A novel pax5-binding regulatory element in the igκ locus

scientific article published on 23 May 2014

A novel pax5-binding regulatory element in the igκ locus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FIMMU.2014.00240
P932PMC publication ID4033077
P698PubMed publication ID24904588
P5875ResearchGate publication ID262927906

P2093author name stringHoward Cedar
Yehudit Bergman
Rena Levin-Klein
Chaggai Rosenbluh
Andrei Kirillov
P2860cites workHydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brainQ24299862
E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cellsQ24301680
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1Q24316558
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
Detection of specific sequences among DNA fragments separated by gel electrophoresisQ25939003
Developmentally controlled and tissue-specific expression of unrearranged VH gene segmentsQ28259020
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformationQ28508217
Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoterQ28511253
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in miceQ28511594
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignanciesQ28591763
Transfection Using DEAE-DextranQ29028334
BSAP can repress enhancer activity by targeting PU.1 functionQ33786904
Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sitesQ34161702
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteinsQ34376497
Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoterQ34382768
Targeting of somatic hypermutationQ34551108
V(D)J recombination: RAG proteins, repair factors, and regulationQ34667417
The Igκ gene enhancers, E3' and Ed, are essential for triggering transcriptionQ34686905
Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cellsQ35067918
Kappa chain monoallelic demethylation and the establishment of allelic exclusionQ35202527
A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expressionQ35803016
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylationQ36008141
Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk lociQ36228744
The balance between Pax5 and Id2 activities is the key to AID gene expressionQ36371814
Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell developmentQ36376789
Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangementQ36399353
A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancerQ36560382
The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutationQ36713840
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.Q37137057
The colorful history of active DNA demethylation.Q37201774
DNMT1-interacting RNAs block gene-specific DNA methylationQ37408576
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencersQ38348243
Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanisms for controlling V(D)J cleavageQ38351912
Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangementQ38359938
Differential accessibility at the kappa chain locus plays a role in allelic exclusionQ39658922
The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association.Q40455059
The importance of the 3'-enhancer region in immunoglobulin kappa gene expressionQ40524393
Pax-5 is essential for kappa sterile transcription during Ig kappa chain gene rearrangementQ40569701
5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytesQ40593350
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiationQ40617973
Chromatin structural analyses of the mouse Igkappa gene locus reveal new hypersensitive sites specifying a transcriptional silencer and enhancerQ40722898
Dissociation of Pax-5 from KI and KII sites during kappa-chain gene rearrangement correlates with its association with the underphosphorylated form of retinoblastomaQ40804900
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant regionQ40818245
Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.Q41081725
In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activationQ41130580
Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitroQ41191663
B cell-specific demethylation: a novel role for the intronic kappa chain enhancer sequenceQ41481236
Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryosQ41936512
A human immunoglobulin lambda locus is similarly well expressed in mice and humansQ42944671
Immunoglobulin gene transcription is activated by downstream sequence elementsQ43904180
Epigenetic ontogeny of the Igk locus during B cell developmentQ45201947
Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylationQ46053556
Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutationQ46695145
Clonal allelic predetermination of immunoglobulin-κ rearrangement.Q50782638
DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.Q52222420
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locusQ57198208
Contribution of Receptor Editing to the Antibody RepertoireQ57198265
The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytesQ71535980
Pax-5 is identical to EBB-1/KLP and binds to the VpreB and lambda5 promoters as well as the KI and KII sites upstream of the Jkappa genesQ73174934
A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locusQ83161599
P304page(s)240
P577publication date2014-05-23
P1433published inFrontiers in ImmunologyQ27723748
P1476titleA novel pax5-binding regulatory element in the igκ locus
P478volume5

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cites work (P2860)
Q42154732Chromatin and transcriptional tango on the immune dance floor
Q34637706Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes