multiple drugs and multiple targets: an analysis of the electrostatic determinants of binding between non-nucleoside HIV-1 reverse transcriptase inhibitors and variants of HIV-1 RT. |
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| Q35925878 | NKG2D and Related Immunoreceptors |
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| Q38352429 | Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins |
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| Q35725321 | Plasmodium riboprotein PfP0 induces a deviant humoral immune response in Balb/c mice |
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| Q37094819 | Protein dynamics and the immunological evolution of molecular recognition. |
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| Q36179862 | Sequence evolution correlates with structural dynamics |
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| Q27647966 | Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding |
| Q34412591 | Small molecule mimetics of an HIV-1 gp41 fusion intermediate as vaccine leads |
| Q37952285 | Smarter drugs: a focus on pan-specific monoclonal antibodies |
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| Q36360999 | Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space |
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| Q38256188 | Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition |
| Q40954355 | Spot peptide arrays and SPR measurements: throughput and quantification in antibody selectivity studies |
| Q33721429 | Statistical analysis and molecular dynamics simulations of ambivalent α-helices. |
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| Q38050477 | Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism |
| Q27665020 | Structural and thermodynamic analysis of the GFP:GFP-nanobody complex |
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| Q27694801 | Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site |
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| Q35305255 | The intrinsically disordered regions of the Drosophila melanogaster Hox protein ultrabithorax select interacting proteins based on partner topology |
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| Q38612234 | The uncoupled ATPase activity of the ABC transporter BtuC2D2 leads to a hysteretic conformational change, conformational memory, and improved activity |
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