scholarly article | Q13442814 |
P356 | DOI | 10.1038/NI923 |
P953 | full work available at URL | http://www.nature.com/articles/ni923.pdf |
http://www.nature.com/articles/ni923 | ||
P698 | PubMed publication ID | 12717431 |
P5875 | ResearchGate publication ID | 10786006 |
P50 | author | Cornelis Murre | Q94947744 |
P2093 | author name string | Yasutoshi Agata | |
Melanie W. Quong | |||
Camil Elie Sayegh | |||
P2860 | cites work | Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) | Q24290325 |
Promotion of cell cycle progression by basic helix-loop-helix E2A | Q24291573 | ||
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins | Q24299387 | ||
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence | Q24300878 | ||
Histone-like TAFs within the PCAF histone acetylase complex | Q24317520 | ||
Internal IgH class switch region deletions are position-independent and enhanced by AID expression | Q24535261 | ||
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms | Q24554353 | ||
A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation | Q27936635 | ||
The ATM-related cofactor Tra1 is a component of the purified SAGA complex | Q27937594 | ||
The CBP co-activator is a histone acetyltransferase | Q28131758 | ||
E protein function in lymphocyte development | Q28203458 | ||
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification | Q28208979 | ||
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program | Q28216493 | ||
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements | Q28243194 | ||
The role of E-proteins in B- and T-lymphocyte development | Q28273104 | ||
The helix-loop-helix gene E2A is required for B cell formation | Q28504830 | ||
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells | Q28509339 | ||
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme | Q29547201 | ||
Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals | Q33985264 | ||
Molecular mechanism of class switch recombination: linkage with somatic hypermutation | Q34542246 | ||
Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas | Q34945511 | ||
Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions | Q34997657 | ||
Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus | Q35064395 | ||
E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins | Q36686388 | ||
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene | Q39447043 | ||
Increased transcription levels induce higher mutation rates in a hypermutating cell line | Q40814374 | ||
Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation | Q40858324 | ||
E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells | Q40869804 | ||
Life and death in germinal centers (redux). | Q40983825 | ||
The immunoglobulin class switch: beyond "accessibility". | Q41389958 | ||
Shutdown of class switch recombination by deletion of a switch region control element. | Q41573717 | ||
Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line | Q41672433 | ||
A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex | Q41684988 | ||
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination | Q41702555 | ||
Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination | Q41777608 | ||
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus | Q42810400 | ||
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts | Q42813803 | ||
The AID enzyme induces class switch recombination in fibroblasts | Q42818062 | ||
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation | Q42944652 | ||
Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. | Q42951830 | ||
Both E12 and E47 allow commitment to the B cell lineage | Q45129651 | ||
Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus | Q47788471 | ||
Normal isotype switching in B cells lacking the I mu exon splice donor site: evidence for multiple I mu-like germline transcripts. | Q52171631 | ||
Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching | Q71874702 | ||
Switch transcripts in immunoglobulin class switching | Q72635906 | ||
Ig S gamma-specific DNA binding protein SNAP is related to the helix-loop-helix transcription factor E47 | Q73544343 | ||
Transcription factors in lymphocyte development--T and B cells get together | Q78170515 | ||
Essential role of Id2 in negative regulation of IgE class switching | Q78665388 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | immunology | Q101929 |
P304 | page(s) | 586-593 | |
P577 | publication date | 2003-04-28 | |
P1433 | published in | Nature Immunology | Q1071725 |
P1476 | title | E-proteins directly regulate expression of activation-induced deaminase in mature B cells | |
P478 | volume | 4 |
Q33959475 | 3D trajectories adopted by coding and regulatory DNA elements: first-passage times for genomic interactions |
Q33605445 | A coming-of-age story: activation-induced cytidine deaminase turns 10. |
Q33961160 | A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate |
Q33240316 | A library of gene expression signatures to illuminate normal and pathological lymphoid biology |
Q33509909 | A tamoxifen inducible knock-in allele for investigation of E2A function |
Q33934571 | A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression |
Q34118000 | AID and somatic hypermutation. |
Q30424165 | AID in aging and autoimmune diseases. |
Q64086097 | AID modulates carcinogenesis network via DNA demethylation in bladder urothelial cell carcinoma |
Q28265992 | AID targeting: old mysteries and new challenges |
Q28085553 | AID/APOBEC deaminases and cancer |
Q36104522 | AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer |
Q37045143 | APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells. |
Q35607200 | Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma |
Q37351651 | Activation of Aicda gene transcription by Pax5 in plasmacytoma cells |
Q36592764 | Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers. |
Q38302008 | Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells |
Q24297331 | Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression |
Q37994933 | Activation-induced cytidine deaminase in antibody diversification and chromosome translocation |
Q54398626 | Activation-induced cytidine deaminase mRNA levels in chronic lymphocytic leukemia. |
Q36508536 | Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion |
Q47116886 | Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging |
Q37781581 | Age effects on B cells and humoral immunity in humans |
Q38160778 | Age effects on mouse and human B cells |
Q38868206 | Ageing and obesity similarly impair antibody responses |
Q37841206 | Aging affects human B cell responses |
Q35806803 | Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues |
Q35809431 | Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF |
Q38640148 | Aging, cytomegalovirus (CMV) and influenza vaccine responses |
Q37280181 | Augmentation of antibody responses by retinoic acid and costimulatory molecules |
Q33893517 | B cell TLRs and induction of immunoglobulin class-switch DNA recombination |
Q38348243 | B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers |
Q37398750 | B cells and aging: molecules and mechanisms |
Q36121005 | B cells, E2A, and aging |
Q36446170 | B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins |
Q38050656 | B-lineage transcription factors and cooperating gene lesions required for leukemia development |
Q36970694 | BCR-ABL-transformed GMP as myeloid leukemic stem cells |
Q24632504 | BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway |
Q42171084 | Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch |
Q35943310 | Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. |
Q50993571 | Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. |
Q36769461 | Class switch recombination: a comparison between mouse and human. |
Q24800375 | Cloning and functional characterisation of avian transcription factor E2A |
Q37634047 | Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination |
Q36316915 | Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications |
Q36015019 | DNA deamination in immunity |
Q37185858 | Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation |
Q36949937 | Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development. |
Q41492931 | E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. |
Q36238113 | E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment |
Q38253505 | E proteins in lymphocyte development and lymphoid diseases |
Q37087320 | E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification |
Q83146478 | E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia |
Q37010255 | E2A proteins promote development of lymphoid-primed multipotent progenitors |
Q36455989 | E47 retroviral rescue of intrinsic B-cell defects in senescent mice. |
Q37553468 | Effects of aging on B cell function |
Q37228632 | Effects of fenbendazole on the murine humoral immune system. |
Q38929540 | Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias |
Q37061875 | Estrogen directly activates AID transcription and function |
Q51597552 | Evaluation of the host transcriptional response to human cytomegalovirus infection. |
Q52057625 | Evolution of vertebrate E protein transcription factors: comparative analysis of the E protein gene family in Takifugu rubripes and humans. |
Q33947867 | Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination |
Q28235340 | First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies |
Q33595661 | Functions and regulation of the APOBEC family of proteins |
Q34773120 | Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development |
Q39761197 | Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming |
Q37039584 | Germinal centres: role in B-cell physiology and malignancy |
Q36292892 | Helix-loop-helix proteins and lymphocyte development |
Q34647217 | Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses |
Q24645030 | HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation |
Q41193753 | Id3 Orchestrates Germinal Center B Cell Development. |
Q37164431 | Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues |
Q36534234 | Immunoglobulin class-switch DNA recombination: induction, targeting and beyond |
Q35874111 | Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population. |
Q90136333 | Immunosenescence and human vaccine immune responses |
Q90379883 | Impaired B Cell Function in Mice Lacking Perforin-2 |
Q34684380 | In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression |
Q36290880 | Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells |
Q37323207 | Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A. |
Q36225887 | Inflammaging decreases adaptive and innate immune responses in mice and humans |
Q37527174 | Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. |
Q53606509 | Interleukin-5 regulates genes involved in B-cell terminal maturation. |
Q40337542 | Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma |
Q36033318 | Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination |
Q24317920 | Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent |
Q36037736 | Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences |
Q41445689 | Metformin improves in vivo and in vitro B cell function in individuals with obesity and Type-2 Diabetes |
Q24653222 | MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase |
Q24646923 | MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation |
Q35988449 | MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals |
Q39710239 | Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development |
Q35832501 | Multitasking of helix-loop-helix proteins in lymphopoiesis |
Q36626088 | Obesity decreases B cell responses in young and elderly individuals |
Q33603971 | Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen |
Q37704005 | Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity |
Q35571154 | Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability |
Q36229307 | Regulation of AID expression in the immune response |
Q26853622 | Regulation of Aicda expression and AID activity |
Q24633098 | Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination |
Q36946561 | Regulation of class switch recombination and somatic mutation by AID phosphorylation |
Q34695460 | Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation |
Q34115234 | Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair |
Q34333707 | Regulation of immunoglobulin gene transcription in a teleost fish: identification, expression and functional properties of E2A in the channel catfish |
Q37419452 | Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes |
Q41999588 | Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination |
Q36229482 | Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination. |
Q36845685 | Role of AID in tumorigenesis |
Q35797150 | Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies |
Q24617969 | Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities |
Q35978867 | Somatic hypermutation: a mutational panacea |
Q26766723 | Stable long-term cultures of self-renewing B cells and their applications |
Q44919825 | Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice |
Q36845667 | Targeting of AID-mediated sequence diversification by cis-acting determinants |
Q34099472 | The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia |
Q35011166 | The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells |
Q42777829 | The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development |
Q58762992 | The Transcriptional Regulation of Germinal Center Formation |
Q36371814 | The balance between Pax5 and Id2 activities is the key to AID gene expression |
Q54627211 | The chicken Ig light chain 3'-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A. |
Q38002486 | The diverse roles of IRF4 in late germinal center B-cell differentiation |
Q36845661 | The role of activation-induced deaminase in antibody diversification and chromosome translocations |
Q35555992 | Transcription factors controlling the beginning and end of B-cell differentiation |
Q100465086 | Transcriptional regulation of memory B cell differentiation |
Q36229720 | Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. |
Q37677543 | Walking the AID tightrope |
Q37061884 | Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase? |
Q39780657 | c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma |
Q57036266 | miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1 |