Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory

scientific article published on 29 February 2016

Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.IMMUNI.2016.01.011
P932PMC publication ID4838502
P698PubMed publication ID26944202

P50authorMichel C. NussenzweigQ24804686
Anna GazumyanQ65089949
Alexander D GitlinQ99708568
Lotta von BoehmerQ114408569
Thiago Yukio Kikuchi OliveiraQ56490386
P2093author name stringZiv Shulman
P2860cites workCre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusQ24797230
The role of Fc-FcγR interactions in IgG-mediated microbial neutralizationQ26797466
S1PR2 links germinal center confinement and growth regulationQ26829249
Molecular programming of B cell memoryQ26829944
VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSEQ76969494
A chemokine-driven positive feedback loop organizes lymphoid folliclesQ28142202
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleenQ28300225
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Predominant autoantibody production by early human B cell precursorsQ29619656
Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.Q30371529
Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signalingQ30495504
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporterQ30498133
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinementQ30503547
Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation.Q33733998
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombinationQ33794964
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune responseQ33886727
Germinal centersQ34245271
Antigen receptors on B lymphocytesQ34420640
The generation of antibody-secreting plasma cells.Q34463732
Mature B cells class switched to IgD are autoreactive in healthy individualsQ34629514
The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.Q34677828
Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.Q34681437
Mechanism and regulation of class switch recombinationQ34764888
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populationsQ34885732
Homing of antibody secreting cellsQ35170914
Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutantsQ35627714
Autoreactivity in human IgG+ memory B cellsQ35729131
c-Myb is required for plasma cell migration to bone marrow after immunization or infectionQ35824200
A germinal center-independent pathway generates unswitched memory B cells early in the primary responseQ35825984
Surrogate light chain expressing human peripheral B cells produce self-reactive antibodiesQ35834694
Bone marrow is a major site of long-term antibody production after acute viral infectionQ35835410
The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptorsQ36145652
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin MiceQ36159067
Endogenous antigen tunes the responsiveness of naive B cells but not T cellsQ36223587
High affinity germinal center B cells are actively selected into the plasma cell compartment.Q36228042
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropismQ36228105
Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptorsQ36229232
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/betaQ36229267
Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2Q36268033
lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse lineQ36364512
Gene dose-dependent maturation and receptor editing of B cells expressing immunoglobulin (Ig)G1 or IgM/IgG1 tail antigen receptorsQ36368371
A coordinated change in chemokine responsiveness guides plasma cell movementsQ36369352
Germinal-center organization and cellular dynamicsQ36459345
Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivoQ36642612
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursorsQ36775342
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligationQ36977531
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocationsQ37269390
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory responseQ37322165
Different B cell populations mediate early and late memory during an endogenous immune responseQ37712769
Heterogeneity in the differentiation and function of memory B cellsQ38037738
Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.Q39246618
HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.Q39553791
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cellsQ39814347
Humoral immunity. Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cellQ40019887
C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Q40627624
Clonal selection and learning in the antibody systemQ41002744
Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defenseQ41430473
Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell developmentQ41964652
Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.Q41976378
Clonal selection in the germinal centre by regulated proliferation and hypermutationQ42185336
Dynamic signaling by T follicular helper cells during germinal center B cell selection.Q42406102
AID mutant analyses indicate requirement for class-switch-specific cofactorsQ42798287
Separate domains of AID are required for somatic hypermutation and class-switch recombinationQ42828095
Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissuesQ42830658
Multiple layers of B cell memory with different effector functionsQ43255281
Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigensQ43603650
Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation.Q43744129
A distinct signaling pathway used by the IgG-containing B cell antigen receptorQ44257389
Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition.Q45671838
Duration of humoral immunity to common viral and vaccine antigensQ45872621
Antigen-induced B-cell death and elimination during germinal-centre immune responsesQ46147419
Imaging of germinal center selection events during affinity maturationQ46722429
Diversity among memory B cells: origin, consequences, and utility.Q46918689
Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox VaccinationQ47395264
Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT systemQ47756393
Memory B-cell persistence is independent of persisting immunizing antigen.Q47821945
Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells.Q51983578
Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory.Q52014781
Kinetics of establishing the memory B cell population as revealed by CD38 expression.Q52039439
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.Q52043164
Effect of transmembrane and cytoplasmic domains of IgE on the IgE response.Q52043166
Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.Q52053087
Persistence of memory B cells in mice deprived of T cell help.Q52111523
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)769-781
P577publication date2016-02-29
P1433published inImmunityQ6005457
P1476titleIndependent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory
P478volume44

Reverse relations

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