The balance between Pax5 and Id2 activities is the key to AID gene expression

scientific article

The balance between Pax5 and Id2 activities is the key to AID gene expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20030802
P932PMC publication ID2194241
P698PubMed publication ID14581609
P5875ResearchGate publication ID5402146

P50authorTomoya KatakaiQ58338285
Manabu SugaiQ126200547
P2093author name stringYasutoshi Agata
Akira Shimizu
Hiroyuki Gonda
Yoshifumi Yokota
Yukiko Nambu
Kazuhiro J Mori
P2860cites workId helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factorsQ24533584
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cellsQ24534351
Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA bindingQ24551030
Helix-loop-helix proteins: regulators of transcription in eucaryotic organismsQ24554353
The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexesQ24554523
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression programQ28216493
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomasQ28217205
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangementsQ28243194
The helix-loop-helix gene E2A is required for B cell formationQ28504830
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cellsQ28509339
TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient miceQ28509342
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.Q33854381
Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptorQ33873924
Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cellsQ34282966
Role of Id family proteins in growth controlQ34504481
Molecular mechanism of class switch recombination: linkage with somatic hypermutationQ34542246
Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase.Q34656270
Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switchingQ40793070
Dissociation of Pax-5 from KI and KII sites during kappa-chain gene rearrangement correlates with its association with the underphosphorylated form of retinoblastomaQ40804900
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell lineQ41007894
Analysis of chromatin structure by in vivo formaldehyde cross-linking.Q41132202
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombinationQ41702555
Episomal vectors rapidly and stably produce high-titer recombinant retrovirusQ42810400
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblastsQ42813803
The AID enzyme induces class switch recombination in fibroblastsQ42818062
Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms.Q42830538
E-proteins directly regulate expression of activation-induced deaminase in mature B cellsQ44419402
Id helix-loop-helix proteins in cell growth and differentiationQ47721621
OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activityQ47888779
Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.Q51065317
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAPQ58326934
Constitutive expression of the Id1 gene impairs mouse B cell developmentQ71988116
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cellsQ74548133
Essential role of Id2 in negative regulation of IgE class switchingQ78665388
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1427-1437
P577publication date2003-10-27
P1433published inJournal of Experimental MedicineQ3186912
P1476titleThe balance between Pax5 and Id2 activities is the key to AID gene expression
P478volume198

Reverse relations

cites work (P2860)
Q35890025A Network Model to Describe the Terminal Differentiation of B Cells
Q33605445A coming-of-age story: activation-induced cytidine deaminase turns 10.
Q34994891A critical role of the Thy28-MYH9 axis in B cell-specific expression of the Pax5 gene in chicken B cells
Q39924635A novel pax5-binding regulatory element in the igκ locus
Q41995688AID Biology: A pathological and clinical perspective
Q34118000AID and somatic hypermutation.
Q64086097AID modulates carcinogenesis network via DNA demethylation in bladder urothelial cell carcinoma
Q28085553AID/APOBEC deaminases and cancer
Q39245074APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.
Q37045143APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells.
Q30855570Aberrant expression of ID2 protein and its correlation with EBV-LMP1 and P16(INK4A) in classical Hodgkin lymphoma in China
Q35607200Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma
Q39640071Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis
Q37351651Activation of Aicda gene transcription by Pax5 in plasmacytoma cells
Q36592764Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.
Q37088708Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells.
Q34044904Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component
Q38302008Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells
Q24297331Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression
Q37994933Activation-induced cytidine deaminase in antibody diversification and chromosome translocation
Q54398626Activation-induced cytidine deaminase mRNA levels in chronic lymphocytic leukemia.
Q36508536Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion
Q30436993Affinity of antigen encounter and other early B-cell signals determine B-cell fate
Q35806803Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues
Q40128287Aiolos controls gene conversion and cell death in DT40 B cells
Q38334286Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation
Q36714911Alum Directly Modulates Murine B Lymphocytes to Produce IgG1 Isotype
Q37280181Augmentation of antibody responses by retinoic acid and costimulatory molecules
Q38348243B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
Q36446170B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins
Q42171084Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch
Q39500310Bcl6: where too much complexity is barely enough
Q50993571Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.
Q36769461Class switch recombination: a comparison between mouse and human.
Q36316915Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications
Q38036378Current concepts of IgE regulation and impact of genetic determinants.
Q36015019DNA deamination in immunity
Q36403618Differential requirement for OBF-1 during antibody-secreting cell differentiation
Q36949937Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.
Q37087320E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification
Q26772330Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response
Q39202093Epstein-Barr virus latent membrane protein 1 increases genomic instability through Egr-1-mediated up-regulation of activation-induced cytidine deaminase in B-cell lymphoma
Q37061875Estrogen directly activates AID transcription and function
Q33947867Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination
Q28235340First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies
Q37851178Gene interaction network regulates plasma cell differentiation.
Q37039584Germinal centres: role in B-cell physiology and malignancy
Q36292892Helix-loop-helix proteins and lymphocyte development
Q38062548Hormones and AID: balancing immunity and autoimmunity
Q24645030HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation
Q47108872IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression.
Q79755765IRF4 - a factor for class switching and antibody secretion
Q90379883Impaired B Cell Function in Mice Lacking Perforin-2
Q34684380In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression
Q36402801Inducible DNA breaks in Ig S regions are dependent on AID and UNG
Q40337542Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Q64067953Macrophage-B Cell Interactions in the Inverted Porcine Lymph Node and Their Response to Porcine Reproductive and Respiratory Syndrome Virus
Q39618298Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP-1 pathways
Q36037736Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences
Q34764888Mechanism and regulation of class switch recombination
Q24653222MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
Q24646923MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
Q35988449MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals
Q35488455Mitochondrial function provides instructive signals for activation-induced B-cell fates
Q26768663Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity
Q38239866Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network
Q39122684Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses
Q36570655Pax5--a critical inhibitor of plasma cell fate
Q36399312Plasma cell ontogeny defined by quantitative changes in blimp-1 expression
Q37704005Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity
Q42826566RFX1 mediates the serum-induced immediate early response of Id2 gene expression
Q33513975Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.
Q24791043Regulation of Id2 expression by CCAAT/enhancer binding protein beta
Q24633098Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination
Q36946561Regulation of class switch recombination and somatic mutation by AID phosphorylation
Q34695460Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation
Q34115234Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair
Q36058417Regulation of plasma-cell development
Q34122312Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development
Q37419452Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes
Q36845685Role of AID in tumorigenesis
Q35797150Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies
Q35978867Somatic hypermutation: a mutational panacea
Q34099472The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia
Q28306121The ID proteins: master regulators of cancer stem cells and tumour aggressiveness
Q24678497The IRF family, revisited
Q58762992The Transcriptional Regulation of Germinal Center Formation
Q54627211The chicken Ig light chain 3'-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A.
Q38002486The diverse roles of IRF4 in late germinal center B-cell differentiation
Q40034606The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas
Q36999672The regulation of the B-cell gene expression programme by Pax5.
Q38271843The role of Pax5 in leukemia: diagnosis and prognosis significance.
Q36845661The role of activation-induced deaminase in antibody diversification and chromosome translocations
Q51981842Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.
Q100465086Transcriptional regulation of memory B cell differentiation
Q35843852Unique maturation program of the IgE response in vivo
Q36229720Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.
Q37677543Walking the AID tightrope
Q37061884Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase?
Q88400647Zinc finger-IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell

Search more.