| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1043591468 |
| P356 | DOI | 10.1038/ONC.2014.375 |
| P698 | PubMed publication ID | 25381821 |
| P5875 | ResearchGate publication ID | 268154066 |
| P50 | author | Alexander Emelyanov | Q59692596 |
| P2093 | author name string | D V Bulavin | |
| P2860 | cites work | The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop | Q24297633 |
| Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair | Q24297983 | ||
| Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner | Q24336721 | ||
| PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints | Q24527393 | ||
| Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization | Q24564349 | ||
| Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer | Q24595803 | ||
| p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation | Q24596239 | ||
| Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway | Q24607221 | ||
| Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications | Q24608343 | ||
| Mutational processes molding the genomes of 21 breast cancers | Q24620915 | ||
| Massive genomic rearrangement acquired in a single catastrophic event during cancer development | Q24631164 | ||
| GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model | Q24657350 | ||
| Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications | Q27860709 | ||
| Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations | Q37703117 | ||
| Processed pseudogenes acquired somatically during cancer development | Q37718241 | ||
| The DNA damage response and cancer therapy | Q37977004 | ||
| Ubiquitin and SUMO in DNA repair at a glance | Q37987407 | ||
| The biology of human breast epithelial progenitors. | Q38011566 | ||
| The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance | Q38037329 | ||
| DNA repair dysregulation from cancer driver to therapeutic target | Q38061847 | ||
| Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the drivers | Q38087850 | ||
| Prolactin actions | Q38153023 | ||
| Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. | Q39037345 | ||
| Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation | Q39077396 | ||
| MicroRNA expression analysis of mammospheres cultured from human breast cancers | Q39321461 | ||
| A small molecule inhibitor of p53-inducible protein phosphatase PPM1D. | Q39437642 | ||
| The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation. | Q39472176 | ||
| The association of HER-2/neu amplification with breast cancer recurrence | Q39554344 | ||
| Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition | Q39747969 | ||
| Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer | Q39766844 | ||
| Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter | Q39805891 | ||
| WIP1 phosphatase is a negative regulator of NF-kappaB signalling | Q39859211 | ||
| The accumulation of specific amplifications characterizes two different genomic pathways of evolution of familial breast tumors | Q81639115 | ||
| The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis | Q82176047 | ||
| Prognostic value of PPM1D in 800 gastric cancer patients | Q87795882 | ||
| Molecular portraits of human breast tumours | Q28032461 | ||
| Multiple genes at 17q23 undergo amplification and overexpression in breast cancer | Q28141301 | ||
| Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23 | Q28218453 | ||
| Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity | Q28218469 | ||
| The DNA damage response: ten years after | Q28261230 | ||
| The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair | Q28278532 | ||
| The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours | Q28279346 | ||
| Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase | Q28283888 | ||
| Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome | Q28283932 | ||
| Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma | Q28284093 | ||
| Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components | Q28290477 | ||
| Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer | Q28388006 | ||
| Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium | Q28513906 | ||
| Tumour evolution inferred by single-cell sequencing | Q28646966 | ||
| Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers | Q28728499 | ||
| Signatures of mutational processes in human cancer | Q29547191 | ||
| Modes of p53 regulation | Q29615657 | ||
| Generation of a functional mammary gland from a single stem cell | Q29616496 | ||
| Supervised risk predictor of breast cancer based on intrinsic subtypes | Q29617404 | ||
| Landscape of somatic retrotransposition in human cancers | Q29617664 | ||
| Active human retrotransposons: variation and disease | Q29617668 | ||
| Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies | Q29617680 | ||
| Rare somatic cells from human breast tissue exhibit extensive lineage plasticity | Q30537989 | ||
| Distinct phosphatases antagonize the p53 response in different phases of the cell cycle | Q30578888 | ||
| Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer | Q30981767 | ||
| The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells | Q33199519 | ||
| Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers | Q33260375 | ||
| The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair | Q33572384 | ||
| Functions and regulation of the APOBEC family of proteins | Q33595661 | ||
| Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis | Q33639152 | ||
| Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase | Q33648301 | ||
| Lineage tracing of mammary epithelial cells using cell-type-specific cre-expressing adenoviruses | Q33729698 | ||
| Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers | Q33731292 | ||
| Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland | Q33739278 | ||
| Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging | Q33808257 | ||
| Oncogene addiction as a foundational rationale for targeted anti‐cancer therapy: promises and perils | Q36038823 | ||
| Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer | Q36323100 | ||
| Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D | Q36326949 | ||
| The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants | Q36490004 | ||
| High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer | Q36610257 | ||
| A new genome-driven integrated classification of breast cancer and its implications | Q36664694 | ||
| Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint | Q36841814 | ||
| Insights into the regulation of protein abundance from proteomic and transcriptomic analyses | Q36846022 | ||
| Hormone-sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium | Q36903215 | ||
| AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations | Q37269390 | ||
| Genetic variation in the chromosome 17q23 amplicon and breast cancer risk | Q37311599 | ||
| Genetic variants and mutations of PPM1D control the response to DNA damage. | Q37396919 | ||
| Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis | Q37426789 | ||
| The current structural and functional understanding of APOBEC deaminases | Q37528123 | ||
| APOBEC3B is an enzymatic source of mutation in breast cancer. | Q37533713 | ||
| PPM1D is a potential therapeutic target in ovarian clear cell carcinomas | Q39871749 | ||
| Downregulation of Wip-1 phosphatase expression in MCF-7 breast cancer cells enhances doxorubicin-induced apoptosis through p53-mediated transcriptional activation of Bax. | Q39880003 | ||
| PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53. | Q40004419 | ||
| Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinoma | Q40096682 | ||
| Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers | Q40245632 | ||
| Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. | Q40263011 | ||
| Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. | Q40269139 | ||
| Genomic and expression profiling of chromosome 17 in breast cancer reveals complex patterns of alterations and novel candidate genes | Q40514744 | ||
| Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer | Q41756399 | ||
| Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response | Q41967616 | ||
| Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer | Q42450903 | ||
| Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers | Q42457867 | ||
| TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance | Q42458495 | ||
| An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers | Q42458622 | ||
| Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer patients | Q42465735 | ||
| Progesterone induces adult mammary stem cell expansion | Q42471079 | ||
| BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells | Q42476392 | ||
| β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation | Q42479900 | ||
| Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer | Q42499457 | ||
| PPM1D is a prognostic marker and therapeutic target in colorectal cancer | Q42718225 | ||
| Heterogeneity in breast cancer | Q42942060 | ||
| PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study | Q43027152 | ||
| Response to DNA damage: why do we need to focus on protein phosphatases? | Q43101429 | ||
| The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. | Q43974233 | ||
| Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice | Q44069585 | ||
| PPM1D as a novel biomarker for prostate cancer after radical prostatectomy | Q44347643 | ||
| Patterns of chromosomal imbalances defines subgroups of breast cancer with distinct clinical features and prognosis. A study of 305 tumors by comparative genomic hybridization. | Q44705934 | ||
| Hormone receptor patterning plays a critical role in normal lobuloalveolar development and breast cancer progression | Q45248775 | ||
| Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets | Q47848630 | ||
| Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice. | Q47937421 | ||
| Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway | Q48022280 | ||
| Stat5a is mandatory for adult mammary gland development and lactogenesis. | Q48055024 | ||
| Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma | Q48324246 | ||
| Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice | Q48348820 | ||
| Dissociation between steroid receptor expression and cell proliferation in the human breast | Q52528046 | ||
| Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer | Q52544495 | ||
| PPM1D is a potential target for 17q gain in neuroblastoma | Q52828743 | ||
| Genetic alterations of the p14ARF -hdm2-p53 regulatory pathway in breast carcinoma | Q53399243 | ||
| The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis | Q53595739 | ||
| Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer. | Q53797466 | ||
| Fibromatosis of the breast and mutations involving the APC/beta-catenin pathway | Q54551283 | ||
| Impact of DNA amplification on gene expression patterns in breast cancer | Q57274809 | ||
| Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification | Q57287598 | ||
| Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways | Q61849111 | ||
| The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase | Q64388322 | ||
| neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group | Q74463760 | ||
| Detection of genetic alterations in bladder tumors by comparative genomic hybridization and cytogenetic analysis | Q77359629 | ||
| Widespread chromosomal abnormalities in high-grade ductal carcinoma in situ of the breast. Comparative genomic hybridization study of pure high-grade DCIS | Q77976509 | ||
| Detection of genetic alterations in advanced prostate cancer by comparative genomic hybridization | Q78365651 | ||
| Prognostic relevance of gene amplifications and coamplifications in breast cancer | Q81085059 | ||
| Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas | Q33813999 | ||
| Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing | Q33839390 | ||
| Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer | Q33860808 | ||
| Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. | Q33888431 | ||
| Abnormality of pl6/p38MAPK/p53/Wipl pathway in papillary thyroid cancer | Q33972927 | ||
| Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response | Q33994571 | ||
| Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells | Q33995584 | ||
| The human LINE-1 retrotransposon creates DNA double-strand breaks. | Q34061457 | ||
| Specific protection against breast cancers by cyclin D1 ablation | Q34082446 | ||
| Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line | Q34133238 | ||
| Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. | Q34146539 | ||
| Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer | Q34233218 | ||
| Regulation of DNA Damage Responses by Ubiquitin and SUMO | Q34328184 | ||
| Long interspersed element-1 (LINE-1): passenger or driver in human neoplasms? | Q34337046 | ||
| Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice | Q34348008 | ||
| Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. | Q34449969 | ||
| Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man. | Q34553577 | ||
| Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation | Q34573593 | ||
| Protein Phosphatase Magnesium-Dependent 1δ (PPM1D) mRNA Expression Is a Prognosis Marker for Hepatocellular Carcinoma | Q34654088 | ||
| The MDM2 gene amplification database | Q34672224 | ||
| Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast | Q34698214 | ||
| Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells | Q34792452 | ||
| Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers | Q35029573 | ||
| p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome | Q35103179 | ||
| The 17q23 amplicon and breast cancer | Q35130683 | ||
| Novel patterns of genome rearrangement and their association with survival in breast cancer | Q35173695 | ||
| Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages | Q35206840 | ||
| Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents | Q35673760 | ||
| High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays | Q35747499 | ||
| Progesterone regulation of stem and progenitor cells in normal and malignant breast | Q35784828 | ||
| A refined molecular taxonomy of breast cancer | Q35838290 | ||
| Development of the human breast | Q35879657 | ||
| Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer | Q35901185 | ||
| Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio | Q35984061 | ||
| P433 | issue | 34 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 4429-4438 | |
| P577 | publication date | 2014-11-10 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Wip1 phosphatase in breast cancer | |
| P478 | volume | 34 |
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| Q58560690 | Integrative Proteomic and Phosphoproteomic Profiling of Testis from Wip1 Phosphatase-Knockout Mice: Insights into Mechanisms of Reduced Fertility |
| Q41550658 | MicroRNA16 regulates glioma cell proliferation, apoptosis and invasion by targeting Wip1-ATM-p53 feedback loop |
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| Q99414093 | Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma |
| Q41494240 | WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma |
| Q40063448 | Wip1 Deficiency Promotes Neutrophil Recruitment to the Infection Site and Improves Sepsis Outcome |
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| Q26863035 | Wip1 phosphatase: between p53 and MAPK kinases pathways |
| Q41455191 | Wip1-dependent modulation of macrophage migration and phagocytosis. |
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